Patents by Inventor John Lyle

John Lyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spacecraft development testbed system
    Patent number: 8977391
    Abstract: A method and apparatus comprising a location reference system and a control module. The location reference system is configured to generate location information for a number of mobile platforms in an environment. The control module is configured to receive the location information for the number of mobile platforms from the location reference system. The control module is further configured to generate command signals for the number of mobile platforms using the location information. The control module is further configured to send the command signals to the number of mobile platforms to operate the number of mobile platforms in the environment such that operation of the number of mobile platforms emulates the operation of a number of spacecraft systems in a non-Earth terrestrial environment.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: March 10, 2015
    Assignee: The Boeing Company
    Inventors: Matthew Aaron Vavrina, John Lyle Vian
  • Articles having localized molecules disposed thereon and methods of producing same
    Patent number: 8975216
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: March 10, 2015
    Assignee: Pacific BioSciences of California
    Inventors: David Rank, Jonas Korlach, Yue Xu, Stephen Turner, Jeffrey Wegener, Daniel Roitman, John Lyle
  • Method of manufacturing a sensor network incorporating stretchable silicon
    Patent number: 8966730
    Abstract: A method of manufacturing a sensor network is described which includes stretching a silicon substrate over a desired area, and generating a plurality of nodes fabricated on the stretchable silicon substrate. The nodes include at least one of an energy harvesting and storage element, a communication device, a sensing device, and a processor. The nodes are interconnected via interconnecting conductors formed in the substrate.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: March 3, 2015
    Assignee: The Boeing Company
    Inventors: Michael Alexander Carralero, John Lyle Vian
  • PROTECTED FLUORESCENT REAGENT COMPOUNDS
    Publication number: 20150050659
    Abstract: Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.
    Type: Application
    Filed: August 5, 2014
    Publication date: February 19, 2015
    Inventors: Lubomir SEBO, Jeremiah HANES, Gene SHEN, Louis BROGLEY, Stephen YUE, Frank ZHENG, Yuri LAPIN, John LYLE, Honey OSUNA, Andrei FEDOROV
  • Methods and compositions for performing analytical operations
    Patent number: 8956816
    Abstract: Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: February 17, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Andrei Fedorov, Stephen Yue, Lei Sun, Gene Shen, John Lyle
  • Polymerases for nucleotide analogue incorporation
    Patent number: 8921086
    Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: December 30, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David K. Hanzel, Geoff Otto, Paul Peluso, Thang Pham, David R. Rank, Paul Mitsis, Fred Christians, Arek Bibillo, Insil Park, Sonya Clark, John Lyle
  • Sequencing methods using enzyme conformation
    Patent number: 8911972
    Abstract: Systems and methods are provided for single-molecule sequencing of template nucleic acids in which the signal from a label attached to a polymerase enzyme is used to monitor conformational changes in the polymerase which occur while labeled nucleotides or nucleotide analogs are added to a growing nucleic acid chain which is complementary to the template nucleic acid. The signal indicative of the conformational state of the enzyme is used to determine with higher confidence when true nucleotide or nucleotide analog incorporation events occur, allowing for the improved quality of base calls and sequence determination.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: December 16, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Mark Chaisson, Sonya Clark, Christopher Silk, John Lyle, Lei Jia, Keith Bjornson
  • Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same
    Publication number: 20140315756
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 23, 2014
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
  • Photodamage mitigation compounds and systems
    Patent number: 8834847
    Abstract: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: September 16, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Yue, Robert Weber, Xiangxu Kong, Andrei Fedorov, John Lyle
  • Autonomous inspection and maintenance
    Patent number: 8812154
    Abstract: The different advantageous embodiments may provide an apparatus that may comprise a number of mobile robotic machines, a wireless communications system and a computer system. The number of mobile robotic machines may be capable of moving to a number of locations in a maintenance area and may be capable of performing a number of maintenance operations on a structure in the maintenance area. The wireless communications system may be capable of providing communication with the number of mobile robotic machines within the maintenance area. The computer system may be capable of exchanging information with the number of mobile robotic machines using the wireless communications system.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: August 19, 2014
    Assignee: The Boeing Company
    Inventors: John Lyle Vian, Emad William Saad, Gregory J. Clark, Robert Daniel Kalinowski
  • Articles having localized molecules disposed thereon and methods of producing same
    Patent number: 8802600
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: August 12, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron Cicero
  • Methods and systems for analysis of fluorescent reactions with modulated excitation
    Patent number: 8802424
    Abstract: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: August 12, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Khai Luong, Paul Lundquist, Ravi Dalal, John Lyle, Stephen Turner
  • Articles having localized molecules disposed thereon and methods of producing same
    Patent number: 8772202
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 8, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
  • Electric head shaver
    Patent number: 8726528
    Abstract: An electric shaver includes a housing and a cutter head extending down from the housing. The housing contains the motor and is shaped to provide a grip that includes a pair of concave surfaces on the sides. An additional pair of concave surfaces is formed in the undersurface of the housing that accommodates the backs of the user's fingers when the cutter head is held for shaving.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: May 20, 2014
    Assignee: Skull Shaver, LLC
    Inventor: John Lyles
  • Forestry Management System
    Publication number: 20140081479
    Abstract: A method and apparatus of managing a forest. A forestry management system comprises a forestry manager. The forestry manager is configured to receive information about a forest from a group of autonomous vehicles, analyze the information to generate a result about a state of the forest from the information, and coordinate operation of the group of autonomous vehicles using the result.
    Type: Application
    Filed: September 19, 2012
    Publication date: March 20, 2014
    Applicant: The Boeing Company
    Inventors: John Lyle Vian, George Michael Roe, Josha Przbylko
  • Traffic and security monitoring system and method
    Patent number: 8643719
    Abstract: A method for monitoring a geographic area that using a plurality of unmanned mobile vehicles. Each unmanned mobile vehicle may be programmed with an operational plan to cover a specific subregion of said geographic area. Each unmanned mobile vehicle may be used to obtain visual images of its associated said subregion during operation. A surveillance system is also disclosed for monitoring a geographic area. The system includes a plurality of autonomously operated unmanned mobile vehicles. Each vehicle includes an onboard system that executes an operational plan to enable the vehicle to traverse a specific subregion of the geographic area. Each onboard system further includes a monitoring system to obtain visual images of its associated subregion.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: February 4, 2014
    Assignee: The Boeing Company
    Inventors: John Lyle Vian, Ali Reza Mansouri, Emad William Saad
  • Methods and Compositions for Performing Analytical Operations
    Publication number: 20140017674
    Abstract: Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.
    Type: Application
    Filed: June 4, 2013
    Publication date: January 16, 2014
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Andrei FEDOROV, Stephen Yue, Lei Sun, Gene Shen, John Lyle
  • CLASSIFICATION OF NUCLEIC ACID TEMPLATES
    Publication number: 20130316916
    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
    Type: Application
    Filed: June 28, 2013
    Publication date: November 28, 2013
    Inventors: Benjamin Flusberg, Stephen Turner, Jessica Lee, Lei Jia, Jonas Korlach, Jon Sorenson, Dale Webster, John Lyle, Kevin Travers, Jeremiah Hanes, Joseph Puglisi
  • PEPTIDE ANALOGS OF ALPHA-MELANOCYTE STIMULATING HORMONE
    Publication number: 20130303452
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Application
    Filed: May 8, 2013
    Publication date: November 14, 2013
    Inventors: Michael A. PERRICONE, John Lyle DZURIS, Timothy E. WEEDEN, James E. STEFANO, Clark Q. PAN, Andrea E. EDLING
  • Contoured electric head shaver
    Patent number: D693060
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: November 5, 2013
    Assignee: Skull Shaver, LLC
    Inventor: John Lyles