Patents by Inventor John M. Hilfinger

John M. Hilfinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tyrosine-based prodrugs of antiviral agents
    Patent number: 8940313
    Abstract: A tyrosine-based (phosphonylmethoxyalkyl)purine or -pyrimidine conjugate is provided. In some embodiments, the conjugate includes tyrosine based amino acid or dipeptide moieties of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine or its cytosine analog. A method of synthesizing such conjugates based on Boc-protected amino acid or dipeptides is also provided. In addition, a method of isomerizing an (S,S)-diastereoisomer to an (S,R)-diastereoisomer of an amino acid-based or dipeptide-based conjugate by a process including transesterification is provided. A method of inhibiting viral infection and a method of treating viral infection based on (phosphonylmethoxyalkyl)purine or -pyrimidine conjugates is also provided.
    Type: Grant
    Filed: April 23, 2011
    Date of Patent: January 27, 2015
    Assignee: University of Southern California
    Inventors: Charles E. McKenna, Boris A. Kashemirov, Ivan S. Krylov, Michaela Serpi, Valeria M. Zakharova, Larryn W. Peterson, John M. Hilfinger
  • TYROSINE-BASED PRODRUGS OF ANTIVIRAL AGENTS
    Publication number: 20110263535
    Abstract: A tyrosine-based (phosphonylmethoxyalkyl)purine or -pyrimidine conjugate is provided. In some embodiments, the conjugate includes tyrosine based amino acid or dipeptide moieties of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine or its cytosine analogue. A method of synthesizing such conjugates based on Boc-protected amino acid or dipeptides is also provided. In addition, a method of isomerizing an (S,S)-diastereoisomer to an (S,R)-diastereoisomer of an amino acid-based or dipeptide-based conjugate by a process including transesterification is provided. A method of inhibiting viral infection and a method of treating viral infection based on (phosphonylmethoxyalkyl)purine or -pyrimidine conjugates is also provided.
    Type: Application
    Filed: April 23, 2011
    Publication date: October 27, 2011
    Inventors: Charles E. McKenna, Boris A. Kashemirov, Ivan S. Krylov, Michaela Serpi, Valeria M. Zakharova, Larryn W. Peterson, John M. Hilfinger
  • Microsphere encapsulation of gene transfer vectors
    Patent number: 6048551
    Abstract: A controlled release delivery system includes a functional gene vector in a biodegradable polymeric microsphere encapsulating the vector. The present invention further provides a method of making a controlled release delivery system by encapsulating the functional gene vector in a biologically degradable polymeric microsphere.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: April 11, 2000
    Inventors: John M. Hilfinger, Beverly L. Davidson, Steven J. Beer, John R. Crison, Gordon L. Amidon