Patents by Inventor John M. Greene

John M. Greene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted protein HEMAE80
    Publication number: 20030065160
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 7, 2001
    Publication date: April 3, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
  • Secreted protein HFEAF41
    Publication number: 20030060619
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 26, 2001
    Publication date: March 27, 2003
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • Secreted protein HKABT24
    Publication number: 20030055236
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 14, 2002
    Publication date: March 20, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Kenneth C. Carter, Yanggu Shi, Craig A. Rosen, Daniel R. Soppet, Hla Kyaw, Ying-Feig Wei, Kimberly A. Florence, D. Roxanne Duan, Charles Florence, John M. Greene, Ping Feng, Ann M. Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni
  • 90 human secreted proteins
    Publication number: 20030054443
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 4, 2001
    Publication date: March 20, 2003
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat, Charles E. Birse
  • 12 human secreted proteins
    Publication number: 20030055231
    Abstract: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 29, 2001
    Publication date: March 20, 2003
    Inventors: Jian Ni, Paul E. Young, Joseph J. Kenny, Henrik S. Olsen, Paul A. Moore, Ying-Fei Wei, John M. Greene, Steven M. Ruben, Ding Liu, Paul R. Crocker
  • Secreted protein HFEAF41
    Publication number: 20030050461
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 1, 2001
    Publication date: March 13, 2003
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Lauie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • 186 human secreted proteins
    Publication number: 20030049618
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: March 16, 2001
    Publication date: March 13, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 64 human secreted proteins
    Publication number: 20030050455
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: February 6, 2001
    Publication date: March 13, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Paul E. Young, John M. Greene, Jian Ni, Ping Feng, Kimberly A. Florence, Jing-Shan Hu, Ann M. Ferrie, Guo-Liang Yu, Roxanne D. Duan, Fouad Janat
  • Precerebellin-like protein
    Patent number: 6525174
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: February 25, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
  • Secreted Protein HODAZ50
    Publication number: 20030027132
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 4, 1998
    Publication date: February 6, 2003
    Inventors: STEVEN M. RUBEN, CRAIG A. ROSEN, CARRIE L. FISCHER, DANIEL R. SOPPET, KENNETH C. CARTER, DANIEL R. BEDNARIK, GREGORY A. ENDRESS, GUO-LIANG YU, JIAN NI, PING FENG, PAUL E. YOUNG, JOHN M. GREENE, ANN M. FERRIE, ROXANNE DUAN, JING-SHAN HU, KIMBERLY A. FLORENCE, HENRIK S. OLSEN, REINHARD EBNER, LAURIE A. BREWER, YANGGU SHI
  • Secreted protein HFEAF41
    Publication number: 20030018180
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: January 31, 2002
    Publication date: January 23, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Lauie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • 90 human secreted proteins
    Publication number: 20030003555
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 1, 2001
    Publication date: January 2, 2003
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat
  • 28 human secreted proteins
    Publication number: 20020172994
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 21, 2002
    Inventors: Steven M. Ruben, Craig A. Rosen, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie L. Fischer, Haodong Li, Daniel R. Soppet, Reiner L. Gentz, Ying-Fei Wei, Paul A. Moore, Paul E. Young, John M. Greene, Ann M. Ferrie
  • Fibroblast growth factor 15 antibodies
    Patent number: 6482408
    Abstract: The present invention relates to antibodies directed to the human protein called Fibroblast Growth Factor 15.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: November 19, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: John M. Greene, Craig A. Rosen
  • Secreted protein HRGDF73
    Publication number: 20020164669
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 19, 2001
    Publication date: November 7, 2002
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
  • Secreted protein HFEAF41
    Publication number: 20020165374
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 29, 2001
    Publication date: November 7, 2002
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Lauie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • Human tumor necrosis factor receptor
    Publication number: 20020150989
    Abstract: A human TNF receptor and DNA (RNA) encoding such receptor and a procedure for producing such receptor by recombinant techniques is disclosed. Also disclosed are methods for utilizing such receptor for screening for antagonists and agonists to the receptor and for ligands for the receptor. Also disclosed are methods for utilizing such agonists to inhibit the growth of tumors, to stimulate cellular differentiation, to mediate the immune response and anti-viral response, to regulate growth and provide resistance to certain infections. The use of the antagonists as a therapeutic to treat autoimmune diseases, inflammation, septic shock, to inhibit graft-host reactions, and to prevent apoptosis is also disclosed. Also disclosed are diagnostic methods for detecting mutations in the nucleic acid sequence encoding the receptor and for detecting altered levels of the soluble receptor in a sample derived from a host.
    Type: Application
    Filed: June 10, 2002
    Publication date: October 17, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: John M. Greene, Robert D. Fleischmann
  • Human tissue inhibitor of metalloproteinase-4
    Patent number: 6448042
    Abstract: A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 10, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: John M. Greene, Craig A. Rosen
  • Human tissue inhibitor of metalloproteinase-4
    Publication number: 20020115187
    Abstract: A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.
    Type: Application
    Filed: April 5, 2002
    Publication date: August 22, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: John M. Greene, Craig A.. Rosen
  • 186 human secreted proteins
    Patent number: 6420526
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: July 16, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel P. Soppet, Kenneth C. Carter, Daniel R. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Yi Li, Zhizhen Zeng, Hla Kyaw