Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A golf club head is described having a body defining an interior cavity and comprising a heel portion, a toe portion, and a sole portion positioned at a bottom portion of the golf club head, and a crown positioned at a top portion. The body has a forward portion and a rearward portion. The club head can have a non-metallic striking surface positioned at the forward portion of the body.

Abstract: A golf club head includes a club body including a crown, a sole, a skirt disposed between and connecting the crown and the sole and a face portion connected to a front end of the club body. The face portion includes a geometric center defining the origin of a coordinate system when the golf club head is ideally positioned, the coordinate system including an x-axis being tangent to the face portion at the origin and parallel to a ground plane, a y-axis intersecting the origin being parallel to the ground plane and orthogonal to the x-axis, and a z-axis intersecting the origin being orthogonal to both the x-axis and the y-axis. The golf club head defines a center of gravity CG, the CG being a distance CGY from the origin as measured along the y-axis and a distance CGZ from the origin as measured along the z-axis.

Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Participation by multiple users in an online game through client computing platforms associated with the users is facilitated. User accounts associated with the users indicate affiliations having a functional significance between users. Presentation of offers to sell virtual items are provided to users having a first affiliation and to users having a second affiliation. The virtual items associated with the offers are distributed to the users having a first affiliation upon an indication that a threshold number of users having the first affiliation have accepted the offer and are not distributed to users having a second affiliation upon an indication that a threshold number of users having the second affiliation have not accepted the offer.

Abstract: This invention relates to thermoset, thermal insulating panel, pour-in-place and pour-in-place foams having desirable and unexpectedly low thermal conductivity, and to compositions, method and systems which use and/or are used to make such foams comprising: (a) providing thermosetting foam forming component and a blowing agent for forming predominantly closed cells in the foam, wherein the blowing agent comprises: (i) cis-1,1,1,4,4,4-hexafluoro-2-butene (HFO-1336mzzm(Z)) and cyclopentane, with the HFO-1336mzzm(Z) and cyclopentane in the blowing agent together comprising at least about 50% by weight of the total of all components in the blowing agent and (ii) the weight ratio of HFO-1336mzzm(Z) to cyclopentane in the blowing agent is from about 45:55 to less than 68:32 and (b) forming foam from said provided foamable composition.

Abstract: An orthopedic device delivers dynamic forces to a desired remote bone region. Dynamically arranged mechanical forces are known to stimulate bone cells (the process of mechanotransduction). The device includes an implantable element configured to couple with a generally accessible and healthy bone area, from which location it's configured to transmit forces to a remote bone area in need of repair, regrowth, or regeneration. Further, the device positions and orients the implantable element where it can be readily acted on by the device's force generator. The force generator is configured to impart dynamic forces that are transmitted through the implantable element and into a desired bone mass including a remote bone area in need of repair. This device promotes fracture healing, treats osteoporotic or other poor quality bone, and promotes vertebral fusion in conjunction with a spinal fusion procedure.

Abstract: An orthopedic device delivers dynamic forces to a desired remote bone region. Dynamically arranged mechanical forces are known to stimulate bone cells (the process of mechanotransduction). The device includes an implantable element configured to couple with a generally accessible and healthy bone area, from which location it's configured to transmit forces to a remote bone area in need of repair, regrowth, or regeneration. Further, the device positions and orients the implantable element where it can be readily acted on by the device's force generator. The force generator is configured to impart dynamic forces that are transmitted through the implantable element and into a desired bone mass including a remote bone area in need of repair. This device promotes fracture healing, treats osteoporotic or other poor quality bone, and promotes vertebral fusion in conjunction with a spinal fusion procedure.

Abstract: An operating table has first bed platforms, each which can rotate. In an operating configuration, the patient lies on one of the bed platforms in a prone or supine position with the bed platform centered over the base. When the patient needs to be turned, the other table extends outwardly, and both tables are rotated to position the patient for turning. Once the patient is turned, the table on which the patient lies is returned to its operating position over the base and the other table is returned to its storage position.

Abstract: An IO method and system for bit-deskewing are described. Embodiment includes a computer system with multiple components that transfer data among them. In one embodiment, a system component receives a forward strobe signal and multiple data bit signals from a transmitting component. The receiving component includes a forward strobe clock recovery circuit configurable to align a forward strobe sampling clock so as to improve sampling accuracy. The receiving component further includes at least one data bit clock recovery circuit configurable to align a data bit sampling clock so as to improve sampling accuracy, and to receive a signal from the forward strobe clock recovery circuit that causes the data bit sampling clock to track the forward strobe sampling clock during system operation.

Abstract: A request is received from a client for a web page hosted by a web server. Responsive to this request, a persistent client state object having an identifier therein is returned to the client. When a request is received from a client for elements of the web page hosted by the web server, the client is first required to return the persistent client state object having the identifier therein before the requested web page element is sent to the client.

Abstract: A processor such as a digital signal processor (DSP) is used to dynamically generate patterns and/or sequences of patterns for a spatial light modulator (SLM), such as a micromirror device, for the purpose of processing light. The combination of the processor and modulator has afforded optical signal processing in the digital domain and programmability that cannot be achieved with conventional analog optical computing.

Abstract: An operating table has first bed platforms, each which can rotate. In an operating configuration, the patient lies on one of the bed platforms in a prone or supine position with the bed platform centered over the base. When the patient needs to be turned, the other table extends outwardly, and both tables are rotated to position the patient for turning. Once the patient is turned, the table on which the patient lies is returned to its operating position over the base and the other table is returned to its storage position.

Abstract: An IO method and system for bit-deskewing are described. Embodiment includes a computer system with multiple components that transfer data among them. In one embodiment, a system component receives a forward strobe signal and multiple data bit signals from a transmitting component. The receiving component includes a forward strobe clock recovery circuit configurable to align a forward strobe sampling clock so as to improve sampling accuracy. The receiving component further includes at least one data bit clock recovery circuit configurable to align a data bit sampling clock so as to improve sampling accuracy, and to receive a signal from the forward strobe clock recovery circuit that causes the data bit sampling clock to track the forward strobe sampling clock during system operation.

Abstract: A turbine component such as a turbine blade has a cooling chamber that is tapered. The taper induces and maintains a helical swirl that improves the cooling efficiency of the cooling process and enables the turbine component to operate at higher temperatures.

Abstract: A method and apparatus are disclosed for identifying and cataloging software assets contained on a networked computer. In accordance with one embodiment, there is provided a method comprising providing a data warehouse including a master catalog file. The master catalog file comprises a software items table of attributes, a software packages table of attributes, and a mapping rules table for mapping certain software item entries to certain software package entries.

Abstract: Power transient control in an optical network by power measurement and prediction with a simple-to-compute model to drive an optical filter control.

Abstract: 9,11-Cycloendoperoxide derivatives of biologically active prostaglandin analogs, and particularly of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H2 1-ethanolamide or of structurally closely related analogs, are pro-drugs which hydrolyze under physiological conditions to provide prostaglandin analogues that are capable of providing sustained ocular and other in vivo concentrations of the respective drugs. The compounds of the invention have the formula shown below where the variables have the meaning defined in the specification.

Abstract: Adaptive dynamic optical filters with wavelength spreading onto a micromirror array and re-configurable attenuation according to measured intensity as a function of wavelength.