Patents by Inventor John M. Ostresh

John M. Ostresh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
    Patent number: 5856107
    Abstract: The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
    Type: Grant
    Filed: February 4, 1997
    Date of Patent: January 5, 1999
    Assignee: Trega Biosciences, Inc.
    Inventors: John M. Ostresh, Richard A. Houghten
  • Peralkylated oligopeptide mixtures
    Patent number: 5846731
    Abstract: Linear peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: December 8, 1998
    Assignee: Torry Pines Institute for Molecular Studies
    Inventors: Richard A. Houghten, John M. Ostresh
  • Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
    Patent number: 5786448
    Abstract: The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: July 28, 1998
    Assignee: Trega Biosciences, Inc.
    Inventors: Adel Nefzi, John M. Ostresh, Richard Houghten
  • Synthesis of quinazolinone libraries and derivatives thereof
    Patent number: 5783577
    Abstract: The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: July 21, 1998
    Assignee: Trega Biosciences, Inc.
    Inventors: Richard A. Houghten, John M. Ostresh
  • Peralkylated oligopeptide mixtures
    Patent number: 5763193
    Abstract: Linear C.sub.1 -C.sub.7 -alkyl peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C.sub.1 -C.sub.7 -alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: June 9, 1998
    Assignee: Torrey Pines Institute for Molecular Studies
    Inventors: Richard A. Houghten, John M. Ostresh, Sylvie Blondelle
  • Peralkylated oligopeptide mixtures
    Patent number: 5480971
    Abstract: Linear C.sub.1 -C.sub.7 -alkyl peralkylated oligopeptide sets of molecules are specific peralkylated oligopeptides, disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C.sub.1 -C.sub.7 -alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides such as those having 5-8 phenylalanine residues that have antimicrobial properties.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: January 2, 1996
    Assignee: Houghten Pharmaceuticals, Inc.
    Inventors: Richard A. Houghten, John M. Ostresh, Sylvie Blondelle