Patents by Inventor John M. Baust

John M. Baust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11026737
    Abstract: Embodiments of the present invention relate to cryogenic systems and methods useful to cool objects, including living tissue, to freezing or cryogenic temperatures by placing the object in thermal communication with sub-cooled supercritical nitrogen.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 8, 2021
    Assignee: Endocare, Inc.
    Inventors: John G. Baust, John M. Baust, Anthony T. Robilotto
  • Publication number: 20210128220
    Abstract: A cryoablation device is provide herein which, in an embodiment, includes a catheter shaft and a cryogen return line disposed within the catheter shaft. A cryogen supply line is disposed within the cryogen return line, such that the cryogen supply line, the cryogen return line, and the catheter shaft are all substantially coaxial. A needle tip probe is disposed at a distal end of the cryogen return line and the cryogen supply line extends in a distal direction beyond a distal end of the cryogen return line and into the needle tip probe. An insulating tube is disposed circumferentially around the cryogen return line and within the catheter shaft. An insulating lumen is circumferentially disposed around the return line, between an inner diameter of the catheter shaft and an outer diameter of the insulating tube. A position of the insulating tube is fixed relative to the catheter shaft.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 6, 2021
    Inventor: John M. Baust
  • Publication number: 20210113256
    Abstract: A cryogenic medical device is disclosed for use in minimally invasive surgical procedures. Various configurations of cryoprobes are designed in combination with a clamp to form a cryoclamp for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is an integrated cryoablation probe with a hinged clamp that allows for single entry into the chest cavity through a thorascopic port, by surgical or other means. The integrated cryoablation probe allows for the clamping of tissue as well as freezing with a single device. The clamp acts as an outer sheath so that when closed, directional freezing of the cryoprobe is achieved on the opposing probe surface away from the clamp or on an internal surface that is between the clamp. The cryoclamp may be a removable attachment or integrated into the unitary device.
    Type: Application
    Filed: December 11, 2020
    Publication date: April 22, 2021
    Inventors: John M. Baust, John G. Baust, Roy E. Cheeks, Anthony Robilotto
  • Patent number: 10918432
    Abstract: A cryoablation device is provided herein which, in an embodiment, includes a catheter shaft; a cryogen return line disposed within the catheter shaft; and a cryogen supply line disposed within the cryogen return line, such that the cryogen supply line, the cryogen return line, and the catheter shaft are all substantially coaxial. A needle tip probe is disposed at a distal end of the cryogen return line. The cryogen supply line extends in a distal direction beyond a distal end of the cryogen return line and into the needle tip probe, and the catheter shaft is axially movable relative to the needle tip probe and the cryogen return line, and the catheter shaft is configured such that the catheter shaft is distally extended over the needle tip probe in an extended position.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 16, 2021
    Assignee: CPSI HOLDINGS LLC
    Inventor: John M. Baust
  • Publication number: 20200138500
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.
    Type: Application
    Filed: November 18, 2019
    Publication date: May 7, 2020
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Publication number: 20200121498
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 23, 2020
    Inventors: John M. Baust, Roy E. Cheeks, John G. Baust, Anthony Robilotto, Kristi K. Snyder
  • Publication number: 20200030018
    Abstract: An ablation instrument having a longitudinal body with a plurality of sidewalls that form a flexible sleeve, where the plurality of sidewalls that form the flexible sleeve are slotless. The longitudinal body has a proximal end, a distal end, and a central axis. A luminary space is formed within the plurality of sidewalls and at least one internal component is inserted through the proximal end of the longitudinal body and extends through the luminary space to the distal end. The internal component is interconnected with a deflection mechanism for controlling the distal end of the longitudinal body such that the distal end is capable of multi-planar movement.
    Type: Application
    Filed: October 4, 2019
    Publication date: January 30, 2020
    Inventors: John M. Baust, Claudia Lueckge, Roy Cheeks, John G. Baust, Anthony T. Robi
  • Patent number: 10336984
    Abstract: A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Several additive agents (both natural and synthetic) have been identified, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: July 2, 2019
    Assignee: CPSI Holdings LLC
    Inventors: John M. Baust, John G. Baust, William L. Corwin, Robert G. Van Buskirk
  • Publication number: 20190142495
    Abstract: A cryo-fixation lead extraction device includes a lead extraction catheter having longitudinally spaced proximal and distal catheter ends and an elongate catheter lumen. A liner has longitudinally spaced proximal and distal liner ends and an elongate liner lumen. The liner lumen is configured to selectively accept at least part of a lead being extracted longitudinally therethrough. At least a portion of the liner is located circumferentially within and/or circumferentially surrounding the catheter lumen. At least one cryogen supply line extends longitudinally through at least a portion of the liner lumen. The cryogen supply line is configured to place a cryogen fluid source into fluid communication with the distal liner end. The cryogen supply line is configured to selectively generate a patient tissue cooled zone adjacent the distal catheter end. A method of cryo-fixation lead extraction is also provided.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 16, 2019
    Inventors: Oussama Wazni, Marwane Berrada-Sounni, John M. Baust, Kristi K. Snyder
  • Patent number: 10196598
    Abstract: A system for heating or cooling a sample is disclosed, which includes an insulated chamber; at least one of a heater or a cooling pad disposed within the chamber; and at least one compliant, fluid filled pillow. The at least one compliant, fluid-filled pillow is disposed in the chamber and adjacent to the at least one thermal device while being heated or cooled to a desired temperature by the heater or the cooling pad, and upon reaching the desired temperature, the at least one compliant, fluid filled pillow substantially conforms to a container containing the sample.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: February 5, 2019
    Assignee: CPSI HOLDINGS LLC
    Inventors: John M. Baust, Joshua T. Smith, William Corwin, Kristi Snyder, Anthony T. Robilotto
  • Patent number: 10182859
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic probe.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: January 22, 2019
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Publication number: 20180368393
    Abstract: Disclosed herein are conditioning media, supplements for addition to culture or other type of media, and methods for conditioning biological samples before, after, or both before and after preservation for improved recovery outcomes, e.g., cell survival and repopulation. Also disclosed herein are cryoprotective agents and solutions or media containing cryoprotective agents for preservation of biological samples with improved recovery outcomes.
    Type: Application
    Filed: June 26, 2018
    Publication date: December 27, 2018
    Inventors: John M. Baust, Kristi K. Snyder, Robert G. VanBuskirk
  • Publication number: 20180340654
    Abstract: A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 29, 2018
    Inventors: John M. Baust, Joshua T. Smith, Anthony T. Robilotto, Jennie F. McKain
  • Publication number: 20180317994
    Abstract: The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 8, 2018
    Inventors: Marie Molnar-Hammond, John M. Baust
  • Patent number: 10054262
    Abstract: A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: August 21, 2018
    Assignee: CPSI Holdings LLC
    Inventors: John M. Baust, Joshua T. Smith, Anthony T. Robilotto, Jennie F. McKain
  • Patent number: 10039586
    Abstract: The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: August 7, 2018
    Assignee: CPSI Holdings LLC
    Inventors: Marie Molnar-Hammond, John M. Baust
  • Publication number: 20180146999
    Abstract: A cryoablation device is provided herein which, in an embodiment, includes a catheter shaft; a cryogen return line disposed within the catheter shaft; and a cryogen supply line disposed within the cryogen return line, such that the cryogen supply line, the cryogen return line, and the catheter shaft are all substantially coaxial. A needle tip probe is disposed at a distal end of the cryogen return line. The cryogen supply line extends in a distal direction beyond a distal end of the cryogen return line and into the needle tip probe, and the catheter shaft is axially movable relative to the needle tip probe and the cryogen return line, and the catheter shaft is configured such that the catheter shaft is distally extended over the needle tip probe in an extended position.
    Type: Application
    Filed: January 26, 2018
    Publication date: May 31, 2018
    Inventor: John M. Baust
  • Patent number: 9974592
    Abstract: Cryogenic medical devices and apparatus are disclosed which are capable of generating cryogen to a supercritical state, specifically supercritical nitrogen. The cryogenic medical devices and apparatus disclosed are useful in methods of treating damaged, diseased, cancerous or other unwanted tissues.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: May 22, 2018
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy E. Cheeks, Melissa K. Dobson, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
  • Patent number: 9932551
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 3, 2018
    Assignee: CPSI Holdings LLC
    Inventors: John G. Baust, Joshua T. Smith, Kimberly L. Santucci, Kristi K. Snyder, Anthony T. Robilotto, Robert G. Van Buskirk, John M. Baust, William L. Corwin, Jennie F. McKain
  • Patent number: 9895184
    Abstract: The invention is a multi-functional ablation device that encompasses the use of both heat energy and cryogenic energy as integrated into one medical device. In one embodiment, the medical device integrates a heat source such as RF or HIFU in combination with a source of cryogenic energy such that the multi-functional ablation device is a dual thermal ablation device capable of utilizing either energy source alone or in combination.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: February 20, 2018
    Assignee: CPSI Holdings LLC
    Inventor: John M. Baust