Patents by Inventor John M. Weiler

John M. Weiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligosaccharide heparin fragments as inhibitors of complement cascade
    Patent number: 4916219
    Abstract: There is disclosed oligosaccharide compounds having heparin-like anticomplement activity and reduced anticoagulant activity as compared with heparin on a weight or molar basis. The oligosaccharide compounds have at least 5 and no greater than 25 saccharide units. The oligosaccharides can have an even nuber of saccharide units with a terminus nonreducing sugar, or an odd number of saccharide units without a terminus nonreducing sugar. There is also disclosed anticomplement pharmaceutical compositions with reduced anticoagulant side effect activity and a process for preparing the oligosaccharide compounds.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: April 10, 1990
    Assignee: University of Iowa Research Foundation
    Inventors: Robert J. Linhardt, John M. Weiler
  • Low molecular weight heparin fragments as inhibitors of complement activation
    Patent number: 4847338
    Abstract: There is disclosed a tetrasaccharide, a hexasaccharide, on octasaccharide and a decasaccharide all capable of inhibiting complement activation and having less tha 33% of undigested native heparin's anticoagulation activity.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: July 11, 1989
    Assignee: University of Iowa Research Foundation
    Inventors: Robert J. Linhardt, Zohar M. Merchant, John M. Weiler, Murali Sharath