Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: Cartridges and cartridge cases adapted to be chambered in weapon systems are provided. In one example, a cartridge case includes a front shell having a case base end portion, a case body portion extending forward from the case base end portion towards a case mouth portion that is configured for holding a projectile. The case base end portion has a first interlocking feature. A reinforcing cap is disposed adjacent to the case base end portion on a side opposite the internal volume. The reinforcing cap has an annular extraction groove, a primer pocket, a flash hole for providing fluid communication between the primer pocket and the internal volume, and a second interlocking feature that engages the first interlocking feature to couple the reinforcing cap to the case base end portion.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

Abstract: Described herein is an improved sensing system (30) and its method of operation. The system (30) includes a camera (16) for viewing an external scene, the camera comprising one or more detector(s) and has a field of view (40) which overlaps with the path (32) of a pulsed laser (12). The laser path (32) and radiation from the scene viewed (40) share a beamsplitter (36) and a window (38). In order to substantially reduce back-scattered radiation from the laser path (32) affecting operation of the detector(s) of the camera (16), the detector(s) is (are) switched in accordance with the operation of the laser (12) to be “off” or non-receiving when the laser (12) is “on” or firing.

Abstract: Described herein is an improved sensing system (30) and its method of operation. The system (30) includes a camera (16) for viewing an external scene, the camera comprising one or more detector(s) and has a field of view (40) which overlaps with the path (32) of a pulsed laser (12). The laser path (32) and radiation from the scene viewed (40) share a beamsplitter (36) and a window (38). In order to substantially reduce back-scattered radiation from the laser path (32) affecting operation of the detector(s) of the camera (16), the detector(s) is (are) switched in accordance with the operation of the laser (12) to be ‘off’ or non-receiving when the laser (12) is ‘on’ or firing.

Abstract: A jacketed projectile having one-piece steel core provides good performance regarding chamber pressure, barrel wear and accuracy by separating the jacket from a central tapered portion of the core by providing an encircling air gap that facilitates engraving of the jacket during firing.

Abstract: Provided are methods for treating non-small cell lung cancer by administering a therapeutically effective amount of a hedgehog inhibitor.

Abstract: The invention is directed to use of hedgehog inhibitors in conjunction with chemotherapy in treating cancers, and preventing relapses thereby.

Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.