Patents by Inventor John M. Yanni

John M. Yanni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6440964
    Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections and ophthalmic infections attributable to one or both of two newly identified Microbacterium species, Microbacterium otitidis and Microbacterium alconae.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: August 27, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, Celeste H. McLean, Linda L. Clark, John M. Yanni
  • Patent number: 6429227
    Abstract: HETE salts, the preparation of HETE salts, the preparation of stable and efficacious HETE compositions, HETE compositions and methods of use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: August 6, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: L. Wayne Schneider, Raymond E. Conrow, Daniel A. Gamache, Terri Pasquine, John M. Yanni, Haresh G. Bhagat
  • Patent number: 6420399
    Abstract: Topical ophthalmic anti-allergy drugs are identified by the extent of their interaction with a phospholipid model membrane. Disclosed are topically administrable ophthalmic formulations containing amphipathic anti-allergy compounds at concentrations such that the drugs have Surface Activity Ratings from about 2-11.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: July 16, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Gustav Graff, John M. Yanni
  • Publication number: 20020077358
    Abstract: The use of HETE derivatives to treat dry eye conditions associated with refractive surgery is disclosed.
    Type: Application
    Filed: September 27, 2001
    Publication date: June 20, 2002
    Applicant: Alcon Universal Ltd.
    Inventors: John M. Yanni, Daniel A. Gamache, Steven T. Miller
  • Patent number: 6395746
    Abstract: Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new class of antibiotics (e.g. trovafloxacin). The compositions also contain one or more anti-inflammatory agents (e.g. dexamethasone). The compositions are utilized to treat ophthalmic, otic, and nasal conditions by topically applying the compositions to the affected tissues.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: May 28, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, John M. Yanni
  • Publication number: 20020049255
    Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.
    Type: Application
    Filed: August 13, 2001
    Publication date: April 25, 2002
    Applicant: Alcon Universal Ltd.
    Inventors: Daniel A. Gamache, Gustav Graff, John M. Yanni, Michael A. Kapin
  • Patent number: 6375973
    Abstract: Topically administrable anti-allergy compositions comprising olopatadine and a polymeric quaternary ammonium preservative are suitable for use by patients wearing contact lenses.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: April 23, 2002
    Assignee: Alcon Universal Ltd.
    Inventor: John M. Yanni
  • Publication number: 20020037929
    Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat angiogenesis-related disorders, including ophthalmic angiogenesis-related disorders such as diabetic retinopathy and exudative macular degeneration, is disclosed.
    Type: Application
    Filed: August 13, 2001
    Publication date: March 28, 2002
    Applicant: Alcon Universal Ltd.
    Inventors: Michael A. Kapin, David P. Bingaman, Daniel A. Gamache, Gustav Graff, John M. Yanni
  • Publication number: 20020028816
    Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections and ophthalmic infections attributable to one or both of two newly identified Microbacterium species, Microbacterium otitidis and Microbacterium alconae.
    Type: Application
    Filed: June 22, 2001
    Publication date: March 7, 2002
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, Celeste H. McLean, Linda L. Clark, John M. Yanni
  • Patent number: 6353022
    Abstract: Compositions containing one or more HETE derivative(s) and an effective concentration of ethanol and methods of use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: March 5, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: L. Wayne Schneider, Daniel A. Gamache, Lori K. Weimer, Timothy L. Kessler, Zhongyou Wei, Terri Pasquine, John M. Yanni, Haresh G. Bhagat
  • Patent number: 6353012
    Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: March 5, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Mark R. Hellberg, John M. Yanni, Gustav Graff, Daniel A. Gamache, Peter G. Klimko
  • Publication number: 20020022629
    Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections and ophthalmic infections attributable to one or both of two newly identified Microbacterium species, Microbacterium otitidis and Microbacterium alconae.
    Type: Application
    Filed: June 22, 2001
    Publication date: February 21, 2002
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, Celeste H. McLean, Linda L. Clark, John M. Yanni
  • Publication number: 20010056093
    Abstract: Topically administrable anti-allergy compositions comprising olopatadine and a polymeric quaternary ammonium preservative are suitable for use by patients wearing contact lenses.
    Type: Application
    Filed: January 24, 2001
    Publication date: December 27, 2001
    Applicant: Alcon Universal, Ltd.
    Inventor: John M. Yanni
  • Patent number: 6274160
    Abstract: A topical ophthalmic composition for the treatment of dry eye in humans, comprising one or more histamine H2 agonists, is disclosed.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: August 14, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Steven T. Miller, Daniel A. Gamache, John M. Yanni
  • Patent number: 6242480
    Abstract: Compounds having ant-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical composition are disclosed.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: June 5, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: John M. Yanni, Gustav Graff
  • Patent number: 6225332
    Abstract: Compositions containing histamine H2 agonists and methods of use for treating allergy and inflammation of the eye are disclosed.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 1, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Steven T. Miller, Daniel A. Gamache, John M. Yanni
  • Patent number: 6225327
    Abstract: Composition and methods for treating ocular allergic reactions are disclosed. In particular, the invention is directed to compounds which inhibit human conjunctival mast cell degranulation.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: May 1, 2001
    Assignees: Alcon Laboratories, Inc., Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Steven T. Miller, Mark R. Hellberg, John M. Yanni
  • Patent number: 6174878
    Abstract: Compositions and methods for treating otic pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists locally for the prevention or alleviation of otic pain.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Patent number: 6174914
    Abstract: Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache, Lori K. Weimer
  • Patent number: 6066671
    Abstract: Compositions of 3-benzoylphenylacetic acid derivatives for treating GLC1A glaucoma and methods for their use are disclosed.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: May 23, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: John M. Yanni, Mark R. Hellberg