Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure provides methods of treating cancer comprising administering a selective dipeptidyl peptidase inhibitor and an OX40 agonist with or without one or more immune checkpoint inhibitors to a subject with cancer. The present disclosure provides pharmaceutical compositions for treating cancer comprising a selective dipeptidyl peptidase inhibitor and an OX40 agonist with or without one or more immune checkpoint inhibitors.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: Provided herein are combination methods and compositions for cancer therapies. The combinations modify multiple arms of the immune system, including an innate immunity modifier, an immune checkpoint inhibitor and a T-cell stimulator, to treat cancer.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: Cartridges and cartridge cases adapted to be chambered in weapon systems are provided. In one example, a cartridge case includes a front shell having a case base end portion, a case body portion extending forward from the case base end portion towards a case mouth portion that is configured for holding a projectile. The case base end portion has a first interlocking feature. A reinforcing cap is disposed adjacent to the case base end portion on a side opposite the internal volume. The reinforcing cap has an annular extraction groove, a primer pocket, a flash hole for providing fluid communication between the primer pocket and the internal volume, and a second interlocking feature that engages the first interlocking feature to couple the reinforcing cap to the case base end portion.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: An apparatus for extending HDMI signal transmission. The apparatus comprises a transmit module and a receive module isolating a native HDMI/DVI cable of indeterminate length and are capable of enabling a relatively long native HDMI/DVI cable to comply with the HDMI specification. The modules each have DC blocks, low speed blocks and high speed blocks and interface with HDMI source and sink devices to maintain HDMI compliance.

Abstract: Described herein is an improved sensing system (30) and its method of operation. The system (30) includes a camera (16) for viewing an external scene, the camera comprising one or more detector(s) and has a field of view (40) which overlaps with the path (32) of a pulsed laser (12). The laser path (32) and radiation from the scene viewed (40) share a beamsplitter (36) and a window (38). In order to substantially reduce back-scattered radiation from the laser path (32) affecting operation of the detector(s) of the camera (16), the detector(s) is (are) switched in accordance with the operation of the laser (12) to be “off” or non-receiving when the laser (12) is “on” or firing.

Abstract: A novel baseball or softball bat is disclosed. The bat has a handle of a heavy, strong wood such as hickory, to resist breakage, and a barrel of a lighter wood such as sapele, to facilitate a controlled and comfortable swing. Methods for making the bat are also disclosed. It may be formed of a plurality of wedge-shaped pieces of wood, and the two species of wood may be joined by interleaving these wedges over part of the bat's length. The interleaving may optionally include a tongue and groove joint or a lap joint for increased strength, and some battens may optionally extend the entire length of the bat.

Abstract: Described herein is an improved sensing system (30) and its method of operation. The system (30) includes a camera (16) for viewing an external scene, the camera comprising one or more detector(s) and has a field of view (40) which overlaps with the path (32) of a pulsed laser (12). The laser path (32) and radiation from the scene viewed (40) share a beamsplitter (36) and a window (38). In order to substantially reduce back-scattered radiation from the laser path (32) affecting operation of the detector(s) of the camera (16), the detector(s) is (are) switched in accordance with the operation of the laser (12) to be ‘off’ or non-receiving when the laser (12) is ‘on’ or firing.

Abstract: A jacketed projectile having one-piece steel core provides good performance regarding chamber pressure, barrel wear and accuracy by separating the jacket from a central tapered portion of the core by providing an encircling air gap that facilitates engraving of the jacket during firing.

Abstract: A novel baseball or softball bat is disclosed. The bat has a handle of a heavy, strong wood such as hickory, to resist breakage, and a barrel of a lighter wood such as sapele, to facilitate a controlled and comfortable swing. Methods for making the bat are also disclosed. It may be formed of a plurality of wedge-shaped pieces of wood, and the two species of wood may be joined by interleaving these wedges over part of the bat's length.