Abstract: A microphone assembly including an outer housing, an inner housing, a printed circuit board (PCB) and a cord. The outer housing includes an outer surface, an inner surface opposite the outer surface and defining an opening there through, and a plurality of attachment structures protruding from the inner surface thereof. The inner housing includes an outer surface, an opening, and a plurality of attachment structures protruding from the outer surface thereof. The PCB includes at least one micro-electromechanical systems (MEMS) microphone including an acoustic port. The PCB is coupled to the inner housing such that the acoustic port of the at least one MEMS microphone is positioned within the opening. The cord interconnects the attachment structures of the outer and inner housings, respectively, together.

Abstract: The disclosure provides a nozzle adapted for placement within a flowpath of a turbomachine. The nozzle includes an airfoil having a suction side; a pressure side opposing the suction side; a leading edge between the pressure side and the suction side; a trailing edge opposing the leading edge and between the pressure side and the suction side; a root region at a first radial end; a tip region at a second radial end opposite the first radial end; and a midspan region between the root region and the tip region. An endwall is connected with the root region or the tip region of the airfoil along the suction side, the pressure side, the trailing edge, and the leading edge. The trailing edge of the airfoil has an elliptical shape having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in TABLE I.

Abstract: The present invention relates to highly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian, peritoneal, or fallopian tube cancer. In particular, the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g., an immunoconjugate) in combination with a chemotherapeutic agent (in particular a gemcitabine compound, a topotecan compound, and a doxorubicin compound), improves the therapeutic index in the treatment of ovarian, peritoneal, or fallopian tube cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention, combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus an additional chemotherapeutic agent have a synergistic effect in the ovarian cancer therapeutic index.

Abstract: The present invention relates to surprisingly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian cancer. In particular, the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g.,, an immunoconjugate) in combination with at least two chemotherapeutic agents (in particular a taxane compound and a platinum compound), improves the therapeutic index in the treatment of ovarian cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention, combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus additional chemotherapeutic agents have a synergistic effect in the ovarian cancer therapeutic index.

Abstract: A heat exchanger (10) is provided with a PTO section (12) passing through its core (14), with all of the components of the heat exchanger (10) being brazed together at the same time during assembly of the heat exchanger (10).

Abstract: This invention relates to drug delivery and specifically to the preparation and use of functionalized carriers such as nanopolymers and nanovesicles for improved delivery of nucleic acid agents (NAA) to tissues and cells. These compounds have broad applicability for treating numerous diseases and disorders, including neurodegenerative and neuromuscular disorders. The concept encompasses preferably polymeric carriers for delivery of a class of oligonucleotides that modulate RNA splicing.

Abstract: A heat exchanger (10) is provided with a PTO section (12) passing through its core (14), with all of the components of the heat exchanger (10) being brazed together at the same time during assembly of the heat exchanger (10).

Abstract: According to one embodiment of the invention, a gas generator system includes a combustion chamber having an insulation coupled to an inside surface thereof, a retort having a catalyst therein disposed within the combustion chamber, and an access door coupled to a side of the combustion chamber. The access door allows removal of the retort from the side of the combustion chamber. According to another embodiment of the invention, a gas generator system includes a combustion chamber having an insulation coupled to an inside surface thereof, a retort having a catalyst therein disposed within the combustion chamber, and a recuperator disposed proximate an open bottom of the combustion chamber. The recuperator prevents secondary combustion air from traveling in a direct path into the combustion chamber from outside the open bottom of the combustion chamber and raises the temperature of the secondary combustion air.