Patents by Inventor John M Morin, Jr.

John M Morin, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating gout with certain indole compounds
    Patent number: 6303610
    Abstract: This invention relates to a method of treating gout with certain indole compounds and other aromatic compounds.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: October 16, 2001
    Assignee: Eli Lilly and Company
    Inventors: Douglas W Johnson, John M Morin, Jr., Jason S Sawyer, Robert T Shuman
  • N,N-diethylglycolamido ester prodrugs of indole sPLA2 inhibitors
    Patent number: 6274616
    Abstract: The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid N,N-diethylglycolamido ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: August 14, 2001
    Assignee: Eli Lilly and Company
    Inventors: Michael L Denney, John M Morin, Jr., Daniel J Sall, Jason S Sawyer
  • Compounds and methods for inhibition of HIV and related viruses
    Patent number: 5714503
    Abstract: Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: February 3, 1998
    Assignee: Medivir AB
    Inventors: John M. Morin, Jr., Robert J. Ternansky, Rolf Noreen, Peter Tomas Lind
  • Compounds and methods for inhibition of HIV and related viruses
    Patent number: 5658907
    Abstract: Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: August 19, 1997
    Assignee: Medivir A/B
    Inventors: John M. Morin, Jr., Robert J. Ternansky, Rolf Noreen, Peter Tomas Lind
  • Glycoprotein IIb/IIIa antagonists
    Patent number: 5618843
    Abstract: This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: April 8, 1997
    Assignee: Eli Lilly and Company
    Inventors: Matthew J. Fisher, Anne M. Happ, Joseph A. Jakubowski, Michael D. Kinnick, Allen D. Kline, John M. Morin, Jr., Daniel J. Sall, Marshall A. Skelton, Robert T. Vasileff
  • Method for inhibition of HIV related viruses
    Patent number: 5593993
    Abstract: Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: January 14, 1997
    Assignee: Medivir AB
    Inventors: John M. Morin, Jr., Robert J. Ternansky, Rolf Noreen, Tomas Lind
  • Process for preparing 4-substituted azetidinones
    Patent number: 5106475
    Abstract: A process for preparing 3-4-cis-.beta.,.beta.-(4)-substituted and 3-4-trans,.beta.,.alpha.-(4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: April 21, 1992
    Assignee: Eli Lilly and Company
    Inventors: John M. Morin, Jr., Robert J. Ternansky, David A. Hall
  • Process for preparing 4-substituted azetidinones
    Patent number: 4992545
    Abstract: A process for preparing 3-4-cis-.beta.,.beta.-(4)-substituted and 3-4-trans,.beta.,.alpha.- (4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: February 12, 1991
    Assignee: Eli Lilly and Company
    Inventors: David A. Hall, deceased, John M. Morin, Jr., Robert J. Ternansky
  • Photochemical conversion of cephalosporins, 1-carba(1-dethia)cephalosporins and 1-oxa(1-dethia)cephalosporins
    Patent number: 4888100
    Abstract: A process for photochemically converting 3-exomethylene cephams (or 1-carba(1-dethia)cephams or and 1-oxa(1-dethia)cephams) from the corresponding 3-alkyl-3-cephem (or 1-carba(1-dethia)cephem or 1-oxa(1-dethia)cephem) is provided. Further provided are 3-cephams useful as intermediates to 3-cephem compounds.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: December 19, 1989
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, John M. Morin, Jr., Robert T. Vasileff
  • Azetidinone intermediates for 1-carba(dethia)caphalosporins
    Patent number: 4885362
    Abstract: Azetidinone-2 intermediates represented by the formula ##STR1## wherein R is phenyl, phenoxy or thienyl, R.sub.1 is --CH.dbd.CH--COOR.sub.1 ' wherein R.sub.1 ' is an ester, e.g., benzyl; --CH.sub.2 CH.sub.2 COR.sub.2 wherein R.sub.2 is OH or imidazol-1-yl; --CH.sub.2 CH.sub.2 C(O)CH.sub.2 COOR.sub.1 ' where R.sub.1 ' is an ester, e.g., p-nitrobenzyl; and R', R" and R'" are C.sub.1 -C.sub.4 alkyl, aryl or aralkyl; are converted to 1-carba(dethia)cephalosporin antibiotics. Preferably, R is phenoxy and the 1-silyl group is dimethyl-t-butylsilyl. Also provided is 3.beta.-phenoxyacetylamino-4.beta.-(2-carboxyethyl)azetidinone, likewise useful in the preparation of 1-carbacephalosporin antibiotics.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: December 5, 1989
    Assignee: Eli Lilly and Company
    Inventors: John M. Morin, Jr., William C. Vladuchick
  • 3-thiazolomethyl cephalosporins as antibiotics
    Patent number: 4665066
    Abstract: 7.beta.-[2-(2-Aminothiazol(oxazol)-4-yl)-2-oximinoacetamido]-3-(thiazolium or substituted thiazolium-3-yl)methyl-3-cephem-4-carboxylates and the correspondingly substituted 1-oxadethia and 1-carbadethia 3-cephem compounds are potent antibacterials useful in a therapeutic method for treating bacterial diseases. Also provided are pharmaceutical formulations of these thiazolium-substituted compounds and intermediates useful in the preparation thereof.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: May 12, 1987
    Assignee: Eli Lilly and Company
    Inventor: John M. Morin, Jr.
  • Preparation of oxazolines
    Patent number: 4587053
    Abstract: Oxazolino-azetidinones are prepared by reaction of a phosphorus compound with a 3-exomethylenecepham sulfoxide.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: May 6, 1986
    Assignee: Eli Lilly and Company
    Inventors: Robin D. G. Cooper, John M. Morin, Jr., Lynn R. Peters