Patents by Inventor John M. Harkin

John M. Harkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioassay for chemicals which generate prooxidant states
    Patent number: 5198336
    Abstract: A bioassay making use of submitochondrial particles to test for the presence of toxic substances which induce prooxidant states in vivo. The assay uses complex I of the electron transport enzymes on the submitochondrial particles which are capable of donating electrons to the toxicant in solution. The presence of any activated oxygen species in the assay solution is detected spectrophotometrically by the adrenochrome reaction.
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: March 30, 1993
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Lynda M. Knobeloch, George A. Blondin, John M. Harkin
  • Bioassay for toxic substances
    Patent number: 4808517
    Abstract: An assay method is disclosed to test for the presence of toxic substances in environmental samples. The assay uses a suspension of mitochondrial membranes carrying enzymes which can be driven by reverse electron transfer to reduce NAD+ to NADH. The competency of the mitochondrial membrane to accomplish this reduction in the presence of the environmental sample is measured spectrophotometrically to test for toxicants.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: February 28, 1989
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: George A. Blondin, John M. Harkin
  • Method for treating septic tank effluent seepage beds and the like
    Patent number: 4021338
    Abstract: A method for correcting and preventing the failure of septic tank effluent seepage beds or similar installations which comprises treating such beds with a solution of an oxidizing agent, preferably hydrogen peroxide.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 3, 1977
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: John M. Harkin