Abstract: Systems and methods are described for automated threat detection. For example, the system receives labels that are generated by an unsupervised machine learning model. Using the labels, the system initiates a training process of a supervised machine learning model using the set of labels from the unsupervised machine learning model. The supervised machine learning model can generate a set of clustered data during an inference process. The supervised machine learning model can be updated and stored in a model data store for future inference processes on new data.

Abstract: Systems and methods are described for automated threat detection. For example, the system receives various types of unlabeled data and determines, through an unsupervised machine learning model, a label for the data. The labels are provided to a supervised machine learning model during a first training process. When new data is received, the supervised machine learning model is executed during an inference process to cluster the new data in accordance with the labels that were determined by the unsupervised machine learning model. In some examples, a label audit process may be implemented to update the cluster/output of the supervised machine learning model. The updated labels from the label audit process may be provided back to the supervised machine learning model during a second training process. In other words, the system may combine the unsupervised machine learning model with a supervised machine learning model to perform automated threat detection.

Abstract: A chainsaw system includes a chainsaw and a saw blade module, which has a cutting chain and at least one guide unit for forming a guide for at least one part of the cutting chain. The chainsaw system further includes at least one coupling unit for coupling the saw blade module to the chainsaw and at least one release unit that has at least one fastening element and is provided in order to provide tool-free decoupling of the at least one saw blade module which is coupled by means of the coupling unit.

Abstract: A chainsaw system includes a chainsaw and a saw blade module, which has a cutting chain and at least one guide unit for forming a guide for at least one part of the cutting chain. The chainsaw system further includes at least one coupling unit for coupling the saw blade module to the chainsaw and at least one release unit that has at least one fastening element and is provided in order to provide tool-free decoupling of the at least one saw blade module which is coupled by means of the coupling unit.

Abstract: An oscillating gardening device includes a drive unit and at least one cam gear that is configured to be driven by the drive unit and has at least one guide section configured to guide at least one element. The guide section is rotatable about an axis of rotation and closed relative to the rotation axis in the circumferential direction. The guide section is arranged eccentrically with respect to the axis of rotation and deviates at least substantially from one or more of a circular shape and a circular ring shape in the circumferential direction. The oscillating gardening device in at least one embodiment is configured as one or more of hedge shears, grass shears, and branch shears.

Abstract: An oscillating gardening device includes a drive unit and at least one cam gear that is configured to be driven by the drive unit and has at least one guide section configured to guide at least one element. The guide section is rotatable about an axis of rotation and closed relative to the rotation axis in the circumferential direction. The guide section is arranged eccentrically with respect to the axis of rotation and deviates at least substantially from one or more of a circular shape and a circular ring shape in the circumferential direction. The oscillating gardening device in at least one embodiment is configured as one or more of hedge shears, grass shears, and branch shears.

Abstract: The present invention provides novel trimethylammonium compounds, of the Formula: (I) methods of making these compounds, methods of using the compounds for preparation of tau imaging agents, and preparation of tau imaging agent formulations.

Abstract: A line trimmer or mower head includes an automatic and/or manual line feed system with reduced tendency for cut and worn line to retract fully back into the spool housing. The line trimmer includes a rotatable spool assembly of at least one feedable line, at least one primary wall member adjacent a periphery of said spool assembly and a guide passage extending generally radially away from said primary wall member. The guide passage is partly defined by a substantially radially extending first formation arranged to bear upon line extending through said guide passage, such that in use line located within said guide passage is restricted to a substantially radial orientation.

Abstract: The synthesis of N-methyl-homocysteines and their use are described.

Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via (Tc-99m) binding moieties. In particular, the peptide reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.

Abstract: The synthesis of N-methyl-homocysteines and their use are described.

Abstract: This invention relates to calcitonin receptor binding reagents Comprising Compounds which are Covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding peptide derivatives and analogues of calcitonin which may be radiolabeled with a suitable isotope and used as radiodiagnostic or radiotherapeutic agents. Methods and kits for making, radiolabeling and using such reagents diagnostically and therapeutically in a mammalian body are also provided.

Abstract: This invention relates to calcitonin receptor binding reagents comprising compounds which are covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding peptide derivatives and analogues of calcitonin which may be radiolabeled with a suitable isotope and used as radiodiagnostic or radiotherapeutic agents. Methods and kits for making, radiolabeling and using such reagents diagnostically and therapeutically in a mammalian body are also provided.

Abstract: The invention provides novel peptide-based pharmacophores and compounds which bind somatostatin receptors with high affinity and which exhibit improved pharmacokinetic properties over known somatostatin analogs. The pharmacophores and compounds of the invention may be used in labeled or unlabeled form for diagnosing and/or treating somatostatin responsive diseases. The invention also provides radiopharmaceuticals and kits comprising these compounds, as well as methods for diagnosing and/or treating somatostatin receptor mediated diseases.

Abstract: A jig is disclosed and which includes a carrier; an elongate member having an end portion which is located relative to the carrier so that the elongate member is movable arcuately upward and downwardly on a first axis and is rotatable on a second axis extending at right angles to the first axis; an article engaging assembly located at an end portion of the elongated member remote from the first and second axis is provided, and is movable towards and away from the elongate member on a third axis extending transversely of the elongate member.

Abstract: This invention provides scintigraphic imaging agents and reagents for preparing said agents, methods for radiolabeling said reagents and kits containing non-radioactive reagents and other components for the convenient preparation of the scintigraphic imaging agents. More specifically, the invention provides scintigraphic imaging agents that are radiolabeled compounds which bind with high affinity to GPIIb/IIIa receptors on activated platelets and using such radiolabeled compounds derivatives to image sites in a mammalian body.

Abstract: This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (186Re) and rhenium-188 (188Re) for use as radiotherapeutic agents.

Abstract: The invention provides compounds comprising glycoprotein IIb/IIIa receptor-binding benzodiazepine derivatives covalently linked to metal ion chelators. The compounds of the invention may be labeled with a radionuclide such as 99mTc and used to image thrombi.

Abstract: This invention relates to antithrombotic agents and uses thereof. Specifically, the invention relates to chemical moieties that specifically bind to platelets and inhibit their aggregation, including linear and cyclic peptides. The invention provides methods for using these antithrombotic agents to prevent the formation of thrombi at sites in a mammalian body. In particular, the platelet-specific binding moieties including linear and cyclic peptides of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the platelet-specific binding moieties including linear and cyclic peptides. Effficacious antithrombotic agents are thereby provided.

Abstract: This invention relates to antithrombotic agents and uses thereof. Specifically, the invention relates to chemical moieties that specifically bind to platelets and inhibit their aggregation, including linear and cyclic peptides. The invention provides methods for using these antithrombotic agents to prevent the formation of thrombi at sites in a mammalian body. In particular, the platelet-specific binding moieties including linear and cyclic peptides of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the platelet-specific binding moieties including linear and cyclic peptides. Efficacious antithrombotic agents are thereby provided.