Abstract: Methods and systems directed to dispensing fluids, such as beverages, using wireless technology are provided. Aspects relate to a beverage dispenser with a dispensing system housing, a valve housing positioned exterior to the dispensing system housing and extending from the dispensing system housing. The valve housing may be configured to dispense a beverage and include self-contained electronics disposed within an interior area of the valve housing. In some embodiments, the beverage dispenser has one or more additional valve housings positioned exterior to the dispensing system housing. The valve housing may be configured to dispense a beverage and include self-contained electronics disposed within an interior area of the valve housing.

Abstract: A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

Abstract: A peristaltic pump having at least first, second, and third stages is provided. The peristaltic pump includes a plunger, inlet and outlet valves, a spring, and an actuator. The plunger actuates toward and away from a tube, the inlet valve is upstream of the plunger, the outlet valve is downstream of the plunger, the spring biases the plunger toward the tube, and the actuator mechanically engages and disengages from the plunger. In the first stage, the inlet valve is opened and the plunger is actuated from the tube, in the second stage, the inlet valve is closed, the plunger is actuated toward the tube, and the actuator is mechanically disengaged from the plunger, and in the third stage, the outlet valve is opened. In the third stage or in a fourth stage, the actuator actuates the plunger toward the tube to discharge fluid downstream past the outlet valve.

Abstract: A method for controlling a device using a shape-memory alloy wire is disclosed. The method includes determining an ontime for the shape-memory alloy wire based on a target volume to be pumped by a pump plunger, determining the temperature of the shape-memory alloy wire and adjusting the ontime based on the temperature of the shape-memory alloy wire.

Abstract: A clamp apparatus is disclosed that includes a body, first and second actuators, first, second, third and fourth gear sets, first and second movable grippers, and at least one leaf spring. The first gear set is coupled to the first actuator and the second gear set is coupled to the second actuator. The first gear set engages the second gear set. The first and second movable grippers are each operatively coupled to the body. The third gear set is coupled to the first movable gripper and the fourth gear set is coupled to the second movable gripper. The third gear set operatively engages the fourth gear set. The leaf spring engages with the third gear set and the fourth gear set to urge the first movable gripper and the second movable gripper toward a clamped position.

Abstract: Disclosed are bispecific compounds (degraders) that target ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat diseases and disorders characterized or mediated by aberrant ALK activity.

Abstract: A nozzle for dispensing fluid including a nozzle body having a fluid path therein through which fluid is configured to flow in a downstream direction. The nozzle further includes a valve having a valve body positioned in the fluid path and movable between a closed position wherein the valve body sealingly engages a valve seat to generally block fluid from flowing therethrough, and an open position wherein the valve body is spaced away from the valve seat to generally allow fluid to flow therethrough. At least part of a surface of the valve body positioned upstream of the valve seat is configured to be fluidly isolated from a pressure of fluid in the fluid path upstream of the valve seat when the valve is in the closed position.

Abstract: A syringe pump includes a lead screw, a motor, and a sliding block assembly. The lead screw has threads and the motor is coupled to the lead screw to rotate it. The half-nut housing has a half nut and a barrel cam. The half nut is disposed within the half-nut housing. The half nut has half-nut threads at an end adjacent to the lead screw void. The half nut engages or disengages with the threads of the lead screw. The half nut includes a half-nut cam-follower surface and a half nut slot. The barrel cam is disposed within the half-nut housing and engages with the half-nut cam-follower surface. The barrel cam includes a pin to fit within the half nut slot such that the barrel cam rotates between a first position and a second position to actuate the half nut between the engagement position and the disengagement position, respectively.

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Abstract: A peristaltic pump is disclosed that includes a plunger, a spring, an actuator, a position sensor, and a processor. The plunger actuates toward and away from a tube. The spring biases the plunger toward the tube. The actuator actuates the plunger away from the tube and mechanically engages and disengages from the plunger. The position sensor senses a position of the plunger. The processor receives the sensed position of the plunger and estimates fluid flow within the tube using a first position of the plunger when the actuator is engaged with the plunger and a second position of the plunger when the actuator is disengaged from the plunger.

Abstract: A peristaltic pump includes a plunger-cam follower, a tube receiver, a spring-biased plunger, a spring, a position sensor, and a processor. The plunger-cam follower engages the plunger cam to follow the plunger cam and to disengage from the plunger cam. The spring-biased plunger is coupled to the plunger-cam follower and the spring biases the spring-biased plunger toward the tube receiver. The position sensor determines a position of the spring-biased plunger when the plunger-cam follower is disengaged from the plunger came. The processor estimates fluid flow utilizing at least the position of the spring-biased plunger as indicated by the position sensor when the plunger-cam follower is disengaged from the plunger cam and the spring biases the spring-biased plunger against the tube.

Abstract: A nozzle for dispensing fluid including a nozzle body having a fluid path therein through which fluid is configured to flow in a downstream direction. The nozzle further includes a valve having a valve body positioned in the fluid path and movable between a closed position wherein the valve body sealingly engages a valve seat to generally block fluid from flowing therethrough, and an open position wherein the valve body is spaced away from the valve seat to generally allow fluid to flow therethrough. At least part of a surface of the valve body positioned upstream of the valve seat is configured to be fluidly isolated from a pressure of fluid in the fluid path upstream of the valve seat when the valve is in the closed position.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle has a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path, and a manually operable actuator operatively connectable to the valve. The nozzle also includes a suction generator configured to apply a suction force in the suction path at a suction location. The suction path includes an expansion chamber located upstream of the suction location with respect to a direction of flow in the suction path. A bottom surface of the expansion chamber and a bottom surface of a portion of the suction path positioned immediately upstream of the expansion chamber are generally aligned.

Abstract: A fluid dispensing nozzle system including a nozzle body having a fluid path therein and a fluid valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the fluid valve, and a spout coupled to the nozzle body, the spout having a cavity to allow fluid flowing through the fluid path to pass through the spout. The spout includes a first segment having a first cross sectional area at at least a portion thereof and a second segment having a second cross sectional area at at least a portion thereof that is different than the first cross sectional area. The first segment has transition portion which transitions along a length thereof from the first cross sectional area at one end thereof to the second cross sectional area at a second opposite end thereof, wherein the first segment is made of a separate piece of material than the second segment.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path therein and a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the valve, a spout shell coupled to the nozzle body, and a fluid tube at least partially positioned in the spout shell and in fluid communication with or at least partially defining the fluid path. The nozzle further has a spacer at least partially positioned in the spout shell, a spout tip at least partially positioned in the spout shell, and a seal positioned between the spout tip and the spacer.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle has a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path, and a manually operable actuator operatively connectable to the valve. The nozzle also includes a suction generator configured to apply a suction force in the suction path at a suction location. The suction path includes an expansion chamber located upstream of the suction location with respect to a direction of flow in the suction path. A bottom surface of the expansion chamber and a bottom surface of a portion of the suction path positioned immediately upstream of the expansion chamber are generally aligned.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path therein and a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the valve, a spout shell coupled to the nozzle body, and a fluid tube at least partially positioned in the spout shell and in fluid communication with or at least partially defining the fluid path. The nozzle further has a spacer at least partially positioned in the spout shell, a spout tip at least partially positioned in the spout shell, and a seal positioned between the spout tip and the spacer.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

Abstract: A fluid dispensing nozzle system including a nozzle body having a fluid path therein and a fluid valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the fluid valve, and a spout coupled to the nozzle body, the spout having a cavity to allow fluid flowing through the fluid path to pass through the spout. The spout includes a first segment having a first cross sectional area at at least a portion thereof and a second segment having a second cross sectional area at at least a portion thereof that is different than the first cross sectional area. The first segment has transition portion which transitions along a length thereof from the first cross sectional area at one end thereof to the second cross sectional area at a second opposite end thereof, wherein the first segment is made of a separate piece of material than the second segment.