Patents by Inventor John M. Pezzuto

John M. Pezzuto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemotherapeutic flavonoids, and syntheses thereof
    Patent number: 8946287
    Abstract: Substituted flavonoid compounds, and pharmaceutical formulations of flavonoid compounds are described. Also described are processes for preparing flavonid compounds, as are methods for treating cancer in mammals using the described flavonoid compounds or pharmaceutical formulations thereof.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: February 3, 2015
    Assignee: Purdue Research Foundation
    Inventors: Mark S. Cushman, John M. Pezzuto, Arup Mati
  • CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF
    Publication number: 20100099755
    Abstract: Substituted flavonoid compounds, and pharmaceutical formulations of flavonoid compounds are described. Also described are processes for preparing flavonid compounds, as are methods for treating cancer in mammals using the described flavonoid compounds or pharmaceutical formulations thereof.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 22, 2010
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Mark S. Cushman, John M. Pezzuto, Arup Maiti
  • Method and composition for selectively inhibiting melanoma
    Patent number: 7414042
    Abstract: Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally applied topically is inserted therefor.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: August 19, 2008
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: John M. Pezzuto, Tapas K. DasGupta, Darrick S. H. L. Kim
  • Method of preparing and use of prodrugs of betulinic acid derivatives
    Patent number: 7091195
    Abstract: A composition and method of preventing or inhibiting tumor growth and, more particularly, of treating a malignant tumor, using prodrugs of plant-derived compounds and derivatives is disclosed. In the method, a composition containing betulinic acid or a betulinic acid derivative is administered in a prodrug form to release betulinic acid or a betulinic acid derivative in vivo at the tumor site.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: August 15, 2006
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John M. Pezzuto, Jerome W. Kosmeder, II, Ze-Qi Xu, Nian E. Zhou, Miriam Elaine Goldsmith
  • Tropane alkaloid multidrug resistance inhibitors from and use of the same
    Patent number: 6989396
    Abstract: Compounds and methods of modulating the activity of P-glycoproteins are disclosed. The method utilizes compounds derived from Erythroxylum pervillei. The compounds overcome multidrug resistance and can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: January 24, 2006
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: A. Douglas Kinghorn, John M. Pezzuto, Baoliang Cui, Gloria L. Silva, Min You
  • Aromatase inhibitors from Broussonetia papyrifera
    Patent number: 6737439
    Abstract: A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammals, including humans.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: May 18, 2004
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Alan Douglas Kinghorn, John M. Pezzuto, Dongho Lee, Krishna P. L. Bhat
  • Method of preparing and use of prodrugs of betulinic acid derivatives
    Publication number: 20030186945
    Abstract: A composition and method of preventing or inhibiting tumor growth and, more particularly, of treating a malignant tumor, using prodrugs of plant-derived compounds and derivatives is disclosed. In the method, a composition containing betulinic acid or a betulinic acid derivative is administered in a prodrug form to release betulinic acid or a betulinic acid derivative in vivo at the tumor site.
    Type: Application
    Filed: January 13, 2003
    Publication date: October 2, 2003
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John M. Pezzuto, Jerome W. Kosmeder, Ze-Qi Xu, Nian En Zhou, Miriam Elaine Goldsmith
  • Method and composition for selectively inhibiting melanoma
    Publication number: 20030181429
    Abstract: A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
    Type: Application
    Filed: December 12, 2002
    Publication date: September 25, 2003
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John M. Pezzuto, Tapas K. DasGupta, Darrick S.H.L. Kim
  • Cancer chemopreventative compounds and compositions and methods of treating cancers
    Publication number: 20030149096
    Abstract: A composition and method of treating multiple myeloma are disclosed. The composition and method utilize brusatol, bruceantin, glaucarubolone, and derivatives thereof as active multiple myeloma treating agents in mammals, including humans.
    Type: Application
    Filed: July 22, 2002
    Publication date: August 7, 2003
    Inventors: John M. Pezzuto, James D. McChesney, Muriel Anne Cuendet, Lawrence Helson
  • Aromatase inhibitors from Broussonetia papyrifera
    Publication number: 20030125377
    Abstract: A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammals, including humans.
    Type: Application
    Filed: July 25, 2002
    Publication date: July 3, 2003
    Inventors: Alan Douglas Kinghorn, John M. Pezzuto, Dongho Lee, Krishna P.L. Bhat
  • Method of preparing and use of prodrugs of betulinic acid derivatives
    Patent number: 6569842
    Abstract: A composition and method of preventing or inhibiting tumor growth and, more particularly, of treating a malignant tumor, using prodrugs of plant-derived compounds and derivatives is disclosed. In the method, a composition containing betulinic acid or a betulinic acid derivative is administered in a prodrug form to release betulinic acid or a betulinic acid derivative in vivo at the tumor site.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: May 27, 2003
    Assignee: Board of Trustees of the University of Illinois, The
    Inventors: John M. Pezzuto, Jerome W. Kosmeder, II, Ze-Qi Xu, Nian En Zhou, Miriam Elaine Goldsmith
  • Tropane alkaloid multidrug resistance inhibitors from Erythroxylum pervillei and use of the same
    Publication number: 20030092729
    Abstract: Compounds and methods of modulating the activity of P-glycoproteins are disclosed. The method utilizes compounds derived from Erythroxylum pervillei. The compounds overcome multidrug resistance and can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics.
    Type: Application
    Filed: April 10, 2002
    Publication date: May 15, 2003
    Inventors: A. Douglas Kinghorn, John M. Pezzuto
  • Cancer chemopreventative compounds and compositions and methods of treating cancers
    Publication number: 20020193425
    Abstract: A composition and method of cancer treatment is disclosed. The composition and method utilize brusatol, bruceantin, glaucarubolone, and derivatives thereof as active cancer treating agent in mammals, including humans.
    Type: Application
    Filed: February 4, 2002
    Publication date: December 19, 2002
    Inventors: John M. Pezzuto, James D. McChesney
  • Method and composition for selectively inhibiting melanoma
    Patent number: 6495600
    Abstract: A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: December 17, 2002
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John M. Pezzuto, Tapas K. DasGupta, Darrick S. H. L. Kim
  • Pharmaceutical formulations of resveratrol
    Publication number: 20020173472
    Abstract: A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.
    Type: Application
    Filed: February 7, 2002
    Publication date: November 21, 2002
    Inventors: John M. Pezzuto, Richard C. Moon, Mei-Shiang Jang, Aomar Ouali, Shengzhao Lin, Karla Slowing Barillas
  • Pharmaceutical formulations of resveratrol and methods of use thereof
    Patent number: 6414037
    Abstract: A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: July 2, 2002
    Assignee: Pharmascience
    Inventors: John M. Pezzuto, Richard C. Moon, Mei-Shiang Jang, Aomar Ouali, Shengzhao Lin, Karla Slowing Barillas
  • Method of preparing and use of prodrugs of betulinic acid derivatives
    Publication number: 20020052352
    Abstract: A composition and method of preventing or inhibiting tumor growth and, more particularly, of treating a malignant tumor, using prodrugs of plant-derived compounds and derivatives is disclosed. In the method, a composition containing betulinic acid or a betulinic acid derivative is administered in a prodrug form to release betulinic acid or a betulinic acid derivative in vivo at the tumor site.
    Type: Application
    Filed: August 15, 2001
    Publication date: May 2, 2002
    Inventors: John M. Pezzuto, Jerome W. Kosmeder, Ze-Qi Xu, Nian En Zhou, Miriam Elaine Goldsmith
  • Method and composition for selectively inhibiting melanoma
    Patent number: 6225353
    Abstract: A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: May 1, 2001
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John M. Pezzuto, Tapas K. DasGupta, Darrick S. H. L. Kim
  • Use of 4'-bromoflavone in a cancer chemopreventative composition and method
    Patent number: 6046231
    Abstract: A composition and method of cancer chemoprevention is disclosed. The composition and method utilize 4'-bromoflavone as a cancer chemo-preventative agent in mammals, including humans.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: April 4, 2000
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jerome W. Kosmeder, II, Robert M. Moriarty, John M. Pezzuto, Lynda Li Song, Richard C. Moon
  • Cancer chemopreventative composition and method
    Patent number: 6008260
    Abstract: A composition and method of cancer chemoprevention is disclosed. The composition and method utilize resveratrol as a cancer chemopreventative agent in mammals, including humans.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: December 28, 1999
    Assignee: Pharmascience
    Inventors: John M. Pezzuto, Richard C. Moon, Mei-Shiang Jang