Abstract: An improvement in a nuclear fuel rod is disclosed. The improved fuel rod includes a cladding tube, a plurality of fuel pellets stacked within the cladding tube, and a liquid material filling the gap between the fuel pellets and the cladding tube. The liquid material is selected from those having a thermal conductivity higher than that of helium, a melting point lower than about 400° C., a boiling point higher than 1600° C., and which are capable of wetting both the fuel pellets and the cladding sufficient to form a protective layer over the pellets and to wick into openings that may form in the cladding.

Abstract: Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients.

Abstract: An improvement in a nuclear fuel rod is disclosed. The improved fuel rod includes a cladding tube, a plurality of fuel pellets stacked within the cladding tube, and a liquid material filling the gap between the fuel pellets and the cladding tube. The liquid material is selected from those having a thermal conductivity higher than that of helium, a melting point lower than about 400° C., a boiling point higher than 1600° C., and which are capable of wetting both the fuel pellets and the cladding sufficient to form a protective layer over the pellets and to wick into openings that may form in the cladding.

Abstract: Devices, systems, and methods for use in managing patient treatments utilizing pharmaceutical or therapeutic compounds. Methods include accessing one or more fields of information relating to any of a patient, physician and drug treatment and relating the one or more fields, or combination thereof, to a particular attribute or outcome. By analyzing the one or more fields of data in relation to the attribute or outcome, the system determines suitability of an intervention(s) and tasks the intervention(s) to one or more entities to facilitate the desired attribute or outcome. In certain aspects, the system facilitates identification of complex relationships and trends between seemingly unrelated fields of information and outputs information for use in an intervention or various other purposes according to the attribute or outcome desired by the user.

Abstract: Devices, systems, and methods for use in managing patient treatments utilizing pharmaceutical or therapeutic compounds. Methods include accessing one or more fields of information relating to any of a patient, physician and drug treatment and relating the one or more fields, or combination thereof, to a particular attribute or outcome. By analyzing the one or more fields of data in relation to the attribute or outcome, the system determines suitability of an intervention(s) and tasks the intervention(s) to one or more entities to facilitate the desired attribute or outcome. In certain aspects, the system facilitates identification of complex relationships and trends between seemingly unrelated fields of information and outputs information for use in an intervention or various other purposes according to the attribute or outcome desired by the user.

Abstract: Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients.

Abstract: An apparatus for controlling a turbogenerator system when a power electronics circuit of the turbogenerator system is unable to provide a sufficient load on the turbogenerator to prevent the turbogenerator from accelerating uncontrollably is described. The apparatus comprises a monitor including a first sensing device operable to detect a condition of the turbogenerator, and a brake controller responsive to a turbogenerator detection output from the first sensing device to issue a first brake control signal for operating a brake circuit to prevent the turbogenerator from accelerating uncontrollably and a second brake control signal for operating the brake circuit to permit resumption of normal operation of the turbogenerator.

Abstract: Devices, systems, and methods for use in managing patient treatments utilizing pharmaceutical or therapeutic compounds. Methods include accessing one or more fields of information relating to any of a patient, physician and drug treatment and relating the one or more fields, or combination thereof, to a particular attribute or outcome. By analyzing the one or more fields of data in relation to the attribute or outcome, the system determines suitability of an intervention(s) and tasks the intervention(s) to one or more entities to facilitate the desired attribute or outcome. In certain aspects, the system facilitates identification of complex relationships and trends between seemingly unrelated fields of information and outputs information for use in an intervention or various other purposes according to the attribute or outcome desired by the user.

Abstract: Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients.

Abstract: An apparatus for controlling a turbogenerator system when a power electronics circuit of the turbogenerator system is unable to provide a sufficient load on the turbogenerator to prevent the turbogenerator from accelerating uncontrollably is described. The apparatus comprises a monitor including a first sensing device operable to detect a condition of the turbogenerator, and a brake controller responsive to a turbogenerator detection output from the first sensing device to issue a first brake control signal for operating a brake circuit to prevent the turbogenerator from accelerating uncontrollably and a second brake control signal for operating the brake circuit to permit resumption of normal operation of the turbogenerator.

Abstract: An apparatus for controlling a turbogenerator system when a power electronics circuit of the turbogenerator system is unable to provide a sufficient load on the turbogenerator to prevent the turbogenerator from accelerating uncontrollably is described. The apparatus includes a monitor including a first sensing device operable to detect a condition of the turbogenerator, and a brake controller responsive to a turbogenerator detection output from the first sensing device to issue a first brake control signal for operating a brake circuit to prevent the turbogenerator from accelerating uncontrollably and a second brake control signal for operating the brake circuit to permit resumption of normal operation of the turbogenerator.

Abstract: An apparatus for controlling a turbogenerator system when a power electronics circuit of the turbogenerator system is unable to provide a sufficient load on the turbogenerator to prevent the turbogenerator from accelerating uncontrollably is described. The apparatus comprises a monitor including a first sensing device operable to detect a condition of the turbogenerator, and a brake controller responsive to a turbogenerator detection output from the first sensing device to issue a first brake control signal for operating a brake circuit to prevent the turbogenerator from accelerating uncontrollably and a second brake control signal for operating the brake circuit to permit resumption of normal operation of the turbogenerator.

Abstract: Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients.

Abstract: Devices, systems, and methods for use in managing patient treatments utilizing pharmaceutical or therapeutic compounds. Methods include accessing one or more fields of information relating to any of a patient, physician and drug treatment and relating the one or more fields, or combination thereof, to a particular attribute or outcome. By analyzing the one or more fields of data in relation to the attribute or outcome, the system determines suitability of an intervention(s) and tasks the intervention(s) to one or more entities to facilitate the desired attribute or outcome. In certain aspects, the system facilitates identification of complex relationships and trends between seemingly unrelated fields of information and outputs information for use in an intervention or various other purposes according to the attribute or outcome desired by the user.

Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

Abstract: A mixer according to the present disclosure may include a container for receiving material to be mixed, and a mixing assembly configured to extend into the container. The mixing assembly may include a rotatable shaft and multiple blade units connected to the shaft. Furthermore, each blade unit may include multiple parallel blades.

Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

Abstract: A method comprising forming a coating solution which comprises a matrix precursor material, a porogen material and a solvent, by selecting a polyarylene matrix precursor material which cross-links to form a matrix with a calculated cross-link moeity density of at least 0.003 moles/ml, and reacting the polyarylene matrix precursor material with a porogen which is linear oligomer or polymer which is formed from monomers comprising alkenyl or alkynyl functional monomers, which has reactive end groups and a weight average molecular weight in the range of less than about 5000, where the porogen is present in amounts in the range of about 10 to less than 50 percent by weight based on total weight of porogens and matrix precursor material.

Abstract: Compositions, kits and methods are provided for treating or preventing neurological disorders associated with aberrant silencing of gene expression by reestablishing the gene expression through inhibition of DNA methylation and/or histone deacetylase. The compositions and methods include administering to a patient suffering from the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor, such as decitabine, preferably in combination with an effective amount of a histone deacetylase inhibitor. The compositions, kits and methods can be used to treat or present neurological disorders such as Lou Gehrig's disease, fragile X syndrome, Parkinson's disease and Alzheimer's disease.