Abstract: A computer-implemented method of targeting electronic messages to travelers, comprising performing processing associated with: utilizing geographic information comprising itinerary information, to determine where the travelers are currently and/or are projected to be during a given time period; creating a list of travelers which categorizes the geographic information and/or traveler information about the travelers on the list; electronically notifying a merchant with information related to the list and the current geographic information and/or current traveler information of the travelers on the list; receiving an electronic request from the merchant to transmit an electronic targeted message to some or all of the travelers on the list; and transmitting the electronic targeted message to some or all of the travelers on the list.

Abstract: A computer-implemented method of targeting electronic messages to travelers, comprising performing processing associated with: utilizing geographic information comprising itinerary information, to determine where the travelers are currently and/or are projected to be during a given time period; creating a list of travelers which categorizes the geographic information and/or traveler information about the travelers on the list; electronically notifying a merchant with information related to the list and the current geographic information and/or current traveler information of the travelers on the list; receiving an electronic request from the merchant to transmit an electronic targeted message to some or all of the travelers on the list; and transmitting the electronic targeted message to some or all of the travelers on the list.

Abstract: Small organic molecule chromophores containing a benzo[c][1,2,5]thiadiazole with an electron-withdrawing substituent W in the 5-position (5BTH), benzo[c][1,2,5]oxadiazole with an electron-withdrawing substituent W in the 5-position (5BO), 2H-benzo[d][1,2,3]triazole (5BTR) with an electron-withdrawing substituent W in the 5-position (5BTR), 5-fluorobenzo[c][1,2,5]thiadiazole (FBTH), 5-fluorobenzo[c][1,2,5]oxadiazole (FBO), or 5-fluoro-2H-benzo[d][1,2,3]triazole (FBTR) core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic small molecule solar cells and transistors.

Abstract: The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I).

Abstract: This invention relates to a continuous vacuum pan (also sometimes referred to as an evaporative crystallizer) for use in the sugar processing industry, and to a heat exchanger used inside the continuous vacuum pan. The invention also relaters to the heat exchanger as used in other applications in the sugar processing industry. The heat exchanger includes a massecuite flow path for conveying massecuite therethrough, and a heat transfer medium flow path for receiving a heat transfer medium to enable heat transfer to the massecuite flow path. The heat exchanger is characterized therein that a periphery thereof is surrounded by an insulated zone in order to prevent heat transfer from the heat transfer medium flow path to the environment.

Abstract: A computer-implemented system and method for targeting messages to a traveler, comprising processing information associated with: receiving a request from a device of the traveler for itinerary information; utilizing geographic information, comprising itinerary information, to determine where the traveler is currently and/or is projected to be during a given time period; categorizing the geographic information and traveler information about the traveler from a database of travel and expense activity into a category; matching the category for the geographical information and/or traveler information about the traveler against a category for available targeted messages to determine if there are any matches; and transmitting targeted messages that have a category that matches a category for the geographical information and/or traveler information to the device of the traveler; wherein traveler information from the database of travel and expense activity is utilized to help determine what products and/or services

Abstract: A computer-implemented method of targeting electronic messages to travelers, comprising performing processing associated with: utilizing geographic information comprising itinerary information, to determine where the travelers are currently and/or are projected to be during a given time period; creating a list of travelers which categorizes the geographic information and/or traveler information about the travelers on the list; electronically notifying a merchant with information related to the list and the current geographic information and/or current traveler information of the travelers on the list; receiving an electronic request from the merchant to transmit an electronic targeted message to some or all of the travelers on the list; and transmitting the electronic targeted message to some or all of the travelers on the list.

Abstract: A system is disclosed for reducing power drain of a component when the component is in a powered down state. The system comprises a power input configured to receive power, a power output to the component, monitor logic configured to monitor a level of power moving between the input and output, and control logic configured to control power transfer between the input and output. The control logic may be in communication with the monitor logic and configured to selectively restrict power flow between the input and output when the monitor logic senses that power flow between the input and output falls below a threshold level. A method comprises checking a power level between the input and output, and if the power level exceeds a threshold, then permitting substantially unrestricted power flow. If the power level is less than the threshold, then restricting the power level between the input and output.

Abstract: A computer-implemented method and system for ancillary travel vendor fee expense management comprising: receiving, by at least one expense management application, travel expense transaction data, said travel expense transaction data further comprising at least one expense transaction attribute; generating, by the at least one expense management application, at least one travel expense transaction record, wherein said at least one travel expense transaction record includes said expense transaction data, and storing said at least one expense transaction record in an expense transaction database; determining, by at least one ancillary fee module which analyzes the at least one expense transaction attribute, whether the at least one expense transaction corresponds to a travel event, a fee for an ancillary good or service offered by a travel vendor, or a fee for an ancillary good or service offered by a travel agency; presenting the at least one expense transaction record on a computerized user interface contained

Abstract: This invention relates to a continuous vacuum pan (also sometimes referred to as an evaporative crystallizer) for use in the sugar processing industry, and to a heat exchanger used inside the continuous vacuum pan. The invention also relaters to the heat exchanger as used in other applications in the sugar processing industry. The heat exchanger includes a massecuite flow path for conveying massecuite therethrough, and a heat transfer medium flow path for receiving a heat transfer medium to enable heat transfer to the massecuite flow path. The heat exchanger is characterized therein that a periphery thereof is surrounded by an insulated zone in order to prevent heat transfer from the heat transfer medium flow path to the environment.

Abstract: The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.

Abstract: This invention concerns the use of a compound of formula (I?) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; aminocarbonyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with C1-4alkyl substituted piperidinyl, mono- or di(C1-6alkyl)amino, aminocarbonyl, mono- or di(C1-6alkyl)aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhaloC1-4alkyl; cyano; amino; mono- or di(C1-6alkyl)aminocarbonyl; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; aminoS(?O)2—; mono- or di(C1-6alkyl)aminoS(?O)2; —C(?N—Rx)NRyRz; Q is optionally substituted C3-6cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, or Q is a radical of formula L is optionally substituted phenyl or

Abstract: The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X1— represents C1-4alkyl, in particular methyl; —X2— represents —C1-4alkyl- or —C1-4alkyl-NR7—, in particular propyl, -ethyl-NR7— or -propyl-NR7—; —Y— represents-NR2—C1-6alkyl-CO—NR4—, -Het1-C1-6alkyl-CO—NR5— or -Het2-CO—NR6— and wherein the —C1-6alkyl-linker of —NR2—C1-6alkyl-CO—NR4— or -Het1-C1-6alkyl-CO—NR5— is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; R1 represents hydrogen, chloro, fluoro or bromo; R2 represents —C1-4alkyl-, in particular ethyl or methyl; R7 represents hydrogen; R8 represents hydrogen; R4, R5 and R6 represent hydrogen; Het1 is selected from piperazinyl or piperidinyl, in particular -piperazinyl; Het2 selected from pyrrolidinyl or piperidinyl, in particular pyrrolidi

Abstract: A counter-torque wrench includes a tubular outer body having distal and proximal ends and an inner shaft disposed within the outer body. The inner shaft has a proximal end and a distal end and is axially displaceable relative to the outer body. The distal end of the inner shaft has a gripping end portion disposed proximate to the distal end of the outer body. The gripping end portion comprises a plurality of branches extending distally of the outer body. The branches are radially displaceable between a relatively open position, in which the branches are displaced radially outwardly from one another, and a relatively closed position, in which the branches are displaced radially inwardly toward one another. The distance between the branches is greater in the open position than in the closed position. A method of using the counter-torque wrench is also provided.

Abstract: This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents phenyl, pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R1 represents hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; C1-6alkyl substituted with formyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl or C1-6alkylcarbonyloxy; X represents a direct bond; —(CH2)n3— or —(CH2)n4—X1a—X1b—; R2 represents an optionally substituted cyclic system; provided that N,3-diphenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine is not included; their use, pharmaceutical compositions comprising them and processes for their preparation.

Abstract: A system is disclosed for reducing power drain of a component when the component is in a powered down state. The system comprises a power input configured to receive power, a power output to the component, monitor logic configured to monitor a level of power moving between the input and output, and control logic configured to control power transfer between the input and output. The control logic may be in communication with the monitor logic and configured to selectively restrict power flow between the input and output when the monitor logic senses that power flow between the input and output falls below a threshold level. A method comprises checking a power level between the input and output, and if the power level exceeds a threshold, then permitting substantially unrestricted power flow. If the power level is less than the threshold, then restricting the power level between the input and output.

Abstract: This invention concerns compounds of formula N-oxides, pharmaceutically acceptable addition salts, quaternary amines and stereochemically isomeric forms thereof, their use, pharmaceutical compositions comprising them, and processes for their preparation.

Abstract: A power management system for a combustion engine is disclosed. The power management system has a fuel injector, a sensor, and a controller in communication with the sensor and the fuel injector. The fuel injector is operable to inject multiple shots of fuel into the combustion engine during a single injection event. The sensor is configured to sense a speed of the combustion engine and generate a signal indicative of the sensed speed. The controller is configured to limit the number of shots per injection event in response to the signal.

Abstract: This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21—C1-6alkyl; R21—O—; R21—S—; R21—C(?O)—; R21—S(?O)p—; R7—S(?O)p—; R7—S(?O)p—NH—; R21—S(?O)p—NH—; R7—C(?O)—; —NHC(?O)H; —C

Abstract: This invention concerns compounds of formula N-oxides, pharmaceutically acceptable addition salts, quaternary amines and stereochemically isomeric forms thereof, their use, pharmaceutical compositions comprising them, processes for their preparation, and methods of their use.