Patents by Inventor John M. Hatcher

John M. Hatcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POTENT AND SELECTIVE INHIBITORS OF HER2
    Publication number: 20230295167
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that that are potent and selective inhibitors of HER2. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with HER2.
    Type: Application
    Filed: October 4, 2021
    Publication date: September 21, 2023
    Inventors: Nathanael S. Gray, John M. Hatcher, Alyssa Verano
  • POTENT AND SELECTIVE DEGRADERS OF ALK
    Publication number: 20230158157
    Abstract: Disclosed are bispecific compounds (degraders) that target ALK or ALK and FAK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bispecific compounds to treat diseases and disorders characterized or mediated by aberrant ALK or ALK and FAK activity.
    Type: Application
    Filed: February 24, 2021
    Publication date: May 25, 2023
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: John M. Hatcher, Nathanael S. Gray, Baishan Jiang, Tinghu Zhang, Jianwei Che, Yang Gao, Lyn Howard Jones
  • CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2
    Publication number: 20230137932
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with EGFR and/or HER2 activity.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 4, 2023
    Inventors: Nathanael S. Gray, John M. Hatcher
  • POTENT AND SELECTIVE AZAINDOLE INHIBITORS OF CDK8 AND CDK19
    Publication number: 20230040191
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with CDK8 and/or CDK19.
    Type: Application
    Filed: November 25, 2020
    Publication date: February 9, 2023
    Inventors: Nathanael S. Gray, John M. Hatcher, Prasanna Sreevatsan
  • DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF
    Publication number: 20220409731
    Abstract: Disclosed are bispecific compounds (degraders) that target ALK for degradation.
    Type: Application
    Filed: September 26, 2019
    Publication date: December 29, 2022
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, John M. Hatcher, Chelsea E. Powell, Pasi A. Janne
  • MACROCYCLIC INHIBITORS OF DYRK1A
    Publication number: 20220112201
    Abstract: Disclosed are macrocyclic compounds that possess inhibitory activity against DYRK, TRK, TLK, and/or RET. Also disclosed are pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to treat diseases and disorders that are characterized or mediated by aberrant DYRK, TRK, TLK, and/or RET activity such as cancer, neurodegenerative disorders and genetic disorders.
    Type: Application
    Filed: November 19, 2019
    Publication date: April 14, 2022
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., VORONOI INC.
    Inventors: Nathanael S. Gray, John M. Hatcher, Hwangeun Choi
  • INHIBITORS OF EGFR AND/OR HER2 AND METHODS OF USE
    Publication number: 20220106310
    Abstract: The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, plays a role.
    Type: Application
    Filed: October 20, 2021
    Publication date: April 7, 2022
    Inventors: John M. Hatcher, Nathanael S. Gray, Jaebong Jang, Dries De Clercq, Pasi Janne, Jamie A. Saxon, Michael Eck, David A. Scott, Alyssa Verano
  • MACROCYCLIC INHIBITORS OF ALK, TRKA, TRKB, AND ROS1
    Publication number: 20220033402
    Abstract: Disclosed are compounds that inhibit ALK, TRKA, TRKB, TRKC and ROS1. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat disease.
    Type: Application
    Filed: September 26, 2019
    Publication date: February 3, 2022
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, John M. Hatcher
  • Inhibitors of EGFR and/or HER2 and methods of use
    Patent number: 11186574
    Abstract: The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, plays a role.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: November 30, 2021
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: John M. Hatcher, Nathanael S. Gray, Jaebong Jang, Dries De Clercq, Pasi Janne, Jamie A. Saxon, Michael Eck, David A. Scott, Alyssa Verano
  • INHIBITORS OF EGFR AND/OR HER2 AND METHODS OF USE
    Publication number: 20200199121
    Abstract: The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, plays a role.
    Type: Application
    Filed: August 31, 2018
    Publication date: June 25, 2020
    Inventors: JOHN M. HATCHER, NATHANAEL S. GRAY, JAEBONG JANG, DRIES DE CLERCQ, PASI JANNE, JAMES A. SAXON, MICHAEL ECK, DAVID A. SCOTT, ALYSSA VERANO
  • On demand visibility services and smart directory
    Patent number: 8555407
    Abstract: An on-demand communication system, device, method and program are provided which allows a consumer to request information from an on-demand visibility service. The on-demand visibility service places a request with the on-demand directory service that may then choose a relevant provider to be queried for this information based on situation-based access control logic. The on-demand visibility service then queries the relevant providers with the request for information. Providers may then gather information by optionally using sensors, and may then transmit a provider response to the on-demand visibility service. The on-demand visibility service may then forward this provider response in the form of an answer to the consumer, thereby satisfying the consumer request for information.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: October 8, 2013
    Assignee: Lockheed Martin Corporation
    Inventors: Kathy Villani, Michael E. Gentry, Kathryn Miller, Christopher Pate, James E. Bromhal, Justin C. Kerber, John M. Hatcher
  • On demand visibility services and smart directory
    Publication number: 20110088099
    Abstract: An on-demand communication system, device, method and program are provided which allows a consumer to request information from an on-demand visibility service. The on-demand visibility service places a request with the on-demand directory service that may then choose a relevant provider to be queried for this information based on situation-based access control logic. The on-demand visibility service then queries the relevant providers with the request for information. Providers may then gather information by optionally using sensors, and may then transmit a provider response to the on-demand visibility service. The on-demand visibility service may then forward this provider response in the form of an answer to the consumer, thereby satisfying the consumer request for information.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 14, 2011
    Applicant: LOCKHEED MARTIN CORPORATION
    Inventors: Kathy Villani, Michael E. Gentry, Kathryn Miller, Christopher Pate, James E. Bromhal, Justin C. Kerber, John M. Hatcher