Patents by Inventor John Liu
John Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965810Abstract: An exemplary method and system is disclosed that facilitate the integration of multiplexed single-cell impedance cytometry in a high throughput format, which can be deployed upstream from microfluidic sample preparation and/or downstream to microfluidic cell separation. In exemplary method and system may employ impedance-based quantification of cell electrophysiology on the same microfluidic chip (i.e., “on-chip”) to provide distinguishing phenotypic information on the sample, without the need for additional sample handling, preparation or dilution steps as would be needed for other flow cytometry techniques.Type: GrantFiled: September 26, 2019Date of Patent: April 23, 2024Assignee: University of Virginia Patent FoundationInventors: Nathan Swami, John McGrath, Walter Varhue, Carlos Honrado, Vahid Farmehini, Yi Liu
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Publication number: 20240124442Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.Type: ApplicationFiled: February 3, 2022Publication date: April 18, 2024Applicant: AMGEN INC.Inventors: Albert AMEGADZIE, Diane Jennifer BEYLKIN, Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Kevin Lloyd GREENMAN, Todd J. KOHN, Kexue LI, Qingyian LIU, Ana Elena MINATTI, Primali Vasundera NAVARATNE, Liping H. PETTUS, Rene RAHIMOFF, Hui-Ling WANG, Nicholas Anthony WEIRES
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Patent number: 11958911Abstract: Disclosed are antibodies thereof that bind to coagulation factor XI (FXI) and/or its activated form factor XIa (FXIa), or to fragments of FXI and/or FXIa, and compositions containing the antibodies. Also disclosed are methods of preparing the antibodies and use of the antibodies for treating and/or preventing coagulation associated conditions such as thrombosis and complications or conditions associated with thrombosis.Type: GrantFiled: August 9, 2019Date of Patent: April 16, 2024Assignee: Shanghai Benemae PharmaceuticalInventors: Wenyi Wang, Quan Yu, Xiaowu Liu, John Liuzhong Xu, Zhiqiang Du
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Publication number: 20240119570Abstract: A method includes identifying, using at least one processing device of an electronic device, a spatially-variant point spread function associated with an under-display camera. The spatially-variant point spread function is based on an optical transmission model and a layout of a display associated with the under-display camera. The method also includes generating, using the at least one processing device, a ground truth image. The method further includes performing, using the at least one processing device, a convolution of the ground truth image based on the spatially-variant point spread function in order to generate a synthetic sensor image. The synthetic sensor image represents a simulated image captured by the under-display camera. In addition, the method includes providing, using the at least one processing device, the synthetic sensor image and the ground truth image as an image pair to train a machine learning model to perform under-display camera point spread function inversion.Type: ApplicationFiled: October 11, 2022Publication date: April 11, 2024Inventors: Yibo Xu, Weidi Liu, Hamid R. Sheikh, John Seokjun Lee
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Publication number: 20240115746Abstract: A device including a housing that is substantially impermeable to ultraviolet radiation having a wavelength of from 280 nm to 400 nm, and at least one window defined in the housing, the window including a UV-C radiation band-pass mirror film having a multiplicity of alternating first and second optical layers collectively transmitting UV-C radiation at a wavelength from at least 100 nm to less than 280 nm and not transmitting UV-A and UV-B radiation at a wavelength of from 280 nm to 400 nm, and an ultraviolet radiation source positioned within the housing, the ultraviolet radiation source being capable of emitting ultraviolet radiation at one or more wavelength from 100 nm to 400 nm. The device optionally further includes an ultraviolet mirror film positioned within the housing so as to reflect ultraviolet radiation emitted by the ultraviolet radiation source. A method of disinfecting a material is also disclosed.Type: ApplicationFiled: November 23, 2021Publication date: April 11, 2024Inventors: Timothy J. Hebrink, John A. Wheatley, Bharat R. Acharya, Tao Liu, Stephen P. Maki, Gilles J.B. Benoit, Sean M. Sweetnam
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Publication number: 20240121655Abstract: Methods, systems, and devices for wireless communication are described. For example, the described techniques provide for a first device (e.g., a cellular modem or user equipment (UE)) mapping quality of service flows of a first radio access technology (e.g., cellular) to service classes of a second RAT (e.g., Wi-Fi). The first device may communicate mapping information that indicates the mapping to a second network device (e.g., a router). The first device and the second device may communicate various packets via the quality of service flows and the service classes.Type: ApplicationFiled: October 5, 2022Publication date: April 11, 2024Inventors: Xiaolong Huang, Patrick Poon-Cheuk Chan, Sebastian Speicher, Huichun Liu, Suli Zhao, Sai Yiu Duncan Ho, John Thomas Harrsen
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Publication number: 20240119993Abstract: A memory controller monitors memory command selected for dispatch to the memory and sends commands controlling a read clock state. A memory includes a read clock circuit and a mode register. The read clock circuit has an output for providing a hybrid read clock signal in response to a clock signal and a read clock mode signal. The read clock circuit provides the hybrid read clock signal as a free-running clock signal that toggles continuously, and as a strobe signal that is active only in response to the memory receiving a read command.Type: ApplicationFiled: December 20, 2023Publication date: April 11, 2024Applicant: Advanced Micro Devices, Inc.Inventors: Aaron John Nygren, Kathik Gopalakrishnan, Tsun Ho Liu
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Patent number: 11952039Abstract: An electric-vehicle frame includes a mid-section and an end section. The mid-section has first and second frame rails spaced from each other by a first distance along a cross-vehicle axis defining a battery compartment therebetween. The end-section has first and second frame rails spaced from each other by a second distance along the cross-vehicle axis smaller than the first distance. A first connector is fixed to the first frame rail of the mid-section and to the first frame rail of the end-section. A second connector is fixed to the second frame rail of the mid-section and to the second frame rail of the end-section.Type: GrantFiled: August 3, 2023Date of Patent: April 9, 2024Assignee: Ford Global Technologies, LLCInventors: Ajay Kumar Gupta, Leonard Anthony Shaner, Yu Liu, John Wesley Stanley, Yu-Kan Hu, Fungtai Charles Ko, Petros Frantzeskakis
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Patent number: 11956629Abstract: Authenticating a mobile user device with a mobile network operator in advance of an MNO authentication request from the mobile user device can be done by a satellite network sending an authentication request to the MNO system, obtaining a set of authentication vectors related to the mobile user device, storing them into a proxy home location register, receiving the MNO authentication request from the mobile user device, generating an authentication request response based on the authentication vectors, sending the authentication request response to the mobile user device, receiving an authentication response including a received signed response, comparing the received signed response with the stored signed response, and if the received signed response and stored signed response match, deem that to be a successful authentication, add an MNO location update message to a request queue and forward the MNO location update message to the MNO system over the channel when available.Type: GrantFiled: October 5, 2021Date of Patent: April 9, 2024Assignee: Lynk Global, Inc.Inventors: Tyghe Robert Speidel, Clint Smith, John Meyer, Purnima Surampudi, James Liu
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Patent number: 11955921Abstract: One embodiment can provide a photovoltaic roof tile. The photovoltaic roof tile can include a transparent front cover, a transparent back cover, and a plurality of polycrystalline-Si-based photovoltaic structures positioned between the front cover and the back cover. A respective polycrystalline-Si-based photovoltaic structure has a front surface facing the front cover and a back surface facing the back cover. The photovoltaic roof tile can further include a paint layer positioned on a back surface of the back cover facing away from the front cover. A color of the paint layer substantially matches a color of the front surface of the respective polycrystalline-Si-based photovoltaic structure.Type: GrantFiled: June 15, 2022Date of Patent: April 9, 2024Assignee: Tesla, Inc.Inventors: John Liu, Yangsen Kang, Anh N. Duong, Yongkee Chae, Milan Padilla, Chen Wang, Remy D. Labesque
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Publication number: 20240108844Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.Type: ApplicationFiled: September 20, 2023Publication date: April 4, 2024Inventors: Hamish Adrian OSBORNE, Gavin Walsh Millar, Stephen David Evans, Bruce Gordon Holyoake, James William Stanton, David Leon McCauley, Gareth Thomas McDermott, Nicholas James Michael McKenna, Myfanwy Jane Antica Norton, Adrian John Elsworth, Michael John Andresen, Jonathan Andrew George Lambert, Sandeep Singh Gurm, Tessa Hazel Paris, Joseph Nathaniel Griffiths, Ping Si, Christopher Gareth Sims, Elmo Benson Stoks, Dexter Chi Lun Cheung, Peter Alan Seekup, Po-Yen Liu, Richard Edward Lang, Paul James Tonkin, Ian Lee Wai Kwan
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Publication number: 20240111402Abstract: Systems and processes for operating an intelligent automated assistant are provided. In one example, a plurality of data items selected by a user are received, wherein a plurality of confidence values corresponding to the plurality of data items are identified. The plurality of data items is ordered. The first data item is displayed, and updated context information associated with the electronic device is received. An update to the plurality of confidence values is detected, wherein the updated plurality of confidence values includes a third confidence value associated with a third data item of the plurality of ordered data items. In accordance with a determination that the third confidence value is higher than a first confidence value of the first data item, an order of the plurality of ordered data items is modified, and the third data item of the plurality of ordered data items is displayed.Type: ApplicationFiled: December 13, 2023Publication date: April 4, 2024Inventors: John L. BLATZ, Akshay AGGARWAL, Radhika BHARGAVA, Daiwei LIU, Pallavika RAMASWAMY, Kelvin Ting Pui SO
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Publication number: 20240108862Abstract: Systems and methods for a multi-layered peel-away sheath assembly for insertion of a blood pump, the peel-away sheath assembly including a sheath hub and a sheath body having a proximal end that is connected to the sheath hub, and a distal end. The sheath body comprises multiple layers including a reinforcing layer. The reinforcing layer improves flexibility and kink resistance of the assembly The reinforcing layer can comprise LCP, PEBAX, stainless steel, Nitinol, or Kevlar. The reinforcing layer may be a laser-cut hypotube or a braided or coiled filament. A first layer material and a third layer material are thermoplastics, including PEBAX or TPU. The reinforcing layer has at least one discontinuity, which is aligned with peel-away lines in the sheath body to allow an operator to peel-away the assembly. The peel-away lines are formed of inner notches, outer notches, or both. The sheath hub also includes a discontinuity to allow the sheath hub to peel-away.Type: ApplicationFiled: September 19, 2023Publication date: April 4, 2024Inventors: Christopher Nason Korkuch, Glen Fantuzzi, Drew Calabrese, Clifford Liu, John Modlish
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Patent number: 11945889Abstract: A bimodal ethylene-co-1-hexene copolymer consisting essentially of a higher molecular weight component and a lower molecular weight component and, when in melted form at 190 degrees Celsius, is characterized by a unique melt property space defined by a combination of high-load melt index, melt flow ratio, and melt elasticity properties. A blown film consisting essentially of the bimodal ethylene-co-1-hexene copolymer. A method of synthesizing the bimodal ethylene-co-1-hexene copolymer. A method of making the blown film. A manufactured article comprising the bimodal ethylene-co-1-hexene copolymer.Type: GrantFiled: June 7, 2019Date of Patent: April 2, 2024Assignee: Univation Technologies LLCInventors: Bo Liu, Joel D. Wieliczko, John F. Szul, Daudi A. Abe, Roger L. Kuhlman, Ayush A. Bafna, Timothy R. Lynn
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Publication number: 20240105525Abstract: Test structures and methods of testing pixel driver chip donor wafers are described. In an embodiment, a redistribution layer is formed over a pixel driver chip donor wafer and probed to determine known good dies, followed by removal of the RDL. In other embodiments, test routing is formed in the pixel driver chip using a polycide material or doped region in the semiconductor wafer.Type: ApplicationFiled: July 25, 2023Publication date: March 28, 2024Inventors: Imran Hashim, Xiang Lu, Stanley B. Wang, Xuchun Liu, Mahdi Farrokh Baroughi, Yongjie Jiang, Hopil Bae, Hasan Akyol, Baris Posat, John T. Wetherell, Lei Wu
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Publication number: 20240101658Abstract: Antibodies and antigen binding fragments thereof that immunospecifically bind OPN (OPN) and inhibit OPN activity are provided herein. The disclosed antibodies and antigen binding fragments are useful for modulating signal transduction through OPN proteins. The antibodies and antigen-binding fragments are useful for the treatment or prevention of cancer, osteoporosis, or other immune diseases.Type: ApplicationFiled: September 1, 2023Publication date: March 28, 2024Applicants: Augusta University Research Institute, Inc., The US Government as represented by the Department of Veterans AffairsInventors: Kebin Liu, John Klement, Priscilla S. Redd
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Publication number: 20240101570Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).Type: ApplicationFiled: November 22, 2021Publication date: March 28, 2024Inventors: Albert AMEGADZIE, Diane Jennifer BEYLKIN, Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Sanne Ormholt Schroder GLAD, Todd J. KOHN, Brian Alan LANMAN, Kexue LI, Qingyian LIU, Patricia LOPEZ, Francesco MANONI, Primali Vasundera NAVARATNE, Liping H. PETTUS, Rene RAHIMOFF, Nuria A. TAMAYO, Mikkel VESTERGAARD, Hui-Ling WANG, Nicholas Anthony WEIRES
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Publication number: 20240091953Abstract: A method for controlling a robotic system includes determining a location and/or a pose of a power system component based on data received from one or more sensors, and determining a mapping of a location of a robotic system within a model of an external environment of the robotic system based on the data. The model of the external environment provides locations of objects external to the robotic system. A sequence of movements of components of the robotic system is determined to perform maintenance on the power system component based on the locations of the objects external to the robotic system and/or the location or pose of the power system component. One or more control signals are communicated to remotely control movement of the components of the robotic system based on the sequence or movements of the components to perform maintenance on the power system component.Type: ApplicationFiled: November 30, 2023Publication date: March 21, 2024Inventors: Romano Patrick, Shiraj Sen, Arpit Jain, Huan Tan, Yonatan Gefen, Shuai Li, Shubao Liu, Pramod Sharma, Balajee Kannan, Viktor Holovashchenko, Douglas Forman, John Michael Lizzi, Charles Burton Theurer, Omar Al Assad, Ghulam Ali Baloch, Frederick Wilson Wheeler, Tai-Peng Tian
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Publication number: 20240083975Abstract: The present invention provides a chimeric molecule comprising a VWF protein fused to a heterologous moiety via a VWF linker. The invention provides an efficient VWF linker that can be cleaved in the presence of thrombin. The chimeric molecule can further comprise a polypeptide chain comprising a FVIII protein and a second heterologous moiety, wherein the chain comprising the VWF protein and the chain comprising the FVIII protein are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the chimeric proteins.Type: ApplicationFiled: July 25, 2023Publication date: March 14, 2024Inventors: Ekta Seth CHHABRA, John KULMAN, Tongyao LIU
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Publication number: 20240085404Abstract: The present disclosure relates to methods and compositions useful for measuring the transcytosis or recycling of a molecule. In particular, the present disclosure relates to in vitro receptor-dependent transcytosis or recycling assays for evaluating the clearance rates of therapeutic antibody molecules and Fc-fusion proteins in humans and animals.Type: ApplicationFiled: October 13, 2023Publication date: March 14, 2024Applicant: Genentech, Inc.Inventors: Chang LIU, John Hok Nin LOWE, Shan CHUNG