Abstract: The invention relates to compounds of formula (I): and related aspects.

Abstract: The invention relates to compounds of formula (I) and related aspects.

Abstract: A method implemented by a data processing system for enabling a system to pipeline or otherwise process data in conformance with specified criteria by providing a graphical user interface for selecting data to be processed, determining metadata of selected data, and, based on the metadata, automatically processing the selected data in conformance with the specified criteria.

Abstract: A method implemented by a data processing system for enabling a system to pipeline or otherwise process data in conformance with specified criteria by providing a graphical user interface for selecting data to be processed, determining metadata of selected data, and, based on the metadata, automatically processing the selected data in conformance with the specified criteria.

Abstract: The invention relates to compounds of formula (I): (I) and related aspects.

Abstract: A method implemented by a data processing system for enabling a system to pipeline or otherwise process data in conformance with specified criteria by providing a graphical user interface for selecting data to be processed, determining metadata of selected data, and, based on the metadata, automatically processing the selected data in conformance with the specified criteria.

Abstract: A method performed by a data processing system for processing data, the method including: intermittently receiving data from one or more data streams, the received data including data records; detecting two or more particular data records in the received data records, where the detected two or more particular data records each include a particular identifier; for that particular identifier, creating a collection of data records; for at least one particular data record included in the collection of data records, searching data records for a historical aggregation of data; and computing combined data; modifying a data record by inserting the combined data into a field of the data record and by inserting data from at least one of the data records in the collection into another field of the data record; based on applying the rules, writing to memory one or more instructions for initiation of one or more actions.

Abstract: The invention relates to compounds of formula (I): and related aspects.

Abstract: The invention relates to compounds of formula (I) and related aspects.

Abstract: Managing queries performed on one or more data sources includes: storing at least a first query in a storage medium; selecting the first query for processing; instructing a query engine to process the first query on a first portion of data in the one or more data sources for a first query interval; receiving result data from the query engine based on processing the first query on the first portion of data; saving a state of the first query in the storage medium after the first query interval; instructing the query engine to process a second query during a second query interval after the first query interval; and instructing the query engine to process the first query on a second portion of data in the one or more data sources during a third query interval after the second query interval.

Abstract: This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Abstract: A method performed by a data processing system for processing data, the method including: intermittently receiving data from one or more data streams, the received data including data records; detecting two or more particular data records in the received data records, where the detected two or more particular data records each include a particular identifier; for that particular identifier, creating a collection of data records; for at least one particular data record included in the collection of data records, searching data records for a historical aggregation of data; and computing combined data; modifying a data record by inserting the combined data into a field of the data record and by inserting data from at least one of the data records in the collection into another field of the data record; based on applying the rules, writing to memory one or more instructions for initiation of one or more actions.

Abstract: The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, Ra, Rb, Rc, Rd, Rg, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Abstract: This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: This invention relates to imidazopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Abstract: The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, Ra, Rb, Rc, Rd, Rg, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Abstract: The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.