Patents by Inventor John M Clemens
John M Clemens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200370097Abstract: The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis).Type: ApplicationFiled: August 11, 2020Publication date: November 26, 2020Inventors: John M. Clemens, Eric B. Shain
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Patent number: 10774376Abstract: The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis).Type: GrantFiled: December 28, 2015Date of Patent: September 15, 2020Assignee: ABBOTT MOLECULAR INC.Inventors: John M. Clemens, Eric B. Shain
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Publication number: 20200123605Abstract: Provided herein are systems and methods for nucleic acid sequencing by synthesis in a plurality of wells using detectably labeled chain terminating nucleotides with photolabile blocking groups and pulses of photocleaving light. In certain embodiments, the systems and methods provides a plurality of deblock-scan cycles comprising an initial deblock time period followed by a scanning light period, wherein at least one of the following occurs in each deblock-scan cycle: 1) the deblock time period is shorter than the scan time period; 2) the deblock time period is only long enough to deblock the photolabile groups that are part of a primer in less than all of the plurality of wells; or 3) the deblock time period is between 25 and 150 mSec and the scan time is at least 200 mSec. Such shorter deblock time periods help prevent the addition of more than one nucleotide to the primer prior to scanning (e.g., accuracy is enhanced).Type: ApplicationFiled: December 23, 2019Publication date: April 23, 2020Inventors: Mark W. Eshoo, John M. Clemens, Mark A. Hayden
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Patent number: 10550428Abstract: Provided herein are systems and methods for nucleic acid sequencing by synthesis in a plurality of wells using detectably labeled chain terminating nucleotides with photolabile blocking groups and pulses of photocleaving light. In certain embodiments, the systems and methods provides a plurality of deblock-scan cycles comprising an initial deblock time period followed by a scanning light period, wherein at least one of the following occurs in each deblock-scan cycle: 1) the deblock time period is shorter than the scan time period; 2) the deblock time period is only long enough to deblock the photolabile groups that are part of a primer in less than all of the plurality of wells; or 3) the deblock time period is between 25 and 150 mSec and the scan time is at least 200 mSec. Such shorter deblock time periods help prevent the addition of more than one nucleotide to the primer prior to scanning (e.g., accuracy is enhanced).Type: GrantFiled: September 16, 2015Date of Patent: February 4, 2020Assignee: IBIS BIOSCIENCES, INC.Inventors: Mark W. Eshoo, John M. Clemens, Mark A. Hayden
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Publication number: 20170247755Abstract: Provided herein are systems and methods for nucleic acid sequencing by synthesis in a plurality of wells using detectably labeled chain terminating nucleotides with photolabile blocking groups and pulses of photocleaving light. In certain embodiments, the systems and methods provides a plurality of deblock-scan cycles comprising an initial deblock time period followed by a scanning light period, wherein at least one of the following occurs in each deblock-scan cycle: 1) the deblock time period is shorter than the scan time period; 2) the deblock time period is only long enough to deblock the photolabile groups that are part of a primer in less than all of the plurality of wells; or 3) the deblock time period is between 25 and 150 mSec and the scan time is at least 200 mSec. Such shorter deblock time periods help prevent the addition of more than one nucleotide to the primer prior to scanning (e.g., accuracy is enhanced).Type: ApplicationFiled: September 16, 2015Publication date: August 31, 2017Inventors: Mark W. Eshoo, John M. Clemens, Mark A. Hayden
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Publication number: 20160130636Abstract: The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis).Type: ApplicationFiled: December 28, 2015Publication date: May 12, 2016Inventors: John M. Clemens, Eric B. Shain
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Patent number: 9222886Abstract: Systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR are provided. In particular, methods to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis) are described.Type: GrantFiled: December 27, 2011Date of Patent: December 29, 2015Assignee: ABBOTT MOLECULAR INC.Inventors: John M. Clemens, Eric B. Shain
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Publication number: 20140302505Abstract: Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: April 25, 2014Publication date: October 9, 2014Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20120215457Abstract: Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: January 13, 2012Publication date: August 23, 2012Inventors: ERIC B. SHAIN, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20120164652Abstract: The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis).Type: ApplicationFiled: December 27, 2011Publication date: June 28, 2012Applicant: IBIS BIOSCIENCES, INC.Inventors: John M. Clemens, Eric B. Shain
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Patent number: 8099243Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: August 11, 2008Date of Patent: January 17, 2012Assignee: Abbott LaboratoriesInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Patent number: 8005625Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: August 11, 2008Date of Patent: August 23, 2011Assignee: Abbott Laboratories, Inc.Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Patent number: 7565250Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: November 17, 2004Date of Patent: July 21, 2009Assignee: Abbott Laboratories Inc.Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20090047679Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: August 11, 2008Publication date: February 19, 2009Applicant: Abbott LaboratoriesInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20080299583Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: August 11, 2008Publication date: December 4, 2008Applicant: ABBOTT LABORATORIESInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20020127727Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.Type: ApplicationFiled: March 7, 2002Publication date: September 12, 2002Inventors: Mark C. Bach, Daniel Bay, Michael K. Carter, John M. Clemens, Daniel G. Dahlke, Charles M. Galitz, Robert C. Gray, Folim Halaka, Steve Herchenbach, Ronald E. Kukla, Curtis J. Pepe, Mark Pierce, Scott G. Safar, Julius Toth, Gary Zuck
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Patent number: 6413780Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.Type: GrantFiled: October 11, 1999Date of Patent: July 2, 2002Assignee: Abbott LaboratoriesInventors: Mark C. Bach, Daniel Bay, Michael K. Carter, John M. Clemens, Daniel G. Dahlke, Charles M. Galitz, Robert C. Gray, Folim Halaka, Steve Herchenbach, Ronald E. Kukla, Curtis J. Pepe, Mark Pierce, Scott G. Safar, Julius Toth, Gary Zuck
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Patent number: 6190617Abstract: A sample container segment assembly for use in an automated, continuous, and random access analytical system is disclosed. The assembly includes a sample container which is received by a sample container segment, and the sample container segment is received on a carousel of the automated analytical instrument. The test sample container includes an upper skirt and a body having a reservoir for receipt of the test sample. The segment includes a base, a frame, and a handle. The frame has a shelf for which the upper skirt of the test sample container rests on, and has openings for receipt of the body of the sample container. The carousel has a carousel trough for receipt of the base of the sample container segment, and has a plurality of alignment pins disposed in the carousel trough. The base of the sample container segment has a circular slot and an elongated slot for receiving the alignment pins and positioning the sample container segment relative to the carousel.Type: GrantFiled: October 23, 1997Date of Patent: February 20, 2001Assignee: Abbott LaboratoriesInventors: Frederick L. Clark, Larry W. Moore, Donny Ray Walker, John M Clemens, William J. Kanewske, III, B. Jane Smith
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Patent number: 5960160Abstract: A liquid heater assembly including a heater body having therein a coiled tube for passing liquids, a pair of heating elements, a thermistor, a thermostat, and a backup thermostat. Liquid enters the coiled liquid tube at an inlet end and exits the coiled liquid tube at an outlet end. The coiled liquid tube is positioned within the heater body between the pair of heating elements. The outlet end extends below a planar surface of the heater body. The thermistor detects the temperature changes of the heater body. The resistance of the thermistor is used to regulate the supply of power to the heating elements. The thermostat and the backup thermostat are connected in series between the power source and the heating elements to provide a safety shutoff when the heater body reaches a predetermined overheat temperature. The heater body is maintained at a predetermined temperature by regulating the electrical current to the heating elements.Type: GrantFiled: December 28, 1995Date of Patent: September 28, 1999Assignee: Abbott LaboratoriesInventors: Frederic L. Clark, Richard R. Martin, Larry W. Moore, John M. Clemens, William D. Rumbaugh, B. Jane Smith
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Patent number: 5762878Abstract: A sample container segment assembly for use in an automated, continuous, and random access analytical system is disclosed. The assembly includes a sample container which is received by a sample container segment, and the sample container segment is received on a carousel of the automated analytical instrument. The test sample container includes an upper skirt and a body having a reservoir for receipt of the test sample. The segment includes a base, a frame, and a handle. The frame has a shelf for which the upper skirt of the test sample container rests on, and has openings for receipt of the body of the sample container. The carousel has a carousel trough for receipt of the base of the sample container segment, and has a plurality of alignment pins disposed in the carousel trough. The base of the sample container segment has a circular slot and an elongated slot for receiving the alignment pins and positioning the sample container segment relative to the carousel.Type: GrantFiled: September 9, 1996Date of Patent: June 9, 1998Assignee: Abbott LaboratoriesInventors: Frederick L. Clark, Kendall B. Hendrick, Richard R. Martin, Larry W. Moore, William J. Raymoure, Paul R. Schrier, Edna S. Walker, Donny Ray Walker, Gary E. Winter, Kevin M. Cloonan, David A. Yost, John M. Clemens, William J. Kanewske, III, Douglas D. McDowell, Carl M. Oleksak, William D. Rumbaugh, B. Jane Smith, James A. Vaught, Apparao Tayi, Robert A. Wohlford, James E. Mitchell, Robert B. Hance, Peter A. Lagocki, Richard A. Merriam, Charles D. Pennington, Linda S. Schmidt, Adrian M. Spronk, Richard L. Vickstrom, William E. Watkins, III, Gilbert Clift, Alyn K. Stanton, David B. Hills