Abstract: A prefilled, two-constituent system is provided with first and second containers or barrels. The first barrel includes a first chamber having a dispensing end or delivery end. The delivery end defines a dispensing passage or delivery passage communicating through the delivery end to accommodate the dispensing of fluid from the first chamber. A movable seal or reciprocable stopper is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the delivery end and the stopper. A second container or barrel is sized to be disposed in the first barrel and has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the second barrel. A plunger is slidably disposed within the second barrel. A liquid second constituent is provided in the second barrel between the discharge end and the plunger.

Abstract: A prefilled, two-constituent system is provided with a syringe barrel having a dispensing end with an inwardly directed, stationary, piercing cannula. Within the syringe barrel is a first, sealed, collapsible container holding a first constituent at subatmospheric pressure. The first container is slidably disposed within the syringe barrel adjacent the piercing cannula. A second, sealed, collapsible container holding a liquid second constituent is slidably disposed within the syringe barrel spaced from the first container. A carrier is slidably disposed within the syringe barrel between the first and second containers. The carrier has a double-ended, hollow, piercing needle with oppositely extending first and second ends for piercing the first and second containers, respectively. A plunger is slidably mounted within the syringe barrel for applying a force to the second container.

Abstract: A prefilled, two-constituent system is provided with first and second containers. The first container includes a first chamber having a dispensing end. The dispensing end defines a dispensing passage communicating through the dispensing end to accommodate the dispensing of fluid from the first chamber. A movable seal is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the dispensing end and the seal. A second container includes a barrel that is sized to be disposed in the first container and that has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the barrel. A plunger is slidably disposed within the barrel. A liquid second constituent is provided in the barrel between the discharge end and the plunger.