Patents by Inventor John Lindenbaum

John Lindenbaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5457055
    Abstract: A method of diagnosing cobalamin deficiency in warm-blooded animals is described. In one embodiment, this method comprises the measurement of methylmalonic acid levels in cerebral spinal fluid to determine if such levels exceed normal range. A finding of elevated levels indicates a cobalamin deficiency. In another embodiment, the method comprises the measurement of methylmalonic acid levels in cerebral spinal fluid and serum. A finding that the ratio of methylmalonic acid in cerebral spinal fluid to that in serum is above normal is indicative of a cobalamin deficiency. Additionally, a method for assessing the effectiveness of cobalamin therapy is described. The effectiveness of therapy is assessed by determining whether cerebral spinal fluid levels of methylmalonic acid have returned to normal, or by determining whether the ratio of methylmalonic acid in cerebral spinal fluid to that in serum has returned to normal range.
    Type: Grant
    Filed: September 4, 1992
    Date of Patent: October 10, 1995
    Assignee: The University of Colorado Foundation
    Inventors: Robert H. Allen, Sally P. Stabler, John Lindenbaum
  • Patent number: 5374560
    Abstract: A method for screening and distinguishing between cobalamin deficiency and folic acid deficiency by relating elevated levels of cystathionine to cobalamin or folic acid deficiency and relating elevated levels of 2-methylcitric acid to cobalamin deficiency but not folic acid deficiency. The methods can be used alone or in combination with other methods for detecting and distinguishing between cobalamin deficiency and folic acid deficiency.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: December 20, 1994
    Assignee: The University of Colorado, Inc.
    Inventors: Robert H. Allen, Sally P. Stabler, John Lindenbaum
  • Patent number: 4940658
    Abstract: Method for determining levels of sulfhydryl amino acids, particularly total homocysteine levels in samples of body tissue from warm-blooded animals, methods of detecting cobalamin and folic acid deficiency using an assay for total homocysteine levels, and methods for distinguishing cobalamin from folic acid deficiency using an assay for total homocysteine levels in conjunction with an assay for methylmalonic acid.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: July 10, 1990
    Assignee: University Patents, Inc.
    Inventors: Robert H. Allen, Sally P. Stabler, John Lindenbaum