Patents by Inventor John M. Peltier

John M. Peltier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinoxaline derivatives as antitumor agents
    Patent number: 8518959
    Abstract: The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: August 27, 2013
    Assignee: Prolexys Pharmaceuticals, Inc.
    Inventors: Robert R. Becklin, Cindy Lou Chepanoske, John M. Peltier, Longwu Qi, Paul B. Robbins, Sudhir R. Sahasrabudhe, Robert Selliah, Keith Simmon, Brent R. Stockwell, Raj Gopal Venkat, Moritz von Rechenberg, Eugene Y. Zhen
  • Method for purification of a protein complex and identification of its components
    Patent number: 7825227
    Abstract: The present invention provides a method for purifying a protein complex and the components comprising the complex from a cell, a cell or tissue lysate or a whole organism by employing a combined set of affinity tags of high affinity, specificity and ease of elution. The method involves using a protein or a peptide modified to contain one or more affinity tags separated by one or more specific protease cleavage sites to isolate any interacting proteins or fragments thereof. Specifically exemplified is a method employing a modified bait containing AviTag or GST and a removal tag of His6 hexapeptide positioned proximal to the bait such that any excess bait can be efficiently removed from the purified complex yielding enriched interacting proteins prior to subjecting the complex for further identification of individual components. The identification of the proteins or fragments thereof contained in the protein complex will provide new targets for the identification of new pharmaceuticals and diagnostic tools.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: November 2, 2010
    Assignee: Prolexys Pharmaceuticals, Inc.
    Inventors: John J. Boniface, Vladimir Kery, John M. Peltier, Paul B. Robbins, Justin Savage, Moritz Von Rechenberg
  • Quinoxaline Derivatives as Antitumor Agents
    Publication number: 20090214465
    Abstract: The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
    Type: Application
    Filed: January 25, 2006
    Publication date: August 27, 2009
    Applicants: PROLEXYS PHARMACEUTICALS, INC., WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF
    Inventors: Robert R. Becklin, Cindy Lou Chepanoske, John M. Peltier, Longwu Qi, Paul B. Robbins, Sudhir R. Sahasrabudhe, Robert Selliah, Keith Simmon, Brent R. Stockwell, Raj Gopal Venkat, Moritz von Rechenberg, Eugene Y. Zhen
  • Non-peptidyl agents with pHSP20-like activity, and uses thereof
    Publication number: 20090136561
    Abstract: The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.
    Type: Application
    Filed: October 20, 2008
    Publication date: May 28, 2009
    Applicant: Prolexys Pharmaceuticals, Inc.
    Inventors: Moritz von Rechenberg, John M. Peltier, Sudhir R. Sahasrabudhe, Srdjan Askovic, Robert Selliah, Thomas Zarembinski
  • Method for Calibrating an Analytical Instrument
    Publication number: 20080201095
    Abstract: Methods are provided for calibrating analytical instruments that comprise a quantitative device, such as spectrometers, particularly where a complex mixture is analyzed over a broad spectral range. Associated computer and analytical systems as well as software are also provided.
    Type: Application
    Filed: February 12, 2008
    Publication date: August 21, 2008
    Inventors: Ping F. Yip, Brian C. Mansfield, John M. Peltier, Paolo Lecchi, Greg P. Bertenshaw, Wesley S. Wiggins