Patents by Inventor John Lightholder

John Lightholder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR INHIBITING EXCESS NUCLEIC ACID PRECIPITATION
    Publication number: 20240011012
    Abstract: The present disclosure describes improved methods for use in purifying biological products made by host cells. In some embodiments, the improved methods comprise one or more steps of lysing host cells, such as with a detergent, to release the biological product, precipitating host cell DNA, such as with domiphen bromide, and then inhibiting precipitation of residual host cell DNA in a supernatant containing the biological product by adding a salt to a sufficient final concentration. In some embodiments, the biological product is a vaccine, or a viral vector for gene therapy, such as an AAV vector or a lentiviral vector.
    Type: Application
    Filed: December 17, 2021
    Publication date: January 11, 2024
    Inventors: Neha KALLA, William KISH, John LIGHTHOLDER, Zhuo LIU, Eric VORST, Tamara ZEKOVIC
  • Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same
    Patent number: 8859252
    Abstract: The present invention relates generally to prostatic acid phosphatase (PAP), compositions comprising the same, and methods for producing and/or purifying the same.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: October 14, 2014
    Assignee: Aerial BioPharma, LLC
    Inventors: Jonathan Mitschelen, John Lightholder, Gary Bream, Kenneth Freeman