Abstract: A tuned mass damper (TMD) system in combination with a floating offshore wind turbine (FOWT) platform includes a barge type FOWT platform having a hull configured to have a wind turbine tower mounted thereon. A TMD system is mounted in the hull and has a first TMD configured to operate at a first frequency, and a second TMD configured to operate at a second frequency different than the first frequency.

Abstract: An apparatus includes a finite impulse response demodulator. The finite impulse response demodulator includes least one stage. Each stage includes a cascaded pair of interferometers. The cascaded pair of interferometers includes a first interferometer and a second interferometer. Optionally, the first interferometer includes a first delay. The second interferometer includes a second delay. The first delay and the second delay are fixed or variable. Optionally, the first delay is unequal or equal to said second delay. Optionally, the first interferometer includes first internal power monitors, and the second interferometer includes second internal power monitors. The first power monitors monitor phase bias conditions within the first interferometer. The second power monitors monitor phase bias conditions within the second interferometer. Optionally, the first interferometer includes a first adjustable coupler, and the second interferometer comprises a second adjustable coupler.

Abstract: The present invention relates generally to compositions and methods of use that include compounds that treat and prevent neurological disorders including Alzheimer's disease, neuroinflammation, and diseases and conditions associated with protein misfolding and/or protein aggregation.

Abstract: The present invention relates generally to compositions and methods of use that include compounds that treat and prevent rheumatoid arthritis, inflammation, and diseases caused by or having inflammation as a symptom.

Abstract: The present invention relates generally to compositions and methods of use that include compounds that treat and prevent viral infections.

Abstract: Elongated mounting strips are provided with a series of evenly spaced apart tile fasteners. The tile fasteners pivot from a storage or shipping position to an installation position where they engage and secure the top edges of cladding tile. Strips of weather resistant material are also mounted to the mounting strips at evenly spaced intervals. The weather resistant strips also pivot from a storage or shipping position to an installation position underlying a joint between a pair of adjacent cladding tiles.

Abstract: Elongated mounting strips are provided with a series of evenly spaced apart tile fasteners. The tile fasteners pivot from a storage or shipping position to an installation position where they engage and secure the top edges of cladding tile. Strips of weather resistant material are also mounted to the mounting strips at evenly spaced intervals. The weather resistant strips also pivot from a storage or shipping position to an installation position underlying a joint between a pair of adjacent cladding tiles.

Abstract: A slate and tile roofing system includes a base layer of compliant roofing material and a series of tile fasteners fixed along a top portion of the roofing material. A series of weather barrier strips is attached to the series of fasteners and fixed to the roofing material. A series of slate tiles is semi-permanently mounted over the weather barriers to form a prefabricated tile roofing subassembly. The subassembly expedites and facilitates the installation of slate and tile roofs without the need for highly specialized labor.

Abstract: A slate and tile roofing system includes a base layer of compliant roofing material and a series of tile fasteners fixed along a top portion of the roofing material. A series of weather barrier strips is attached to the series of fasteners and fixed to the roofing material. A series of slate tiles is semi-permanently mounted over the weather barriers to form a prefabricated tile roofing subassembly. The subassembly expedites and facilitates the installation of slate and tile roofs without the need for highly specialized labor.

Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.

Abstract: A cantilevered leaf spring is biased against the upper edge of a roofing tile to prevent the tile from sliding upward beneath an overlying upper row of roofing tiles. The leaf spring can be formed as a part of a tile fastener which includes a hooked portion for receiving and holding the lower edge of a roofing tile on a roof. A series of tile fasteners is mounted to a layer of roofing material to facilitate installation of tiles without the need for installation tools. Damaged tiles can be easily replaced without the need for installation or removal tools. With this system, each row of underlying tiles is locked in place by the combined effect of an overlying and overlapping row of tiles and a spring awl on an upper fastener pushing the upper edge of a tile downwardly so that the lower edge of the tile is forced into the mouth of a lower fastener.

Abstract: A method and system for managing an aircraft's flight path by identifying and categorizing potential threats in the aircraft's original flight path and determining an alternate flight path. The alternate flight path is selected from potential flight paths and has a threat value lower than any of the potential flight paths. The potential flight path candidates are generated from combinations of the original flight path coordinates, and coordinates that vary from the original coordinates by a set range.

Abstract: Lightweight tile roofs using a single overlap of tiles between adjacent tile courses are protected from wind, rain, snow, ice, humidity and sun with a base layer of water resistant weatherproofing material and with a series of waterproof or water resistant shield strips. The shield strips are laterally spaced apart so as to underlie the cracks, joints or channels formed between the adjacent side edges of each pair of juxtaposed tiles. This double layer of weatherproofing material extends the useful life of lightweight tile roofs.

Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.

Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.

Abstract: A roofing tile installation system includes spaced rows of installation strips each having an elongated base to which is attached a plurality of spaced apart hooks. The hooks are formed with a profile that engages and presses on underlying tiles and that grips and hooks around the lower edge of an overlying tile. Each tile is positioned and held laterally between a pair of hooks and held vertically on the slope of a roof by a single hook. An improved weatherproofing system includes a second layer of water resistive material which protects an underlying layer of plastic weatherproofing material against exposure to sunlight and erosion from wind and rain.

Abstract: An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.

Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.

Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.

Abstract: An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.