Patents by Inventor John M. Rolf

John M. Rolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for separating &agr;1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
    Patent number: 6284874
    Abstract: The present invention is directed to a process for purifying &agr;1-proteinase inhibitor. The process comprises providing an impure protein fraction which comprises &agr;1-proteinase inhibitor. The impure protein fraction is precipitated with a precipitant comprising PEG. The supernatant from the PEG precipitation, which comprises &agr;1-proteinase inhibitor, is collected and applied to an anion-exchange medium. A fraction comprising &agr;1-proteinase inhibitor is recovered from the anion-exchange medium and applied to a metal chelate medium. A fraction comprising &agr;1-proteinase inhibitor is then recovered from the metal chelate medium. Alpha1-proteinase inhibitor purified by the process has a specific activity greater than 0.6 units/mg.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: September 4, 2001
    Assignee: Alpha Therapeutic Corporation
    Inventors: T. (Tom) Taniguchi, John M. Rolf, Prabir Bhattacharya, Yahiro (Roy) Uemura
  • Manufacturing process for the production of purified transferrin
    Patent number: 5744586
    Abstract: Method for obtaining highly purified transferrin from a partially purified plasma fraction containing transferrin in which the starting fraction is concentrated. Its ionic strength is reduced and then transferrin is adsorbed onto a chromatographic column. Following elution, the transferrin can be further processed through to packaging in final containers. The final purified transferrin product is sterile, at least 95% pure and is substantially free of enveloped and non-enveloped viruses.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: April 28, 1998
    Assignee: Alpha Therapeutic Corporation
    Inventors: John M. Rolf, Akimasa Ohmizu, Shawn D. Latham, Prabir Bhattacharya