Patents by Inventor John M. Tarbell

John M. Tarbell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR MITIGATING METASTASIS
    Publication number: 20190144867
    Abstract: A method for inhibiting metastasis of cancer cells is provided. Inhibitors of heparan sulfate (HS) or hyaluronic acid (HA) are applied to a tumor or a surgical location after removal of the bulk of the tumor. The inhibitors enzymatically cleave surface HS or HA; genetically modify cancer cells to decrease HS or HA production or interfere with the signaling pathway between HS or HA and a MMP or syndecan.
    Type: Application
    Filed: September 19, 2016
    Publication date: May 16, 2019
    Applicants: Research Foundation of the City University of New York, Memorial Sloan Kettering Cancer Center, The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventors: John M. TARBELL, Lance L. MUNN, Henry QAZI, Zhongdong SHI
  • System and method to simulate hemodynamics
    Patent number: 8318414
    Abstract: A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: November 27, 2012
    Assignee: ICE Development Technologies, LLC
    Inventors: Michael B. Dancu, John M. Tarbell
  • System and method to simulate hemodynamics
    Patent number: 7063942
    Abstract: A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: June 20, 2006
    Inventors: Michael B. Dancu, John M. Tarbell
  • System and method to simulate hemodynamics
    Publication number: 20020042701
    Abstract: A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
    Type: Application
    Filed: October 9, 2001
    Publication date: April 11, 2002
    Inventors: Michael B. Dancu, John M. Tarbell