Patents by Inventor John M. Sedivy

John M. Sedivy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating, preventing or reversing age associated inflammation and disorders
    Patent number: 11793814
    Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: October 24, 2023
    Assignee: Brown University
    Inventors: John M. Sedivy, Marco De Cecco
  • COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDERS
    Publication number: 20230139684
    Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one LINE 1 (L-1) endonuclease inhibitor.
    Type: Application
    Filed: November 23, 2020
    Publication date: May 4, 2023
    Inventors: John M. SEDIVY, Gerwald JOGL, Alexandra D'ORDINE
  • Composition and Methods for Treating Articulating Joint Disorders with Nucleoside Reverse Transcriptase Inhibitors
    Publication number: 20210379092
    Abstract: Described herein is are compositions and methods for treating an articulating joint disorders, comprising systemically administering to a subject a nucleoside reverse transcriptase inhibitor (NRTI).
    Type: Application
    Filed: May 13, 2019
    Publication date: December 9, 2021
    Inventors: Qian Chen, Yun Gao, John M. Sedivy, Marco De Cecco
  • COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE ASSOCIATED INFLAMMATION AND DISORDERS
    Publication number: 20210106586
    Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).
    Type: Application
    Filed: July 21, 2020
    Publication date: April 15, 2021
    Inventors: John M. SEDIVY, Marco DE CECCO
  • Kinase inhibitors and methods of use in screening assays and modulation of cell proliferation and growth
    Patent number: 6864224
    Abstract: The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. The RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family medicated regulation.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: March 8, 2005
    Assignee: Brown University Research Foundation
    Inventors: John M. Sedivy, Walter Kolch, Kam Chi Yeung
  • Transcriptional regulation of kinase inhibitors
    Publication number: 20040180341
    Abstract: The invention relates to the transcriptional regulation of a family of proteins defined by the presence of an RKIP motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. Transcriptional regulation of proteins containing an RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family mediated regulation.
    Type: Application
    Filed: March 7, 2003
    Publication date: September 16, 2004
    Applicant: Brown University
    Inventors: John M. Sedivy, Walter Kolch, Kam Chi Yeung
  • Kinase inhibitors and methods of use in screening assays and modulation of cell proliferation and growth
    Publication number: 20040018570
    Abstract: The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. The RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family mediated regulation.
    Type: Application
    Filed: March 6, 2003
    Publication date: January 29, 2004
    Applicant: Brown University
    Inventors: John M. Sedivy, Walter Kolch, Kam Chi Yeung