Abstract: Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents.

Abstract: Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents.

Abstract: Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p-B(OH)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the boronate group is protected.

Abstract: Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p -B(OH)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the boronate group is protected. Methods for treating AIDS and ARC as well as providing a method for treating or preventing HIV infection.

Abstract: Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p-B(OH)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the boronate group is protected.

Abstract: Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents.

Abstract: Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins.

Abstract: An observation lock detector block receives I&Q correlations and generates error measurement vectors, each including phase, frequency, code, pseudorange, and covariance residual estimates, and generates validity indicator and confidence indicator vectors, one of which error measurement vectors is an output as a selected error measurement vector with a respective validity indicator and confidence indicator vector, both of which selected vectors are communicated to a navigation solution processor in a ultratightly coupled navigation system for providing improved estimations of a navigation solution, the indicators indicating the usefulness of measurement errors, the prefilter detector block comprising discriminators, sequential filters, observation lock detectors and a measurement selector for selecting measurement vector based on phase, frequency, and code discriminations, the measurement errors being residual estimates that are indicated as valid or invalid for dynamic propagation of the residuals in a na

Abstract: An observation lock detector receives I and Q correlations and measurement residuals and transforms the I and Q quadrature correlation outputs based upon computed code phase and carrier phase into transformed I and Q quadrature signals communicated to conventional output lock detectors to provide validity and confidence indicator signals for indicating that the residual estimates are valid for dynamic propagation of the residuals in a navigation receiver for improved performance especially in low signal-to-noise environments such as for use in an ultratight GPS navigation system.

Abstract: An observation lock detector block receives I&Q correlations and generates error measurement vectors, each including phase, frequency, code, pseudorange, and covariance residual estimates, and generates validity indicator and confidence indicator vectors, one of which error measurement vectors is an output as a selected error measurement vector with a respective validity indicator and confidence indicator vector, both of which selected vectors are communicated to a navigation solution processor in a ultratightly coupled navigation system for providing improved estimations of a navigation solution, the indicators indicating the usefulness of measurement errors, the prefilter detector block comprising discriminators, sequential filters, observation lock detectors and a measurement selector for selecting measurement vector based on phase, frequency, and code discriminations, the measurement errors being residual estimates that are indicated as valid or invalid for dynamic propagation of the residuals in a na

Abstract: An observation lock detector receives I and Q correlations and measurement residuals and transforms the I and Q quadrature correlation outputs based upon computed code phase and carrier phase into transformed I and Q quadrature signals communicated to conventional output lock detectors to provide validity and confidence indicator signals for indicating that the residual estimates are valid for dynamic propagation of the residuals in a navigation receiver for improved performance especially in low signal-to-noise environments such as for use in an ultratight GPS navigation system.