Patents by Inventor John Lyle

John Lyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11111649
    Abstract: A working machine having a base assembly including a ground engaging structure; an undercarriage connected to the ground engaging structure; a superstructure connected to the undercarriage; a working arm mounted to the superstructure; a connector connecting the undercarriage to the superstructure; and a drive arrangement located in the base assembly for moving the ground engaging structure to propel, in use, the working machine.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: September 7, 2021
    Assignee: J. C. Bamford Excavators Limited
    Inventors: Jonathan Lyle, Peter Jowett, John Griffin, David Price, Nicholas Roberts, Ryan Page, Ian Carswell
  • Publication number: 20210147465
    Abstract: Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.
    Type: Application
    Filed: August 28, 2020
    Publication date: May 20, 2021
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Lubomir SEBO, Jeremiah HANES, Gene SHEN, Louis BROGLEY, Stephen YUE, Frank ZHENG, Yuri LAPIN, John LYLE, Honey OSUNA, Andrei FEDOROV
  • Publication number: 20210102181
    Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
    Type: Application
    Filed: July 14, 2020
    Publication date: April 8, 2021
    Inventors: David K. Hanzel, Geoff Otto, Paul S. Peluso, Thang Pham, David R. Rank, Fred Christians, Arekadiusz Bibillo, Insil Park, Sonya Clark, John Lyle
  • Publication number: 20210012654
    Abstract: One variation of a method for managing parking within a parking structure includes: after detecting a license plate number on a vehicle in an image captured by an entry camera unit arranged near an entry of the parking structure, labeling the license plate as unverified in a data log associated with the parking structure; in response to absence of validation of the license plate within a grace period after entry of the vehicle, relabeling the license plate as in-violation in the data log; in response to detecting the license plate in an image captured by a mobile enforcement unit moving through the parking structure, querying the data log for a status of the license plate; and, in response to the license plate labeled as in-violation in the data log, serving a prompt to an enforcement personnel to issue a citation to a vehicle carrying the license plate.
    Type: Application
    Filed: June 12, 2020
    Publication date: January 14, 2021
    Inventors: John Lyles, Fred Moore
  • Publication number: 20200377940
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: April 14, 2020
    Publication date: December 3, 2020
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue XU, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron L. Cicero
  • Publication number: 20200334593
    Abstract: The different advantageous embodiments further provide a system for hierarchical mission management comprising a number of mission planners, a data processing system, and a communication system. The number of mission planners are associated with a number of agent groups. The data processing system is configured to execute the number of mission planners. The communication system is configured to provide communication between the number of mission planners.
    Type: Application
    Filed: June 17, 2020
    Publication date: October 22, 2020
    Applicant: THE BOEING COMPANY
    Inventors: Emad William Saad, John Lyle Vian, Ryan James Meuth, Donald C. Wunsch, II
  • Patent number: 10810519
    Abstract: The different advantageous embodiments further provide a system for hierarchical mission management comprising a number of mission planners, a data processing system, and a communication system. The number of mission planners are associated with a number of agent groups. The data processing system is configured to execute the number of mission planners. The communication system is configured to provide communication between the number of mission planners.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: October 20, 2020
    Assignee: THE BOEING COMPANY
    Inventors: Emad William Saad, John Lyle Vian, Ryan James Meuth, Donald C. Wunsch, II
  • Patent number: 10800805
    Abstract: Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: October 13, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lubomir Sebo, Jeremiah Hanes, Gene Shen, Louis Brogley, Stephen Yue, Frank Zheng, Yuri Lapin, John Lyle, Honey Osuna, Andrei Fedorov
  • Patent number: 10787573
    Abstract: Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: September 29, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Frank Zheng, Jeremiah Hanes, Gene Shen, Louis Brogley, Stephen Yue, Yuri Lapin, John Lyle, Honey Osuna, Andrei Fedorov, Lubomir Sebo
  • Patent number: 10726718
    Abstract: One variation of a method for managing parking within a parking structure includes: after detecting a license plate number on a vehicle in an image captured by an entry camera unit arranged near an entry of the parking structure, labeling the license plate as unverified in a data log associated with the parking structure; in response to absence of validation of the license plate within a grace period after entry of the vehicle, relabeling the license plate as in-violation in the data log; in response to detecting the license plate in an image captured by a mobile enforcement unit moving through the parking structure, querying the data log for a status of the license plate; and, in response to the license plate labeled as in-violation in the data log, serving a prompt to an enforcement personnel to issue a citation to a vehicle carrying the license plate.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: July 28, 2020
    Assignee: Auto Park Hawaii, Inc.
    Inventors: John Lyles, Fred Moore
  • Patent number: 10717968
    Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: July 21, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Paul S. Peluso, David K. Hanzel, Geoff Otto, Thang Pham, Fred Christians, Arekadiusz Bibillo, Insil Park, Sonya Clark, John Lyle
  • Publication number: 20200219390
    Abstract: One variation of a method for managing parking within a parking structure includes: after detecting a license plate number on a vehicle in an image captured by an entry camera unit arranged near an entry of the parking structure, labeling the license plate as unverified in a data log associated with the parking structure; in response to absence of validation of the license plate within a grace period after entry of the vehicle, relabeling the license plate as in-violation in the data log; in response to detecting the license plate in an image captured by a mobile enforcement unit moving through the parking structure, querying the data log for a status of the license plate; and, in response to the license plate labeled as in-violation in the data log, serving a prompt to an enforcement personnel to issue a citation to a vehicle carrying the license plate.
    Type: Application
    Filed: January 6, 2020
    Publication date: July 9, 2020
    Inventors: John Lyles, Fred Moore
  • Patent number: 10655172
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 19, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
  • Patent number: 10612087
    Abstract: Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having monovalent cations that control the median pulse width for incorporated nucleotides are disclosed. The levels of monovalent cations are used to control pulse width while allowing other sequencing parameters to remain within a desirable range.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: April 7, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Andrei Fedorov, John Lyle, Keith Bjornson, Jeremiah Hanes
  • Publication number: 20190309171
    Abstract: Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.
    Type: Application
    Filed: December 4, 2018
    Publication date: October 10, 2019
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Frank ZHENG, Jeremiah HANES, Gene SHEN, Louis BROGLEY, Stephen YUE, Yuri LAPIN, John LYLE, Honey OSUNA, Andrei FEDOROV, Lubomir SEBO
  • Patent number: 10385108
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: August 20, 2019
    Assignee: GENZYME CORPORATION
    Inventors: Michael A. Perricone, John Lyle Dzuris, Timothy E. Weeden, James E. Stefano, Clark Q. Pan, Andrea E. Edling
  • Publication number: 20190194741
    Abstract: Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having lithium that control the median pulse width for incorporated nucleotides are disclosed. The levels of lithium are used to control pulse width while allowing other sequencing parameters to remain within a desirable range.
    Type: Application
    Filed: December 12, 2018
    Publication date: June 27, 2019
    Inventors: Andrei Fedorov, John Lyle, Keith Bjornson, Jeremiah Hanes
  • Patent number: 10294523
    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: May 21, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Benjamin Flusberg, Jonas Korlach, Jeffrey Wegener, Tyson A. Clark, Igor Drasko Vilfan, Andrey Kislyuk, Stephen Turner, Jon Sorenson, Kevin Travers, Cheryl Heiner, Austin B. Tomaney, Patrick Marks, Jessica Lee, Lei Jia, Dale Webster, John Lyle, Jeremiah Hanes
  • Patent number: 10184148
    Abstract: Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having lithium that control the median pulse width for incorporated nucleotides are disclosed. The levels of lithium are used to control pulse width while allowing other sequencing parameters to remain within a desirable range.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: January 22, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Andrei Fedorov, John Lyle, Keith Bjornson, Jeremiah Hanes
  • Patent number: D835845
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 11, 2018
    Inventors: Donald Graves, John Lyles