Patents by Inventor John Londesborough
John Londesborough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20090209016Abstract: A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and L-xylulose reductase, were identified. These genes, together with the known genes of the L-arabinose pathway, form a functional pathway. This pathway can be introduced to a fungus, which is completely or partially lacking this pathway.Type: ApplicationFiled: February 10, 2009Publication date: August 20, 2009Inventors: John Londesborough, Merja Penttila, Peter Richard
-
Patent number: 7527951Abstract: A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and L-xylulose reductase, were identified. These genes, together with the known genes of the L-arabinose pathway, form a functional pathway. This pathway can be introduced to a fungus, which is completely or partially lacking this pathway.Type: GrantFiled: February 15, 2002Date of Patent: May 5, 2009Assignee: Valtion Teknillinen TutkimuskeskusInventors: John Londesborough, Merja Penttilä, Peter Richard
-
Publication number: 20080038779Abstract: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.Type: ApplicationFiled: May 22, 2007Publication date: February 14, 2008Inventors: Andrei Miasnikov, Heikki Ojamo, Mira Povelainen, Hakan Gros, Mervi Toivari, Peter Richard, Laura Ruohonen, Kari Koivuranta, John Londesborough, Aristos Aristidou, Merja Penttila, Claire Plazanet-Menut, Josef Deutscher
-
Patent number: 7323326Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: GrantFiled: February 20, 2004Date of Patent: January 29, 2008Assignee: AB Enzymes OyInventors: Arja Miettinen-Oinonen, John Londesborough, Jari Vehmaanpera, Heli Haakana, Arja Mantyla, Raija Lantto, Minna Elovainio, Vesa Joutsjoki, Marja Paloheimo, Pirkko Suominen
-
Patent number: 7273748Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: GrantFiled: April 16, 2004Date of Patent: September 25, 2007Assignee: AB Enzymes OyInventors: Arja Miettinen-Oinonen, John Londesborough, Jari Vehmaanpera, Heli Haakana, Arja Mantyla, Raija Lantto, Minna Elovainio, Vesa Joutsjoki, Marja Paloheimo, Pirkko Suominen
-
Patent number: 7226761Abstract: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.Type: GrantFiled: July 20, 2001Date of Patent: June 5, 2007Assignee: Danisco Sweeteners OyInventors: Andrei Miasnikov, Heikki Ojamo, Mira Povelainen, Hakan Gros, Mervi Toivari, Peter Richard, Laura Ruohonen, Kari Koivuranta, John Londesborough, Aristos Aristidou, Merja Penttila, Claire Plazanet-Menut, Josef Deutscher
-
Patent number: 7091014Abstract: The present invention relates to genetic engineering of production microorganisms used in biotechnology to improve their properties so that they produce useful products more efficiently. The microorganisms express at least one enzyme that causes the functional coupling of the oxidation and reduction of substrates by two pyridine nucleotide-linked dehydrogenase reactions with different specificities for the NAD/NADH and NADP/NADPH coenzyme couples and so facilitates the transfer of electrons between the two coenzyme couples through the said substrates. In particular the invention relates to increasing the yields of products such as ethanol or amino acids from carbon and nitrogen sources such as biomass comprising hexoes, pentoses or their polymers.Type: GrantFiled: March 11, 1999Date of Patent: August 15, 2006Assignee: Valtion Teknillinen TutkimuskeskusInventors: Aristos Aristidou, John Londesborough, Merja Penttilä, Peter Richard, Laura Ruohonen, Hans Söderlund, Anita Teleman, Mervi Toivari
-
Publication number: 20050106734Abstract: The present invention relates to fungal microorganism having an increased ability to carry out biotechnological process(es). In particular, the invention relates to improving the regeneration of redox cofactors in biotechnological processes where useful products are produced from biomass containing pentoses. According to the invention, the microorganism is transformed with a DNA sequence encoding an NADP linked glyceraldehyde 3-phosphate dehydrogenase. The invention can be used to provide useful products for mankind from biological materials, including e.g. agricultural and forestry products, municipal waste. Examples of such useful products are ethanol, lactic acid, polyhydroxyalkanoates, amino acids, fats, vitamins, nucleotides and a wide variety of enzymes and pharmaceuticals.Type: ApplicationFiled: October 29, 2002Publication date: May 19, 2005Inventors: Peter Richard, John Londesborough, Merja Penttila, Ritva Verho
-
Publication number: 20040185498Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: ApplicationFiled: April 16, 2004Publication date: September 23, 2004Inventors: Arja Miettinen-Oinonen, John Londesborough, Jari Vehmaanpera, Heli Haakana, Arja Mantyla, Raija Lantto, Minna Elovainio, Vesa Joutsjoki, Marja Paloheimo, Pirkko Suominen
-
Publication number: 20040142444Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: ApplicationFiled: February 20, 2004Publication date: July 22, 2004Inventors: Arja Miettinen-Oinonen, John Londesborough, Jari Vehmaanpera, Heli Haakana, Arja Mantyla, Raija Lantto, Minna Elovainio, Vesa Joutsjoki, Marja Paloheimo, Pirkko Suominen
-
Patent number: 6723549Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: GrantFiled: April 30, 1997Date of Patent: April 20, 2004Assignee: AB Enzymes OyInventors: Arja Miettinen-Oinonen, John Londesborough, Jari Vehmaanperä, Heli Haakana, Arja Mäntylä, Raija Lanto, Minna Elovainio, Vesa Joutsjoki, Marja Paloheimo, Pirkko Suominen
-
Publication number: 20030186402Abstract: A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and L-xylulose reductase, were identified. These genes, together with the known genes of the L-arabinose pathway, form a functional pathway. This pathway can be introduced to a fungus, which is completely or partially lacking this pathway.Type: ApplicationFiled: March 10, 2003Publication date: October 2, 2003Inventors: John Londesborough, Merja Penttil, Peter Richard
-
Publication number: 20030068791Abstract: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.Type: ApplicationFiled: July 20, 2001Publication date: April 10, 2003Applicant: Xyrofin OyInventors: Andrei Miasnikov, Heikki Ojamo, Mira Povelainen, Hakan Gros, Mervi Toivari, Peter Richard, Laura Ruohonen, Kari Koivuranta, John Londesborough, Aristos Aristidou, Merja Penttila, Claire Plazanet-Menut, Josef Deutscher
-
Publication number: 20020168751Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: ApplicationFiled: April 30, 1997Publication date: November 14, 2002Inventors: ARJA MIETTINEN-OINONEN, JOHN LONDESBOROUGH, JARI VEHMAANPERA, HELI HAAKANA, ARJA MANTYLA, RAIJA LANTTO, MINNA ELOVAINIO, VESA JOUTSJOKI, MARJA PALOHEIMO, PIRKKO SUOMINEN
-
Patent number: 6323001Abstract: Two nucleotide sequences encoding two different polypeptides found in yeast trehalose synthase have been isolated and cloned. A third polypeptide has been isolated from the enzyme and characterized, and a method is provided to isolate and clone the nucleotide sequence encoding this polypeptide. The coding sequences can be inserted into suitable vectors and used to transform host cells. The transformed cells will produce increased amounts of trehalose compared to the untransformed wild types and have increased tolerance to a variety of stresses, in particular to decreased availability of water. The invention may be used to improve the stress tolerance of organisms, to increase the storage life of foodstuffs and to produce trehalose economically on an industrial scale in an organism (e.g. baker's yeast) that is a traditional and safe foodstuff.Type: GrantFiled: January 26, 1998Date of Patent: November 27, 2001Assignee: BTG International Ltd.Inventors: John Londesborough, Outi Tunnela, Tapio Palva, Kjell-Ove Holmström, Björn Welin, Abul Mandal
-
Patent number: 6184019Abstract: Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.Type: GrantFiled: June 10, 1999Date of Patent: February 6, 2001Assignee: Röhm Enzyme Finland OYInventors: Arja Miettinen-Oinonen, John Londesborough, Jari Vehmaanperä, Heli Haakana, Arja Mäntylä, Raija Lantto, Minna Elovainio, Vesa Joutsjoki, Marja Paloheimo, Pirkko Suominen
-
Patent number: 6130368Abstract: The present invention concerns transgenic plants producing trehalose and methods of increasing the trehalose content of plants. According to the invention, the plants of interest are transformed with the coding sequence of a gene for trehalose-6-phosphate synthase fused to a non-constitutive plant promoter, which allows for temporal, topological or stress-induced control over the expression of the gene. The invention can be used for protecting staple crop plants against drought, high salinity or temperature extremes and for improving the storage properties of harvested plants including green food stuffs, picked fruits and ornamental plants.Type: GrantFiled: March 18, 1997Date of Patent: October 10, 2000Assignee: BTG International LtdInventors: John Londesborough, Outi Tunnela, Kjell-Ove Holmstrom, Einar Mantyla, Bjorn Welin, Abul Mandal, Tapio E. Palva
-
Patent number: 5792921Abstract: Two nucleotide sequences encoding two different polypeptides found in yeast trehalose synthase have been isolated and cloned. A third polypeptide has been isolated from the enzyme and characterized, and a method is provided to isolate and clone the nucleotide sequence encoding this polypeptide. The coding sequences can be inserted into suitable vectors and used to transform host cells. The transformed cells will produce increased amounts of trehalose compared to the untransformed wild types and have increased tolerance to a variety of stresses, in particular to decreased availability of water. The invention may be used to improve the stress tolerance of organisms, to increase the storage life of foodstuffs and to produce trehalose economically on an industrial scale in an organism (e.g, baker's yeast) that is a traditional and safe foodstuff.Type: GrantFiled: August 15, 1994Date of Patent: August 11, 1998Inventors: John Londesborough, Outi Tunnela nee Vuorio, Tapio Palva, Kjell-Ove Holmstrom, Bjorn Welin, Abul Mandal
-
Patent number: 5422254Abstract: Two nucleotide sequences encoding two different polypeptides found in yeast trehalose synthase have been isolated and cloned. The coding sequences can be inserted into suitable vectors and used to transform host cells. The transformed cells will produce increased amounts of trehalose compared to the untransformed wild types and have increased tolerance to a variety of stresses, in particular to decreased availability of water. The invention may be used to improve the stress tolerance of organisms, to increase the storage life of foodstuffs and to produce trehalose economically on an industrial scale in an organism (e.g, baker's yeast) that is a traditional and safe foodstuff.Type: GrantFiled: February 28, 1992Date of Patent: June 6, 1995Assignee: Oy Alko AbInventors: John Londesborough, Outi Vuorio