Abstract: Systems, methods, and devices for treating vascular defects are disclosed herein. In some embodiments, a device for treating an aneurysm includes a plurality of braided filaments configured to be implanted in an aneurysm cavity.

Abstract: Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel.

Abstract: Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive to occlude a hole in a wall of an organ or tissue. Provided are devices prepared from extracellular matrix-derived cell-growth scaffolding to repair defects in walls of organs or tissues. Also provided are methods for preparing the device as well as for using the device.