Patents by Inventor John MacMicking

John MacMicking has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mouse deficient in inducible nitric oxide synthase
    Patent number: 5850004
    Abstract: The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES) cells which are singly allelic relative to the deficient iNOS locus, a host cell line or cell clone carrying a congenitally altered iNOS gene, and a method of producing such a transgenic mouse.The iNOS-deficient transgenic mice can be used to evaluate and/or test their susceptibility to infectious or tumorigenic challenge, autoimmunity, septic shock and inflammatory and allergic diseases.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: December 15, 1998
    Assignees: Cornell Research Foundation, Inc., Merck & Co., Inc.
    Inventors: John MacMicking, Carl Nathan, John S. Mudgett