Patents by Inventor John M. Hardham

John M. Hardham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190083604
    Abstract: This invention relates to Hendra virus and Nipah virus immunogenic compositions and methods of use. The invention further relates to immunogenic compositions comprising Hendra virus G glycoprotein, and methods of protecting against Nipah virus infection and disease. The invention also relates to methods of distinguishing subjects vaccinated with the immunogenic compositions of the invention from those infected with Hendra and/or Nipah virus.
    Type: Application
    Filed: June 21, 2018
    Publication date: March 21, 2019
    Inventors: John M. Hardham, Jin-An Huang, Paul J. Dominowski
  • Publication number: 20160266112
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: December 14, 2015
    Publication date: September 15, 2016
    Inventors: Steven J. NORRIS, Jing-Ren ZHANG, John M. HARDHAM, Jerrilyn K. HOWELL, Alan G. BARBOUR, George M. WEINSTOCK
  • Publication number: 20160199482
    Abstract: This invention relates to Hendra virus and Nipah virus immunogenic compositions and methods of use. The invention further relates to immunogenic compositions comprising Hendra virus G glycoprotein, and methods of protecting against Nipah virus infection and disease. The invention also relates to methods of distinguishing subjects vaccinated with the immunogenic compositions of the invention from those infected with Hendra and/or Nipah virus.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 14, 2016
    Inventors: John M. Hardham, Jin-An Huang, Paul J. Dominowski
  • Patent number: 9212218
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: December 15, 2015
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Patent number: 8354240
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: January 15, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jemlyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20120122238
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: December 5, 2011
    Publication date: May 17, 2012
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jemlyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Patent number: 8071109
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: December 6, 2011
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20100317026
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: August 9, 2010
    Publication date: December 16, 2010
    Inventors: STEVEN J. NORRIS, JING-REN ZHANG, JOHN M. HARDHAM, JERRILYN K. HOWELL, ALAN G. BARBOUR, GEORGE M. WEINSTOCK
  • Patent number: 7785597
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: August 31, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20070231341
    Abstract: The present invention provides a method of reducing the major allergen in cat dander, Fel d1, and of reducing allergic response in mammals, including humans, sensitive to cat dander. Specifically to humans sensitive to the Fel d1 allergen that is shed by a cat. The treatment is achieved through administering to the cat itself a composition, which stimulates the cat's immune response to its own dander and Fel d1 polypeptide. The result is a reduction in the amount of Fel d1 shed by the cat, and a subsequent reduction or lowering of the level of allergic responsiveness in sensitized individuals.
    Type: Application
    Filed: March 30, 2007
    Publication date: October 4, 2007
    Inventors: David R. McGavin, John David Haworth, Rajendra Krishnan, John M. Hardham
  • Patent number: 7135176
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: November 14, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Patent number: 6878816
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: April 12, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20040214225
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Patent number: 6740744
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: May 25, 2004
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Patent number: 6719983
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: April 13, 2004
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20040044192
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: August 16, 2002
    Publication date: March 4, 2004
    Applicant: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20030092903
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: July 31, 2002
    Publication date: May 15, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Publication number: 20030060618
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Application
    Filed: August 16, 2002
    Publication date: March 27, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock
  • Patent number: 6437116
    Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the deletion of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: August 20, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Steven J. Norris, Jing-Ren Zhang, John M. Hardham, Jerrilyn K. Howell, Alan G. Barbour, George M. Weinstock