Patents by Inventor John M. Stewart

John M. Stewart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR THE DETECTION OF TRPV-6 CANCERS AND DRUG DELIVERY
    Publication number: 20220175977
    Abstract: Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
    Type: Application
    Filed: July 15, 2021
    Publication date: June 9, 2022
    Inventor: John M. STEWART
  • Compounds and methods for the detection of TRPV-6 cancers and drug delivery
    Patent number: 11090396
    Abstract: Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: August 17, 2021
    Assignee: Soricimed Biopharma Inc.
    Inventor: John M. Stewart
  • TRPV3 AGONISTS FOR THE TREATMENT OF SKIN CONDITIONS
    Publication number: 20210137811
    Abstract: Described are methods and uses of TRPV3 agonists for the treatment of conditions associated with TRPV3 pathophysiology such as acne, psoriasis, dermatitis, would healing, the inhibition of hair growth, anxiety or depression. Peptides comprising all or part of the C-terminal portion of soricidin are shown to activate TRPV3 cation channel activity and/or promote wound healing in keratinocytes.
    Type: Application
    Filed: December 11, 2020
    Publication date: May 13, 2021
    Inventor: John M. Stewart
  • TRPV3 agonists for the treatment of skin conditions
    Patent number: 10864152
    Abstract: Described are methods and uses of TRPV3 agonists for the treatment of conditions associated with TRPV3 pathophysiology such as acne, psoriasis, dermatitis, would healing, the inhibition of hair growth, anxiety or depression. Peptides comprising all or part of the C-terminal portion of soricidin are shown to activate TRPV3 cation channel activity and/or promote wound healing in keratinocytes.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: December 15, 2020
    Assignee: Soricimed Biopharma Inc.
    Inventor: John M. Stewart
  • TRPV6 INHIBITORS AND COMBINATION THERAPIES FOR TREATING CANCERS
    Publication number: 20200384069
    Abstract: Provided is the use of TRPV6 inhibitor for treating cancer in combination with immune checkpoint modulators, such as PD-1 and PD-L1 inhibitors, and related compositions and kits.
    Type: Application
    Filed: November 30, 2018
    Publication date: December 10, 2020
    Inventor: John M. STEWART
  • COMPOUNDS AND METHODS FOR THE DETECTION OF TRPV-6 CANCERS AND DRUG DELIVERY
    Publication number: 20190209717
    Abstract: Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
    Type: Application
    Filed: July 26, 2018
    Publication date: July 11, 2019
    Inventor: John M. STEWART
  • Compounds and methods for the detection of TRPV-6 cancers and drug delivery
    Patent number: 10064964
    Abstract: Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: September 4, 2018
    Assignee: SORICIMED BIOPHARMA INC.
    Inventor: John M. Stewart
  • Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity
    Patent number: 10058587
    Abstract: The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity. The peptides of the invention are useful for preventing or treating cancer.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: August 28, 2018
    Assignee: Soricimed Biopharma Inc.
    Inventor: John M. Stewart
  • TRPV3 AGONISTS FOR THE TREATMENT OF SKIN CONDITIONS
    Publication number: 20180085296
    Abstract: Described are methods and uses of TRPV3 agonists for the treatment of conditions associated with TRPV3 pathophysiology such as acne, psoriasis, dermatitis, would healing, the inhibition of hair growth, anxiety or depression. Peptides comprising all or part of the C-terminal portion of soricidin are shown to activate TRPV3 cation channel activity and/or promote wound healing in keratinocytes.
    Type: Application
    Filed: September 14, 2017
    Publication date: March 29, 2018
    Inventor: John M. Stewart
  • Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders
    Patent number: 9573983
    Abstract: The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune disorders in a subject. The present disclosure provides compounds including a modified I-domain peptide having two or more modified lysine residues and two or more signal 1 moieities conjugated to the modified lysine residues of the I-domain peptide and methods of using an making the compounds.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: February 21, 2017
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Teruna J. Siahaan, Prakash Manikwar, Paul Kipkemboi Kiptoo, Ahmed Badawi, Barlas Buyuktimkin, John M. Stewart
  • PEPTIDE COMPOSITION FOR CANCER TREATMENT BY INHIBITING TRPV6 CALCIUM CHANNEL ACTIVITY
    Publication number: 20160206694
    Abstract: The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity. The peptides of the invention are useful for preventing or treating cancer.
    Type: Application
    Filed: April 1, 2016
    Publication date: July 21, 2016
    Inventor: John M. Stewart
  • Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity
    Patent number: 9303077
    Abstract: The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity. The peptides of the invention are useful for preventing or treating cancer.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: April 5, 2016
    Assignee: Soricimed Biopharma Inc.
    Inventor: John M. Stewart
  • VECTORS ENCODING A PARALYTIC PEPTIDE
    Publication number: 20150191519
    Abstract: The invention relates to a low molecular weight peptide isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
    Type: Application
    Filed: February 23, 2015
    Publication date: July 9, 2015
    Inventors: John M. Stewart, Bradley J. Steeves, Karl Vernes
  • COMPOUNDS AND METHODS FOR THE DETECTION OF TRPV-6 CANCERS AND DRUG DELIVERY
    Publication number: 20150182644
    Abstract: Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
    Type: Application
    Filed: December 22, 2014
    Publication date: July 2, 2015
    Inventor: John M. Stewart
  • Vectors encoding a paralytic peptide
    Patent number: 8962817
    Abstract: The invention relates to recombinant expression vectors encoding a low molecular weight peptide isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: February 24, 2015
    Assignee: Soricimed Biopharma Inc.
    Inventors: John M Stewart, Bradley J Steeves, Karl Vernes
  • Method Of Producing A Paralytic Peptide
    Publication number: 20140273204
    Abstract: The invention relates to recombinant expression vectors encoding a low molecular weight peptide isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: John M. Stewart, Bradley J. Steeves, Karl Vernes
  • PEPTIDE COMPOSITION FOR CANCER TREATMENT BY INHIBITING TRPV6 CALCIUM CHANNEL ACTIVITY
    Publication number: 20140187493
    Abstract: The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity. The peptides of the invention are useful for preventing or treating cancer.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Applicant: SORICIMED BIOPHARMA INC.
    Inventor: John M. Stewart
  • Method for treating wrinkles using a paralytic peptide from the shrew
    Patent number: 8673858
    Abstract: The invention relates to a low molecular weight peptide (or suite of related peptides) isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 18, 2014
    Assignee: Soricimed Biopharma Inc.
    Inventors: John M. Stewart, Bradley J. Steeves, Karl Vernes
  • Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity
    Patent number: 8618058
    Abstract: The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity. The peptides of the invention are useful for preventing or treating cancer.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: December 31, 2013
    Assignee: Soricimed Biopharma Inc.
    Inventor: John M. Stewart
  • Method of producing a paralytic peptide
    Patent number: 8338136
    Abstract: The invention relates to a low molecular weight peptide (or suite of related peptides) isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: December 25, 2012
    Assignee: Soricimed Biopharma Inc.
    Inventors: John M. Stewart, Bradley J. Steeves, Karl Vernes