Abstract: A peristaltic pump, and related method, are disclosed that includes a cam shaft, a plunger-cam follower, a tube receiver, a spring, a plunger, a door, and a plunger lift lever. The cam shaft includes a plunger cam. The plunger-cam follower engages with the plunger cam of the cam shaft. The spring provides a bias and the plunger is biased toward the tube receiver by the spring. The plunger is coupled to the plunger-cam follower where expansion of the plunger cam along a radial angle intersecting the plunger-cam follower as the cam shaft rotates actuates the plunger away from the tube receiver. The door lever can be actuated between a first position and a second position. The plunger lift lever is coupled to the door lever to actuate the plunger away from the tube receiver when the door lever is actuated to the second position.

Abstract: Disclosed are macrocyclic compounds that possess inhibitory activity against DYRK, TRK, TLK, and/or RET. Also disclosed are pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to treat diseases and disorders that are characterized or mediated by aberrant DYRK, TRK, TLK, and/or RET activity such as cancer, neurodegenerative disorders and genetic disorders.

Abstract: Disclosed are compounds of formula (I) or (II): that inhibit ALK, TRKA, TRKB, TRKC and ROS1. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat disease.

Abstract: The disclosure relates to compounds that act as inhibitors of interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK4); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Abstract: A syringe pump includes a lead screw, a motor, and a sliding block assembly. The lead screw has threads and the motor is coupled to the lead screw to rotate it. The half-nut housing has a half nut and a barrel cam. The half nut is disposed within the half-nut housing. The half nut has half-nut threads at an end adjacent to the lead screw void. The half nut engages or disengages with the threads of the lead screw. The half nut includes a half-nut cam-follower surface and a half nut slot. The barrel cam is disposed within the half-nut housing and engages with the half-nut cam-follower surface. The barrel cam includes a pin to fit within the half nut slot such that the barrel cam rotates between a first position and a second position to actuate the half nut between the engagement position and the disengagement position, respectively.

Abstract: A system for delivery of a volume of infusible fluid. The system includes a controller configured to calculate a trajectory for delivering infusible fluid, the trajectory comprising at least one volume of fluid, and determine a schedule for delivering the at least one volume of fluid according to the trajectory, wherein the schedule comprising an interval and a volume of infusible fluid for delivery. The system also includes a volume sensor assembly for determining the at least one volume of fluid delivered, wherein the controller recalculates the trajectory based on the volume of fluid delivered.

Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

Abstract: An apparatus for determining the volume of fluid dispensed. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and a measurement chamber with a loudspeaker and measures the acoustic response with microphones acoustically coupled to the reference and the measurement chamber. The loudspeaker and sensing microphones are connected to the measurement chamber by separate ports. A detachable dispensing chamber is coupled to the acoustic volume sensor. The volume of the fluid dispensed is determined by a processor based on the acoustic response of the microphones to acoustic excitement by the loudspeaker.

Abstract: A nozzle for dispensing fluid including a nozzle body having a fluid path therein through which fluid is configured to flow in a downstream direction. The nozzle further includes a valve having a valve body positioned in the fluid path and movable between a closed position wherein the valve body sealingly engages a valve seat to generally block fluid from flowing therethrough, and an open position wherein the valve body is spaced away from the valve seat to generally allow fluid to flow therethrough. At least part of a surface of the valve body positioned upstream of the valve seat is configured to be fluidly isolated from a pressure of fluid in the fluid path upstream of the valve seat when the valve is in the closed position.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle has a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path, and a manually operable actuator operatively connectable to the valve. The nozzle also includes a suction generator configured to apply a suction force in the suction path at a suction location. The suction path includes an expansion chamber located upstream of the suction location with respect to a direction of flow in the suction path. A bottom surface of the expansion chamber and a bottom surface of a portion of the suction path positioned immediately upstream of the expansion chamber are generally aligned.

Abstract: A fluid dispensing nozzle system including a nozzle body having a fluid path therein and a fluid valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the fluid valve, and a spout coupled to the nozzle body, the spout having a cavity to allow fluid flowing through the fluid path to pass through the spout. The spout includes a first segment having a first cross sectional area at at least a portion thereof and a second segment having a second cross sectional area at at least a portion thereof that is different than the first cross sectional area. The first segment has transition portion which transitions along a length thereof from the first cross sectional area at one end thereof to the second cross sectional area at a second opposite end thereof, wherein the first segment is made of a separate piece of material than the second segment.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path therein and a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the valve, a spout shell coupled to the nozzle body, and a fluid tube at least partially positioned in the spout shell and in fluid communication with or at least partially defining the fluid path. The nozzle further has a spacer at least partially positioned in the spout shell, a spout tip at least partially positioned in the spout shell, and a seal positioned between the spout tip and the spacer.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path therein and a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the valve, a spout shell coupled to the nozzle body, and a fluid tube at least partially positioned in the spout shell and in fluid communication with or at least partially defining the fluid path. The nozzle further has a spacer at least partially positioned in the spout shell, a spout tip at least partially positioned in the spout shell, and a seal positioned between the spout tip and the spacer.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle has a valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path, and a manually operable actuator operatively connectable to the valve. The nozzle also includes a suction generator configured to apply a suction force in the suction path at a suction location. The suction path includes an expansion chamber located upstream of the suction location with respect to a direction of flow in the suction path. A bottom surface of the expansion chamber and a bottom surface of a portion of the suction path positioned immediately upstream of the expansion chamber are generally aligned.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

Abstract: A fluid dispensing nozzle system including a nozzle body having a fluid path therein and a fluid valve positioned in the fluid path and configured to selectively prevent or allow a flow of fluid through the fluid path. The nozzle further includes a manually operable actuator operatively connectable to the fluid valve, and a spout coupled to the nozzle body, the spout having a cavity to allow fluid flowing through the fluid path to pass through the spout. The spout includes a first segment having a first cross sectional area at at least a portion thereof and a second segment having a second cross sectional area at at least a portion thereof that is different than the first cross sectional area. The first segment has transition portion which transitions along a length thereof from the first cross sectional area at one end thereof to the second cross sectional area at a second opposite end thereof, wherein the first segment is made of a separate piece of material than the second segment.

Abstract: A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device having a suction chamber fluidly coupled to the suction path. The shut-off device is configured such that when the suction path is blocked during fluid dispensing the shut-off device prevents the nozzle from dispensing fluid through the fluid path. The suction chamber includes a lip extending around a perimeter thereof. An opening is formed in or extends through the lip, the opening providing fluid communication between the suction chamber and the suction path to enable liquid to flow from the suction chamber to the suction path.

Abstract: A nozzle for dispensing fluid including a nozzle body having a spout and fluid path through which fluid to be dispensed is flowable. The nozzle includes an actuator configured to detect when the spout is sufficiently inserted into a fluid receptacle, and a shut-off device configured to selectively terminate or prevent fluid dispensing operations through the fluid path. The nozzle further includes an interlock operatively coupling the actuator to the shut-off device. The interlock includes a slider that is operatively coupled to the actuator and a pivotable arm that is operatively coupled to the shut-off device, and the slider is slidable along the arm.