Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end sequences having complementarity and subsequently assembling the overlapping complementary sequences. The nuclease agent (e.g., a gRNA-Cas complex) can create double strand breaks in dsDNA in order to create overlapping end sequences or can create nicks on each strand to produce complementary overhanging end sequences. Assembly using the method described herein can assemble any nucleic acids having overlapping sequences or can use a joiner oligo to assemble sequences without complementary ends.

Abstract: The disclosure relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The disclosure also relates to anti-SARS-CoV-2 antibodies that have been obtained from subjects who became immune to this coronavirus, and to methods of using these anti-SARS-CoV-2 antibodies. Methods for neutralizing SARS-CoV-2 are disclosed, as well treatments for SARS-COV-2 using the anti-SARS-CoV-2 antibodies.

Abstract: A portable communications device captures a plurality of data records from a camera and streams the data records to another, external device after detecting a first trigger event and a second trigger event. The portable communications device may initiate streaming of captured data records following detection of only one high confidence trigger event. Data records streamed to an external communications management system are protected from deliberate, inadvertent, or accidental alteration or deletion, thereby protecting the integrity of captured audio and video data. Data records may be stored in a buffer memory in the device when a communications link to an external device is not available, then streamed from the device after a communications link has been established.

Abstract: A camera and accessories clamping mount that includes an assembly of ball and socket members rotatably and moveably interconnectable having an anterior end and a posterior end, a top connector disposed atop the anterior end and a bottom connector disposed on the posterior end, wherein the bottom connector is releasably attachable to a clamp, said clamp attachable to an extant surface, and an extant camera, or other accessory device having a ¼-20? female thread mount, is releasably attachable to the top connector, whereby said camera or other accessory device is supportable and positionable through a range of positions by means of the assembly of ball and socket members.

Abstract: A camera lens shade assembly includes an elongated member having a first end and a second end. The elongated member includes a plurality of attached ball and socket members and is bendable such that first and second ends are positionable with respect to each other. An attachment member is attached to the first end of the elongated member. The attachment apparatus is removably coupled to an image capturing device. A shade is attached to the second end of the elongated member. The shade is positionable relative to a lens of the image capturing device to inhibit light from a selected light source from directly entering the lens.

Abstract: A system for authenticating data of interest includes a digest locator engine capable to locate a first and a second digest result in a data file, including a set of data; a first digest creator capable to create, using a first digest function, a first digest of the set of data, the first digest function being identical to a digest function used to create the first digest result; a second digest creator capable to create, using a second digest function that is incompatible with the first digest function, a second digest of the set of data, the second digest function being identical to a second digest function used to create the second digest result; and a digest comparator engine, communicatively coupled to the digest locator, first digest creator and the second digest creator, capable to compare the first and second created digests with the first and second located digest results respectively.

Abstract: A system enables encoding of a removable mark into digital data, and decoding of the mark from the digital data. The system comprises an encoder and a decoder. The encoder includes a target area locator for locating in digital data a predetermined pattern of values that represents a flat area, and a marker for modifying values in the flat area to encode a mark into the flat area. The decoder attempts to extract the mark from the digital data. The decoder includes a mark area locator for locating a predetermined pattern of values in digital data, and an unmarker coupled to the mark area locator for examining the values to determine the state of each value and extract an embedded mark from the predetermined pattern of values.

Abstract: Aggregation of product data provided from external sources of product data for presentation on an e-commerce website. A set of product data related to a product that is offered for sale in e-commerce is accessed and subjected to an aggregation process. The set of product data is mapped for aggregation with other sets of product data based on an existing mapping or on an absence of an existing mapping. Access is provided to an aggregated set of product data that includes the set of product data that is mapped for aggregation with other sets of product data, for presentation on an e-commerce website.

Abstract: A system for authenticating data of interest includes a digest locator engine capable to locate a first and a second digest result in a data file, including a set of data; a first digest creator capable to create, using a first digest function, a first digest of the set of data, the first digest function being identical to a digest function used to create the first digest result; a second digest creator capable to create, using a second digest function that is incompatible with the first digest function, a second digest of the set of data, the second digest function being identical to a second digest function used to create the second digest result; and a digest comparator engine, communicatively coupled to the digest locator, first digest creator and the second digest creator, capable to compare the first and second created digests with the first and second located digest results respectively.

Abstract: Aggregation of product data provided from external sources of product data for presentation on an e-commerce website. A set of product data related to a product that is offered for sale in e-commerce is accessed and subjected to an aggregation process. The set of product data is mapped for aggregation with other sets of product data based on an existing mapping or on an absence of an existing mapping. Access is provided to an aggregated set of product data that includes the set of product data that is mapped for aggregation with other sets of product data, for presentation on an e-commerce website.

Abstract: A system for authenticating data of interest includes a digest locator engine capable to locate a first and a second digest result in a data file, including a set of data; a first digest creator capable to create, using a first digest function, a first digest of the set of data, the first digest function being identical to a digest function used to create the first digest result; a second digest creator capable to create, using a second digest function that is incompatible with the first digest function, a second digest of the set of data, the second digest function being identical to a second digest function used to create the second digest result; and a digest comparator engine, communicatively coupled to the digest locator, first digest creator and the second digest creator, capable to compare the first and second created digests with the first and second located digest results respectively.

Abstract: A low-dropout regulator with a single-transistor-control providing improved transient response and stability is disclosed. The single-transistor-control provides a dynamic resistance at the output of the regulator for minimizing undershoot and overshoot, and hence improves transient response. Since the single-control transistor reduces the output resistance of the regulator, the output pole is pushed to a sufficiently high frequency without affecting stability. Therefore, the limited choice of combinations of the output capacitance and its equivalent-series-resistance is substantially relaxed.

Abstract: A system enables encoding of a removable mark into digital data, and decoding of the mark from the digital data. The system comprises an encoder and a decoder. The encoder includes a target area locator for locating in digital data a predetermined pattern of values that represents a flat area, and a marker for modifying values in the flat area to encode a mark into the flat area. The decoder attempts to extract the mark from the digital data. The decoder includes a mark area locator for locating a predetermined pattern of values in digital data, and an unmarker coupled to the mark area locator for examining the values to determine the state of each value and extract an embedded mark from the predetermined pattern of values.

Abstract: A system enables encoding of a removable mark into digital data, and decoding of the mark from the digital data. The system comprises an encoder and a decoder. The encoder includes a target area locator for locating in digital data a predetermined pattern of values that represents a flat area, and a marker for modifying values in the flat area to encode a mark into the flat area. The decoder attempts to extract the mark from the digital data. The decoder includes a mark area locator for locating a predetermined pattern of values in digital data, and an unmarker coupled to the mark area locator for examining the values to determine the state of each value and extract an embedded mark from the predetermined pattern of values.

Abstract: Paroxetine maleate and its preparation and use in the treatment and prevention of inter alia depression.

Abstract: Paroxetine maleate and its preparation and use in the treatment and prevention of inter alia depression.

Abstract: A system for authenticating data of interest includes a digest locator engine capable to locate a first and a second digest result in a data file, the data file including a set of data; a first digest creator capable to create, using a first digest function, a first digest of the set of data, the first digest function being identical to a digest function used to create the first digest result; a second digest creator capable to create, using a second digest function that is incompatible with the first digest function, a second digest of the set of data, the second digest function being identical to a second digest function used to create the second digest result; and a digest comparator engine, communicatively coupled to the digest locator, first digest creator and the second digest creator, capable to compare the first and second created digests with the first and second located digest results respectively.

Abstract: A system enables encoding of a removable mark into digital data, and decoding of the mark from the digital data. The system comprises an encoder and a decoder. The encoder includes a target area locator for locating in the digital data a flat area having a flatness value n, and includes a marker for using the flatness value n to encode a mark into the flat area. The decoder attempts to extract a mark that includes a plateau and a core from digital data. The decoder includes a mark area locator for using a flatness value n to search digital data for a possible plateau, an unmarker coupled to the flat area locator for decoding a possible core upon locating a possible plateau and for using the flatness value n to replace the possible core with possible original data, and an authenticator coupled to the unmarker for examining the possible core for accuracy.

Abstract: A low-dropout regulator with a single-transistor-control providing improved transient response and stability is disclosed. The single-transistor-control provides a dynamic resistance at the output of the regulator for minimizing undershoot and overshoot, and hence improves transient response. Since the single-control transistor reduces the output resistance of the regulator, the output pole is pushed to a sufficiently high frequency without affecting stability. Therefore, the limited choice of combinations of the output capacitance and its equivalent-series-resistance is substantially relaxed.