Abstract: A clamp includes a fixed gripper, a moveable gripper, a driven member, an actuator, and first and second tracks. The driven member is configured to slide within the first and second tracks. The moveable gripper is operatively coupled to the driven member. The actuator is configured to move the driven member towards a first position to thereby move the moveable gripper towards the fixed gripper. The actuator is further configured to move the driven member towards a second position to thereby move the moveable gripper away from the fixed gripper.

Abstract: An acoustic volume sensing device is disclosed. The device includes a housing comprising a reference volume chamber and a variable volume chamber, the reference volume chamber and the variable volume chamber connected by a resonant port, a first MEMS microphone located in acoustic relation to the variable volume chamber, a second MEMS microphone located in acoustic relation to the reference volume chamber, a MEMS speaker located in acoustic relation to the reference volume chamber, and a circuit board in electric connection with the first and second MEMS microphones and the MEMS speaker.

Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

Abstract: An optical stack for sensing a presence of an analyte is provided. The optical stack includes a sensor material. The sensor material includes a first optical response including a first optical property having a second value in response to an excitation signal including the first optical property having a first value different from the second value. The first optical response includes a second optical property sensitive to the presence of the analyte. The optical stack includes a first optical film disposed proximate the sensor material and includes a third optical property having respective third and fourth values in response to the respective first and second values of the first optical property. The third value is different from the fourth value by at least a factor of 2.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A pump for pumping fluid includes a tube platen, a plunger, a bias member, inlet and outlet valves, an actuator mechanism, a position sensor, and a processor. The plunger is configured for actuation toward and away from the infusion-tube when the tube platen is disposed opposite to the plunger. The tube platen can hold an intravenous infusion tube. The bias member is configured to urge the plunger toward the tube platen.

Abstract: A system is disclosed. The system includes a fill adapter device including a heat exchanger which includes a heating element and a fluid pathway, the fluid pathway fluidly connected to a filling needle input, whereby fluid enters the heat exchanger through the filling needle input and flows through the fluid pathway and whereby the fluid is heated by the heating element. The system also includes a reservoir including a plunger and a plunger rod and a filling needle configured to be removably attached to the reservoir, wherein the fill adapter is configured to be attached to a vial of fluid and wherein fluid from the vial flows through the fluid pathway and is heated and loaded into the reservoir through the filling needle.

Abstract: The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, plays a role.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A syringe pump includes a lead screw, a cam, and a grasper. The grasper assembly has first and second graspers arms each having a first end and a second end. The second ends of the first and second grasper arms are configured to engage with the lead screw. The first ends of the first and second grasper arms are configured to engage with the cam such that actuation of the cam toward the grasper assembly causes the second ends of the first and second grasper arms to pivotally approach each other. The second ends of the first and second grasper arms each includes threads to engage the lead screw when the second ends of the first and second grasper arms approach each other. The plunger head coupled to said grasper assembly and operative to drive a plunger of a syringe into a barrel of said syringe.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle has a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path, and a manually operable actuator operatively connectable to the valve. The nozzle also includes a suction generator configured to apply a suction force in the suction path at a suction location. The suction path includes an expansion chamber located upstream of the suction location with respect to a direction of flow in the suction path. A bottom surface of the expansion chamber and a bottom surface of a portion of the suction path positioned immediately upstream of the expansion chamber are generally aligned.

Abstract: A fluid dispensing nozzle system including a nozzle body having a fluid path therein and a fluid valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the fluid valve, and a spout coupled to the nozzle body, the spout having a cavity to allow fluid flowing through the fluid path to pass through the spout. The spout includes a first segment having a first cross sectional area at at least a portion thereof and a second segment having a second cross sectional area at at least a portion thereof that is different than the first cross sectional area. The first segment has transition portion which transitions along a length thereof from the first cross sectional area at one end thereof to the second cross sectional area at a second opposite end thereof, wherein the first segment is made of a separate piece of material than the second segment.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path therein and a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the valve, a spout shell coupled to the nozzle body, and a fluid tube at least partially positioned in the spout shell and in fluid communication with or at least partially defining the fluid path. The nozzle further has a spacer at least partially positioned in the spout shell, a spout tip at least partially positioned in the spout shell, and a seal positioned between the spout tip and the spacer.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path therein and a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the valve, a spout shell coupled to the nozzle body, and a fluid tube at least partially positioned in the spout shell and in fluid communication with or at least partially defining the fluid path. The nozzle further has a spacer at least partially positioned in the spout shell, a spout tip at least partially positioned in the spout shell, and a seal positioned between the spout tip and the spacer.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle has a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path, and a manually operable actuator operatively connectable to the valve. The nozzle also includes a suction generator configured to apply a suction force in the suction path at a suction location. The suction path includes an expansion chamber located upstream of the suction location with respect to a direction of flow in the suction path. A bottom surface of the expansion chamber and a bottom surface of a portion of the suction path positioned immediately upstream of the expansion chamber are generally aligned.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

Abstract: A fluid dispensing nozzle system including a nozzle body having a fluid path therein and a fluid valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the fluid valve, and a spout coupled to the nozzle body, the spout having a cavity to allow fluid flowing through the fluid path to pass through the spout. The spout includes a first segment having a first cross sectional area at at least a portion thereof and a second segment having a second cross sectional area at at least a portion thereof that is different than the first cross sectional area. The first segment has transition portion which transitions along a length thereof from the first cross sectional area at one end thereof to the second cross sectional area at a second opposite end thereof, wherein the first segment is made of a separate piece of material than the second segment.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device having a suction chamber fluidly coupled to the suction path. The shut-off device is configured such that when the suction path is blocked during fluid dispensing the shut-off device prevents the nozzle from dispensing fluid through the fluid path. The suction chamber includes a lip extending around a perimeter thereof. An opening is formed in or extends through the lip, the opening providing fluid communication between the suction chamber and the suction path to enable liquid to flow from the suction chamber to the suction path.

Abstract: A nozzle for dispensing fluid including a nozzle body having a spout and fluid path through which fluid to be dispensed is flowable. The nozzle includes an actuator configured to detect when the spout is sufficiently inserted into a fluid receptacle, and a shut-off device configured to selectively terminate or prevent fluid dispensing operations through the fluid path. The nozzle further includes an interlock operatively coupling the actuator to the shut-off device. The interlock includes a slider that is operatively coupled to the actuator and a pivotable arm that is operatively coupled to the shut-off device, and the slider is slidable along the arm.