Abstract: A cell culturing device includes a plurality of trays that are stacked on top of each other, each of the plurality of trays having a floor and an upstanding encircling sidewall, the floor and the encircling sidewall of each tray bounding a space configured to hold a liquid cell culture medium, the plurality of trays comprising a top tray, a bottom tray and one or more intermediate trays disposed therebetween. The bottom tray and the one or more intermediate trays each have a first venting port extending upwardly from the floor thereof, each first venting port bounding a channel passing through the floor of the corresponding tray and being in fluid communication with an adjacent tray. The channel of the bottom tray is openly exposed so that a gas can flow from the space of the bottom tray through the channel of the bottom tray.

Abstract: A system and method of adjusting control parameters for a catheter including receiving sensor data from a sensor on a distal portion of a catheter, detecting a location of the distal portion of the catheter within a luminal network of a patient, determining a shape of the catheter within the luminal network of the patient, modifying control parameters of a drive motor operably coupled to the catheter based on the detected location of the distal portion of the catheter and the determined shape of the catheter within the luminal network of the patient.

Abstract: A control system, including a controller having a display and a handle detachably coupled to the display and including an input device, a motor assembly, wherein the display is detachably coupled to the motor assembly, the motor assembly including a drive motor in communication with the handle, and a catheter drive detachably coupled to the motor assembly, wherein actuation of the drive motor effectuates movement of a catheter operatively coupled to the catheter drive.

Abstract: A cell culturing device includes a plurality of trays that are stacked on top of each other, each of the plurality of trays having a floor and an upstanding encircling sidewall, the floor and the encircling sidewall of each tray bounding a space configured to hold a liquid cell culture medium, the plurality of trays comprising a top tray, a bottom tray and one or more intermediate trays disposed therebetween. The bottom tray and the one or more intermediate trays each have a first venting port extending upwardly from the floor thereof, each first venting port bounding a channel passing through the floor of the corresponding tray and being in fluid communication with an adjacent tray. The channel of the bottom tray is openly exposed so that a gas can flow from the space of the bottom tray through the channel of the bottom tray.

Abstract: A cell culture device (10) of the cultivation of cells. The cell culture device (10) includes a plurality of trays (12a, 12b, 12c, 12d), each tray (12a, 12b, 12c, 12d) having a cell growth surface (20) and at least one wall (22, 24) extending upwardly from the cell growth surface (20). The at least one wall (22, 24) is configured to receive an additional tray thereon. A ratio of the number of the plurality of trays (12a, 12b, 12c, 12d) per a height dimension of the plurality of trays (12a, 12b, 12c, 12d) is greater than or equal to about 1 tray per 12 mm.

Abstract: A closure (10, 100, 150) for a labware device (20). The labware device (20) defines an interior chamber (25) having at least one opening (92). The closure (10, 100, 150) includes a closure body (12, 102) configured to be mounted to the labware device (20) and in fluid communication with the opening (92). A vent valve (14, 122) is mounted for movement relative to the closure body (12, 102). The vent valve (14, 122), with the closure body (12, 102), defines a space (72, 120) that defines a path between the closure body (12, 102) and the vent valve (14, 122) for gas exchange between the interior chamber (25) and the exterior of the labware device (20). A filter (50) is positioned within the space (72, 120) and is configured to filter contaminants from gas entering the interior chamber (25) via the path.

Abstract: Described are pipettes capable of dispensing both high volumes of liquid and highly accurate smaller volumes of liquid wherein the accuracy of the volume of liquid delivered increases along the length of the pipette. Embodiments of the pipette include an elongated body with an outer surface, an inner surface defining a lumen within the elongated body, a proximal orifice at a proximal end, a distal orifice at a distal end. The intermediate portion includes a first generally frustoconical-shaped portion defined by a first inner diameter proximate the proximal end of the elongated body and a second inner diameter proximate a second end thereof. In an embodiment, the intermediate portion includes a second generally frustoconical-shaped portion defined by a third inner diameter proximate the transition to the first portion and a fourth inner diameter adjacent the distal end of the elongated body.

Abstract: A cell culture device (10) of the cultivation of cells. The cell culture device (10) includes a plurality of trays (12a, 12b, 12c, 12d), each tray (12a, 12b, 12c, 12d) having a cell growth surface (20) and at least one wall (22, 24) extending upwardly from the cell growth surface (20). The at least one wall (22, 24) is configured to receive an additional tray thereon. A ratio of the number of the plurality of trays (12a, 12b, 12c, 12d) per a height dimension of the plurality of trays (12a, 12b, 12c, 12d) is greater than or equal to about 1 tray per 12 mm.

Abstract: A closure (10, 100, 150) for a labware device (20). The labware device (20) defines an interior chamber (25) having at least one opening (92). The closure (10, 100, 150) includes a closure body (12, 102) configured to be mounted to the labware device (20) and in fluid communication with the opening (92). A vent valve (14, 122) is mounted for movement relative to the closure body (12, 102). The vent valve (14, 122), with the closure body (12, 102), defines a space (72, 120) that defines a path between the closure body (12, 102) and the vent valve (14, 122) for gas exchange between the interior chamber (25) and the exterior of the labware device (20). A filter (50) is positioned within the space (72, 120) and is configured to filter contaminants from gas entering the interior chamber (25) via the path.