Patents by Inventor John M. Hamlyn

John M. Hamlyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody having binding specificity for human ouabain
    Patent number: 5844091
    Abstract: Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine cell hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: December 1, 1998
    Assignee: University of Maryland, Baltimore
    Inventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William Rodney Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
  • Methods for treating hypertension
    Patent number: 5695756
    Abstract: Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine cell hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 9, 1997
    Assignee: University of Maryland at Baltimore
    Inventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William Rodney Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
  • Immunoassay for detecting human ouabain
    Patent number: 5429928
    Abstract: Methods using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject are disclosed.
    Type: Grant
    Filed: July 28, 1992
    Date of Patent: July 4, 1995
    Assignee: University of Maryland at Baltimore
    Inventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William R. Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
  • Assay methods involving ouabain
    Patent number: 5164296
    Abstract: Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine call hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: November 17, 1992
    Assignee: University of Maryland at Baltimore
    Inventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William R. Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
  • Method for measuring the plasma levels of an inhibitor of (Na.sup.+ +K.sup. +
    Patent number: 4665019
    Abstract: A method for measuring plasma levels of an inhibitor of (Na.sup.+ +K.sup.+)ATPase associated with hypertension comprising:(1) incubating deproteinized plasma of a patient suspected of being hypertensive in a (Na.sup.+ +K.sup.+)ATPase assay solution comprising (a) (Na.sup.+ +K.sup.+)ATPase; and(2) following the activity of the (Na.sup.+ +K.sup.+)ATPase over the course of time, and use of the method in diagnosing hypertension and in monitoring anti-hypertensive therapy.
    Type: Grant
    Filed: August 31, 1983
    Date of Patent: May 12, 1987
    Assignee: University of Maryland
    Inventors: John M. Hamlyn, Mordecai P. Blaustein, A. Avinoam Kowarski