Abstract: A method of characterising a DNA sample obtained from a tumour, the method including the steps of: (a) obtaining a tumour copy number profile for the sample, (b) quantifying a set of copy number features of the copy number profile, and (c) determining exposure to one or more signatures of chromosomal instability based on the quantified features. A copy number feature is a metric that characterises a copy number event in a copy number profile. The set of features does not comprise the absolute copy number of segments in the copy number profile. The signatures of chromosomal instability have been obtained by quantifying the set of copy number features in a plurality of tumour samples, and identifying one or more mutational signatures likely to result in the copy number profiles of the plurality of tumour samples. Methods of characterising types of chromosomal instability present in samples, providing a prognosis, identifying a drug target, or identifying a therapy for a subject are also described.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: A server set may provide a document service to various clients in view of considerations such as availability, fault tolerance, flexibility, and performance. Presented herein are document service architectures that involve partitioning the document set into at least two document ranges, and assigning the respective document ranges to an agent that is deployed to at least one assigned server. A request to apply an operation to a selected document may be fulfilled by identifying the document range of the document; identifying a selected server of the server set that hosts the agent to which the range is assigned; and forwarding the request to the selected server. In some variations, servers may retain detailed information about neighboring servers (e.g., according to logical and/or physical proximity) and scant information about distant servers, thereby avoiding both the extensive information exchange of highly informed network architectures and the inefficiency of uninformed routing algorithms.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: A server set may provide a document service to various clients in view of considerations such as availability, fault tolerance, flexibility, and performance. Presented herein are document service architectures that involve partitioning the document set into at least two document ranges, and assigning the respective document ranges to an agent that is deployed to at least one assigned server. A request to apply an operation to a selected document may be fulfilled by identifying the document range of the document; identifying a selected server of the server set that hosts the agent to which the range is assigned; and forwarding the request to the selected server. In some variations, servers may retain detailed information about neighboring servers (e.g., according to logical and/or physical proximity) and scant information about distant servers, thereby avoiding both the extensive information exchange of highly informed network architectures and the inefficiency of uninformed routing algorithms.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: A server set may provide a document service to various clients in view of considerations such as availability, fault tolerance, flexibility, and performance. Presented herein are document service architectures that involve partitioning the document set into at least two document ranges, and assigning the respective document ranges to an agent that is deployed to at least one assigned server. A request to apply an operation to a selected document may be fulfilled by identifying the document range of the document; identifying a selected server of the server set that hosts the agent to which the range is assigned; and forwarding the request to the selected server. In some variations, servers may retain detailed information about neighboring servers (e.g., according to logical and/or physical proximity) and scant information about distant servers, thereby avoiding both the extensive information exchange of highly informed network architectures and the inefficiency of uninformed routing algorithms.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: A server set may provide a document service to one or more clients, and may be configured to do so in view of various considerations such as availability, fault tolerance, flexibility, and performance. Presented herein are document service architectures that involve partitioning the document set into at least two document ranges, and configuring respective servers of the server set to host one or more agents to which are respectively assigned one or more document ranges. A request for an operation involving at least one document may be routed to a server hosting an agent managing the document ranges of the documents involved in the operation. Moreover, respective servers may retain detailed information about neighboring servers (e.g., according to a logical or physical proximity) and scant information about distant servers, thereby avoiding both the extensive information exchange of highly informed network architectures and the inefficiency of uninformed routing algorithms.

Abstract: The described systems and methods are directed at configuring a server based on a selected role. An installation application is configured to install core components in a server where these core components enable the server to perform the basic functions of a network computing device. A role management application is configured to enable a system administrator to select a role for the server and to automatically determine software components associated with the selected role. The role management application is then configured to build the software components and install the components on the server. The role management application is further configured to configure the components for the selected role. The automated installation process performed by the role management application enables a server to be efficiently configured for a particular role without installing other unnecessary components unrelated to the role.

Abstract: A server set may provide a document service to one or more clients, and may be configured to do so in view of various considerations such as availability, fault tolerance, flexibility, and performance. Presented herein are document service architectures that involve partitioning the document set into at least two document ranges, and configuring respective servers of the server set to host one or more agents to which are respectively assigned one or more document ranges. A request for an operation involving at least one document may be routed to a server hosting an agent managing the document ranges of the documents involved in the operation. Moreover, respective servers may retain detailed information about neighboring servers (e.g., according to a logical or physical proximity) and scant information about distant servers, thereby avoiding both the extensive information exchange of highly informed network architectures and the inefficiency of uninformed routing algorithms.

Abstract: The described systems and methods are directed at configuring a server based on a selected role. An installation application is configured to install core components in a server where these core components enable the server to perform the basic functions of a network computing device. A role management application is configured to enable a system administrator to select a role for the server and to automatically determine software components associated with the selected role. The role management application is then configured to build the software components and install the components on the server. The role management application is further configured to configure the components for the selected role. The automated installation process performed by the role management application enables a server to be efficiently configured for a particular role without installing other unnecessary components unrelated to the role.

Abstract: The described systems and methods are directed at configuring a server based on a selected role. An installation application is configured to install core components in a server where these core components enable the server to perform the basic functions of a network computing device. A role management application is configured to enable a system administrator to select a role for the server and to automatically determine software components associated with the selected role. The role management application is then configured to build the software components and install the components on the server. The role management application is further configured to configure the components for the selected role. The automated installation process performed by the role management application enables a server to be efficiently configured for a particular role without installing other unnecessary components unrelated to the role.

Abstract: The described systems and methods are directed at configuring a server based on a selected role. An installation application is configured to install core components in a server where these core components enable the server to perform the basic functions of a network computing device. A role management application is configured to enable a system administrator to select a role for the server and to automatically determine software components associated with the selected role. The role management application is then configured to build the software components and install the components on the server. The role management application is further configured to configure the components for the selected role. The automated installation process performed by the role management application enables a server to be efficiently configured for a particular role without installing other unnecessary components unrelated to the role.

Abstract: The management of applications in a computing environment often involves a significant number of computing operations, such as acquiring the application, deploying data objects in various locations, and configuring the application with respect to the deployed device. Conventional computing environments may provide inadequate support throughout a typical application life cycle, especially for a computing environment distributed across many devices. Instead, the computing environment may be represented in a deployable object hierarchy that may be distributed to various devices. An application management service may therefore be provided to install representations of the application in the object hierarchy, and to support many other aspects of the application life cycle, such as application discovery, sharing, updating, and removal.

Abstract: File system write filters are provided which can selectively permit or prevent data from being written-protected storage media. The write filter utilized volatile cache memory to store data that is requested to be written to storage media by applications programming interface function calls. In one aspect, if the particular data is requested to be written to a file that is a file identified on the file exclusion list, the data can be written to the file in non-volatile storage. Otherwise, the particular data is written to volatile cache memory. In another aspect, the write filters can be utilized on computing devices to create a stateless computing device wherein data is written to volatile cache memory in response to write function calls. Upon rebooting, any data that was saved to the volatile cache memory is discarded and the computing device is restored to its original state.

Abstract: The described systems and methods are directed at configuring a server based on a selected role. An installation application is configured to install core components in a server where these core components enable the server to perform the basic functions of a network computing device. A role management application is configured to enable a system administrator to select a role for the server and to automatically determine software components associated with the selected role. The role management application is then configured to build the software components and install the components on the server. The role management application is further configured to configure the components for the selected role. The automated installation process performed by the role management application enables a server to be efficiently configured for a particular role without installing other unnecessary components unrelated to the role.

Abstract: A liquid crystal display assembly contains a liquid crystal in a chamber formed between two plates and enclosed by a surrounding seal. Polarizer layers are attached to one or both plates, wherein the polarizer layers extend to the edges of the one or both plates. A uniform thickness adhesive layer is applied to the polarizer layers and additional layers are fixed by the adhesive to the assembly as required by the end purpose of the display. Curing of the uniform thickness adhesive layer results in uniform stress throughout the adhesive layer with resulting reduction of display assembly distortion.