Patents by Inventor John M. Risley

John M. Risley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 1-amino-1-deoxyoligosaccharides and derivatives thereof
    Patent number: 5283353
    Abstract: The invention resides in oligosaccharide derivatives which are obtained by the enzynmatic cleavage of carbohydrates linked to proteins through asparagine groups. The oligosaccharide moieties of the instant invention are 1-amino-1-deoxyoligosaccharide compounds which are cleaved from a glycoprotein with an aminohydrolase enzyme, wherein the amino group of the oligosaccharide is subsequently substituted with a fluorescent reporter compound. The compounds of the instant invention are characterized by the glycosylamine bonds exhibiting less than 10% hydrolysis at 25.degree. C. in aqueous solution over a two days at pH values between 4-10.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: February 1, 1994
    Assignees: Genzyme Corporation, Purdue Research Foundation
    Inventors: James R. Rasmussen, John M. Risley, Robert L. Van Etten