Abstract: Lithium titanate is made by heating to a temperature of at least 715 C., powder form lithium carbonate and titanium dioxide while mixing, for instance in a rotary kiln. The product is formulated into extended release oral pharmaceutical compositions. Lithium ions are released by zero order rate characteristics from the compositions. The composition can have increased density to extend retention in the stomach. The compositions are used for treatment of manic depressive illness.

Abstract: A process for binding water-sensitive active materials in essentially non-aqueous systems.

Abstract: The residence time in the human stomach of a pharmaceutical, gastric controlled release unit can be increased significantly if the units has a density that is much higher than normal. A preferred oral dosage form according to the invention comprises tablet. The density of the unit is preferably at least 2.5 and usually at least 2.7 g/ml and can conveniently be achieved by including at least 50% by weight of a weighting agent such as barium sulphate.

Abstract: The residence time in the human stomach of pharmaceutical, gastric controlled release, solid units can be increased significantly if the units have a density that is much higher than normal. A preferred oral dosage form according to the invention comprises a capsule or other dosage form having a dimension above 2 mm and that contains one or more of the said units. The density of each unit is preferably at least 2.5 and usually at least 2.7 g/ml and can conveniently be achieved by including at least 50% by weight of a weighting agent such as barium sulphate.