Patents by Inventor John M. Harrison

John M. Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10933056
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: March 2, 2021
    Assignees: Merck Sharp & Dohme Corp., MSD R&D (China) Co. Ltd.
    Inventors: John J. Acton, III, Jianming Bao, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Sandra L. Knowles, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, Michael T. Rudd, Oleg B. Selyutin, David M. Tellers, Ling Tong, Jenny Miu-Chun Wai
  • Publication number: 20200207758
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Application
    Filed: June 22, 2018
    Publication date: July 2, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: John J. ACTON, III, Jianming BAO, Qiaolin DENG, Melissa EGBERTSON, Ronald FERGUSON, II, Xiaolei GAO, Scott Timothy HARRISON, Sandra L. KNOWLES, Chunsing LI, Michael Man-Chu LO, Robert D. MAZZOLA, Jr., Zhaoyang MENG, Meng NA, Michael T. RUDD, Oleg SELYUTIN, David M. TELLERS, Ling TONG, Fengqi ZHANG
  • Publication number: 20200069671
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Application
    Filed: November 5, 2019
    Publication date: March 5, 2020
    Applicants: Merck Sharp & Dohme Corp., MSD R & D (China) Co., Ltd.
    Inventors: John J. Acton, III, Jianming Bao, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Sandra L. Knowles, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, JR., Zhaoyang Meng, Michael T. Rudd, Oleg B. Selyutin, David M. Tellers, Ling Tong, Jenny Miu-Chun Wai
  • Publication number: 20190264567
    Abstract: A modular method of balancing a rotor assembly comprising two or more rotor sub-assemblies comprises dynamically balancing a set of rotor units each comprising one of the rotor sub-assemblies (52) and in which every other rotor sub-assembly is substituted by a respective simulator (54A, 56A). A respective set (55X, 55Y, 55Z) of balancing weights is applied to one or more of the rotor sub-assembly and simulators of a rotor unit (50A) to achieve dynamic balancing such that each set only corrects unbalance contributed by that rotor sub-assembly or simulator to which it is applied. Each set which is applied to a simulator is transferred to the corresponding sub-assembly. The sub-assemblies are then mated to form the balanced rotor assembly. Excitation of flexible modes of the balanced rotor assembly during its rotation is reduced or avoided.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 29, 2019
    Applicant: ROLLS-ROYCE plc
    Inventor: John M. HARRISON
  • Patent number: 8887564
    Abstract: A method for predicting initial unbalance in a component comprising one or more elements, the method comprising: defining a statistical distribution of a mass moment weight of each of the one or more elements; restricting the statistical distribution to a selected range; and calculating an initial unbalance of the component for the restricted distribution of the one or more elements.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: November 18, 2014
    Assignee: Rolls-Royce PLC
    Inventor: John M. Harrison
  • Patent number: 8186057
    Abstract: A method of manufacturing a rotating component, the method comprising the providing a component comprising a first portion, which first portion defines a first cavity, characterised by; identifying a first inertial property of the first portion and/or the entire component, introducing material into the first cavity to achieve an adjusted inertial property of the first portion and hence a desired inertial property of the component. A rotating component including a first portion defining a first cavity, a second portion defining a second cavity, the second portion being circumferentially spaced from said first portion, the first cavity has a first material deposit therein, said material having predetermined inertial characteristics so as to adjust the centre of mass (Z) of the rotating component.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: May 29, 2012
    Assignee: Rolls-Royce, PLC
    Inventors: John M. Harrison, Keith C. Goldfinch
  • Publication number: 20110314909
    Abstract: A method for predicting initial unbalance in a component comprising one or more elements, the method comprising: defining a statistical distribution of a mass moment weight of each of the one or more elements; restricting the statistical distribution to a selected range; and calculating an initial unbalance of the component for the restricted distribution of the one or more elements.
    Type: Application
    Filed: June 15, 2011
    Publication date: December 29, 2011
    Applicant: ROLLS-ROYCE PLC
    Inventor: John M. HARRISON
  • Publication number: 20090035138
    Abstract: A method of manufacturing a rotating component (110), the method comprising the following steps: providing a component comprising a first portion (20, 40, 60, 80, 100, 116), which first portion defines a first cavity (26, 46, 66, 86, 106), characterised by; identifying a first inertial property of the first portion and/or the entire component, introducing material (28, 48, 68, 88, 108) into the first cavity to achieve an adjusted inertial property of the first portion and hence a desired inertial property of the component. A rotating component (110) comprising: a first portion (20, 40, 60, 80, 100, 116) defining a first cavity (26, 46, 66, 86, 106), a second portion (118) defining a second cavity, the second portion being circumferentially spaced from said first portion, characterised in that the first cavity has a first material (28) deposit therein, said material having predetermined inertial characteristics so as to adjust the centre of mass (Z) of the rotating component.
    Type: Application
    Filed: July 7, 2008
    Publication date: February 5, 2009
    Applicant: ROLLS-ROYCE PLC
    Inventors: John M. Harrison, Keith C. Goldfinch
  • Patent number: 5144553
    Abstract: A system for automatic collection of tolls includes a toll facility, an in-vehicle toll processor having memory for storing a toll-money-available quantity purchased by the user, and a toll-facility-identification site that transmits a toll-facility-identifier signal indicating the identity of the upcoming toll facility and the toll to be collected. As the vehicle approaches the identification site, the in-vehicle processor receives the identifier signal and calculates the toll to be debited. When the vehicle passes through the toll facility, the facility transmits a toll-collect signal instructing the in-vehicle toll processor to debit the calculated toll from memory. The in-vehicle processor debits the calculated amount and transmits an acknowledgement signal to the toll facility.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: September 1, 1992
    Inventors: John J. Hassett, John M. Harrison
  • Patent number: 5086389
    Abstract: A system for automatic collection of tolls includes a toll facility, an in-vehicle toll processor having memory for storing a toll-money-available quantity purchased by the user, and a toll-facility-identification site that transmits a toll-facility-identifier signal indicating the identity of the upcoming toll facility and the toll to be collected. As the vehicle approaches the identification site, the in-vehicle processor receives the identifier signal and calculates the toll be be debited. When the vehicle passes through the toll facility, the facility transmits a toll-collect signal instructing the in-vehicle toll processor to debit the calculated toll from memory. The in-vehicle processor debits the calculated amount and transmits an acknowledgement signal to the toll facility.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: February 4, 1992
    Inventors: John J. Hassett, John M. Harrison
  • Patent number: 5037534
    Abstract: A novel flotation aid for use in the flotation removal of contaminates or impurities from mineral slurries. The flotation aid is an alkali aluminate compound. The flotation aid may be incorporated into a flotation reagent system that includes a chemical collector.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: August 6, 1991
    Assignee: J. M. Huber Corporation
    Inventor: John M. Harrison
  • Patent number: 4986113
    Abstract: A liquid tank leakage detection system includes a standpipe and associated measuring pipe together with a sealing connection to the filler pipe of a liquid tank system. A liquid level detector used in cooperation with the measuring pipe includes a float coupled to a measuring beam having one end fixed and the other end coupled to the float. Level changes within the liquid system produce position changes of the float which in turn causes bending or flexing of the beam. A bridge detecting circuit including strain gauges coupled to the flexing beam is operative to provide an output signal indicative of the extent of liquid level changes. A thermocouple is positioned within the liquid tank to provide a temperature compensating signal for use by the measurement system.
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: January 22, 1991
    Assignee: Computerized Tank Testing, Inc.
    Inventors: John M. Harrison, Hubert L. Marshburn, Ron Stout, deceased
  • Patent number: 4849971
    Abstract: A call completion analysis system may be coupled to monitor any of many different kinds of telephone transmission equipment which may use any of a great variety of different kinds of signaling methods. At least one of the monitored equipments being a T-type carrier having a plurality of channels. The system receives and analyzes the variety of signals, including signals on any selected ones or all of the T-type carrier channels. At least some of the analyzed signals relate to call initiation, dial digits, duration, call completion and call abandonment conditions. The system gives both machine and human supervision and read out of the analyzed signals. Calls automatically forwarded to common carriers are monitored to insure correct billing by the office furnishing service to the call.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: July 18, 1989
    Assignee: Tekno Industries, Inc.
    Inventors: Ernest Karras, Peter J. Chiodras, John M. Harrison
  • Patent number: 4794373
    Abstract: An apparatus for visually guiding the occupants of a structure in a path of travel along the floor within a structure is provided. This apparatus is comprised of a carpet overlying the floor, and a lighting strip positioned underneath the carpet. The lighting strip comprises an elongate ribbon, with a group of laterally spaced-apart electrical conductors encased in and extending longitudinally of the ribbon of sheet material. A series of light-transmissive plastic housings are connected to and arranged longitudinally along a common outer surface of the ribbon of plastic sheet material. Light-emitting means are positioned within each of the housings, and are electrically connected to predetermined ones of the group of electrical conductors encased in the ribbon of sheet material. The carpet has holes extending therethrough which are arranged in a series corresponding to the series of light-transmissive housings on the lighting strip.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: December 27, 1988
    Assignee: Collins & Aikman Corporation
    Inventor: John M. Harrison
  • Patent number: 4754372
    Abstract: An illuminable covering of a textile material having a fibrous face with at least one lighting source connected to the back of the textile material is disclosed. A plurality of light-transmissive fibers are connected to the light source and emanate therefrom, with their free end portions terminating adjacent the fibrous face of the textile material for transmitting light thereto when the light source is energized. In a preferred embodiment of the invention, the textile material is a floor covering material such as a carpet or rug.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: June 28, 1988
    Assignee: Collins & Aikman Corporation
    Inventor: John M. Harrison
  • Patent number: 4753088
    Abstract: The open mesh warp knit fabric of the present invention includes a base fabric knit with electrically nonconductive base yarn and forming an open mesh pattern of lightweight construction having spaced openings to provide ventilation therethrough. Electrically conductive filaments are incorporated in the base fabric and provide an open grid extending throughout the entire area of the base fabrics with the conductive filaments being incorporated predominantly in only one side of the base fabric. The conductive yarns provide only about one-half of one percent of the total weight of the fabric and are of a relatively fine denier so that the conductive yarn is substantially invisible to the naked eye. Various types of garments and accessories are illustrated as being formed of the electrostatic dissipating fabric.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: June 28, 1988
    Assignee: Collins & Aikman Corporation
    Inventors: John M. Harrison, Roger R. Varin
  • Patent number: 4737764
    Abstract: An apparatus for guiding the occupants of a structure along a path of travel within the structure is provided. The apparatus is comprised of modular floor covering units which are abuttingly arranged to cover the floor of the structure, with some of the units being signal units having a light-transmissive housing positioned in an opening therein, and having light-emitting means positioned in the housing. Power means are provided to energize the light-emitting means, and thereby provide a visually discernable pathway on the floor. The floor covering units preferably comprise carpet tiles, the light-transmissive housings are preferably formed of molded plastic and the light-emitting means are preferably light-emitting diodes.
    Type: Grant
    Filed: May 30, 1986
    Date of Patent: April 12, 1988
    Assignee: Collins & Aikman Corporation
    Inventor: John M. Harrison
  • Patent number: 4725717
    Abstract: An impact-resistant electrical heating pad is characterized in that both upper and lower surfaces are antistatic. A preferred embodiment of the pad comprises a scrim fabric, a resistance heating wire carried by the scrim fabric, and sheets of high impact plastic material connected to opposing sides of the scrim fabric to form upper and lower plastic sheets. These impact-resistant plastic sheets have electrically conductive particles distributed throughout, so that the sheets themselves are electrically conductive. An electrical conductor is connected to the electrical resistance wire for energizing the same, and is also connected to the plastic sheets for eliminating static electricity from the pad. A ground fault detection circuit is connected to the electrical conductor to interrupt the power supply to the resistance heating wire if a short occurs.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: February 16, 1988
    Assignee: Collins & Aikman Corporation
    Inventor: John M. Harrison
  • Patent number: 4716960
    Abstract: An invention for supplying power to a well. In one embodiment power heats a tubing from adjacent the surface to a selected level to prevent the formation of solids. The tubing is heated by passing an electric current therethrough. In one form the tubing is insulated from the wellhead and the casing down to a selected level where an electrical connection is made between the tubing and casing. Current is applied to the tubing at a point below an insulating tubing collar. In another form an insulated conduit is run into the well to a selected depth and connected to the tubing. Electrical power is connected to the tubing and to the insulated conduit.In another form a sucker rod is electrically insulated from the tubing down to a selected depth. The sucker rod includes a non-conducting section such as a fiberglas sucker rod. A conduit is run through the fiberglas rod and connected to the steel sucker rod therebelow.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: January 5, 1988
    Assignee: Production Technologies International, Inc.
    Inventors: Bernard J. Eastlund, Kenneth J. Schmitt, Ronald M. Bass, John M. Harrison
  • Patent number: 4661689
    Abstract: There is provided an electrical heating pad which includes an encapsulated electrical resistance heater. The upper surface of the pad is comprised of electrically conductive material for imparting antistatic properties to the upper surface of the pad.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: April 28, 1987
    Assignee: Collins & Aikman Corporation
    Inventor: John M. Harrison