Abstract: Disclosed herein are methods and devices for the inactivation of pathogens (e.g., bacteria, viruses, etc.) in ex vivo stored blood products, such as plasma and/or platelets, by means of directing visible light radiation from an illuminating device into blood product storage containers in order to achieve effective pathogen inactivation without the presence of an added photosensitising agent in the blood product. An exemplary apparatus includes a control unit that operates a light source that emits light in the wavelength region of about 380-500 nm which is directed onto blood product storage bags at sufficient intensity to penetrate the bag material and the opaque blood product therein in order to inactivate pathogens in the blood product but at dose levels that cause no significant detrimental effects on the blood product.

Abstract: The invention relates to compounds of formula (I): and related aspects.

Abstract: The invention relates to compounds of formula (I) and related aspects.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis and including holes through which the cleansed fluid passes. The disc includes a first region in which a first array of said holes is provided, and a second region, radially outward of the first region, in which a second array of said holes is provided. Each hole of the second array has a larger cross-sectional area than each hole of the first array.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis, and including holes running from an upstream face to a downstream face through which the cleansed fluid passes. Each hole has a tapered portion which narrows from an upstream end to a downstream end thereof.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis and including holes through which the cleansed fluid passes. When viewed normal to the disc, each hole is elongate and defines a longitudinal axis which runs within the plane of the disc. The longitudinal axis of each hole is curved.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis and including holes through which the cleansed fluid passes. When viewed normal to the disc, each hole is elongate and defines a longitudinal axis which runs within the plane of the disc. The longitudinal axis of each hole is inclined relative to the radial direction of the disc.

Abstract: A dirt separator including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber, and a disc located at the outlet, the disc being arranged to rotate about a rotational axis and including holes through which the cleansed fluid passes. The holes are distributed over at least first and second regions of the disc, the second region being radially outward of the first region. The porosity of the second region is higher than the porosity of the first region.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate in a predetermined direction about a rotational axis, and including holes running from an upstream face to a downstream face through which the cleansed fluid passes. When viewed along the radial direction of the disc, the path of each hole through the thickness of the disc defines a centreline, the centreline being inclined such that it is non-perpendicular to the disc. The centreline of each hole is inclined such that it intersects the upstream face of the disc at a point which is behind, in the direction of rotation of the disc, the point at which the centreline intersects the downstream face of the disc.

Abstract: Managing queries performed on one or more data sources includes: storing at least a first query in a storage medium; selecting the first query for processing; instructing a query engine to process the first query on a first portion of data in the one or more data sources for a first query interval; receiving result data from the query engine based on processing the first query on the first portion of data; saving a state of the first query in the storage medium after the first query interval; instructing the query engine to process a second query during a second query interval after the first query interval; and instructing the query engine to process the first query on a second portion of data in the one or more data sources during a third query interval after the second query interval.

Abstract: A cyclonic separation apparatus includes an outer wall, an inner wall and a cyclonic chamber defined between the outer wall and inner wall. A section of the surfaces of both the outer wall and the inner wall are flattened. The inner wall and the outer wall are also concentrically arranged. During use a fluid moving around the cyclonic chamber flows between a curved passage and a flattened passage of the cyclonic chamber.

Abstract: This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: A method of setting the value of an operational parameter of a well is provided. The method includes providing a measure related to the actual value of the parameter; setting a maximum limit for the measure; setting a minimum limit for the measure; setting a demanded value for the parameter; and automatically overriding the demanded value if it is such that it would result in the measure exceeding the maximum limit or being below the minimum limit to produce an actual value for the parameter with results in the measure not exceeding the maximum limit and not being below the minimum limit.

Abstract: The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Abstract: A cyclonic separation apparatus includes an outer wall, an inner wall and a cyclonic chamber defined between the outer wall and inner wall. A section of the surfaces of both the outer wall and the inner wall are flattened. The inner wall and the outer wall are also concentrically arranged. During use a fluid moving around the cyclonic chamber flows between a curved passage and a flattened passage of the cyclonic chamber.

Abstract: A method performed by a data processing system for processing data, the method including: intermittently receiving data from one or more data streams, the received data including data records; detecting two or more particular data records in the received data records, where the detected two or more particular data records each include a particular identifier; for that particular identifier, creating a collection of data records; for at least one particular data record included in the collection of data records, searching data records for a historical aggregation of data; and computing combined data; modifying a data record by inserting the combined data into a field of the data record and by inserting data from at least one of the data records in the collection into another field of the data record; based on applying the rules, writing to memory one or more instructions for initiation of one or more actions.

Abstract: The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, Ra, Rb, Rc, Rd, Rg, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Abstract: This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: This invention relates to imidazopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.