Abstract: Systems and methods for generating models of potential medical treatment pathways are provided. In some embodiments, the systems and methods determine estimated costs of medical treatment responsive to user input of medical conditions. Some embodiments generate candidate treatment pathways from historic medical claim information. The candidate treatment pathways can be based on a channel of care and a medical condition. Further embodiments determine a probability associated with a treatment pathway and determine potential costs for the treatment pathway within a respective channel of care for a medical condition. In some examples, the system provides cost estimates within each channel and/or for each treatment pathway. In other examples, the system can also identify a likelihood associated with each treatment pathway, assign weights based on occurrence, and calculate the costs for treatment paths using the calculated weights and, for example, location of service.