Patents by Inventor John Mao
John Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240089325Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Inventors: Krishna Nemmani, Zebediah Robert Black, Corey Casmedes, Hoang Dang, Yuncheng Gao, Tyler Hargreaves, John Steven Kirtzic, Zongzhe Li, Einar Longva, Victor Mao, Trac Nguyen, Sivarama Kirshna Panguluri, Dalton Sherer, Edward Yang
-
Publication number: 20230270866Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: ApplicationFiled: April 17, 2023Publication date: August 31, 2023Inventors: Yuhua LI, ChiaTing HUANG, John MAO
-
Publication number: 20230190768Abstract: A combination comprising a tricycle compound and use thereof in the preparation of a medicament for treating HBV. The combination is a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof and any one drug in the following groups a-c: a. a hepatitis B surface antigen inhibitor, b. a reverse transcriptase inhibitor, and c. a hepatitis B surface antigen inhibitor and a reverse transcriptase inhibitor.Type: ApplicationFiled: May 14, 2021Publication date: June 22, 2023Inventors: Wenqiang WU, Dong ZHANG, Zhiqiang MA, Yixin ZHOU, John MAO, Zhigan JIANG, Jing WANG, Haiying HE
-
Patent number: 11628220Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: GrantFiled: April 23, 2021Date of Patent: April 18, 2023Assignee: Foresee Pharmaceuticals Co., Ltd.Inventors: Yuhua Li, Chiating Huang, John Mao
-
Publication number: 20210236643Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: ApplicationFiled: April 23, 2021Publication date: August 5, 2021Inventors: Yuhua LI, ChiaTing HUANG, John MAO
-
Patent number: 11013810Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: GrantFiled: January 10, 2020Date of Patent: May 25, 2021Assignee: Foresee Pharmaceuticals Co., Ltd.Inventors: Yuhua Li, ChiaTing Huang, John Mao
-
Publication number: 20200147226Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: ApplicationFiled: January 10, 2020Publication date: May 14, 2020Inventors: Yuhua LI, ChiaTing HUANG, John MAO
-
Patent number: 10532102Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: GrantFiled: August 18, 2017Date of Patent: January 14, 2020Assignee: Foresee Pharmaceuticals Co., Ltd.Inventors: Yuhua Li, ChiaTing Huang, John Mao
-
Patent number: 10272082Abstract: Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.Type: GrantFiled: July 12, 2012Date of Patent: April 30, 2019Assignee: Cytokinetics, Inc.Inventors: Jesse Cedarbaum, John Mao, Fady Malik, Andrew A. Wolff
-
Publication number: 20190054178Abstract: The present invention provides compositions or formulations comprising the combination of a compound of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione or a salt thereof or hydrate of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein the compositions or formulations increases water solubility and oral bioavailability of 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metalloproteinase-12.Type: ApplicationFiled: August 18, 2017Publication date: February 21, 2019Inventors: Yuhua Li, ChiaTing Huang, John Mao
-
Publication number: 20140243344Abstract: Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.Type: ApplicationFiled: July 12, 2012Publication date: August 28, 2014Inventors: Jesse Cedarbaum, John Mao, Fady Malik, Andrew A. Wolff
-
Publication number: 20080040468Abstract: A method for facilitating remote support of an appliance is disclosed. A controlled client installed in an appliance is connected via a server to the controlling client installed in a remote computer. Upon proper initiation the controlled appliance display is shown on the controlling client. The controlling client is able to see and affect the necessary support at the controlled client.Type: ApplicationFiled: August 14, 2006Publication date: February 14, 2008Inventors: John Mao, Larry Dorie
-
Patent number: 6458816Abstract: The present invention relates to compounds according to the structure: Where R is H or CH3; R2 is phosphate which can be free acid or salt; R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C1-C3 alkyl group; R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; and R5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.Type: GrantFiled: October 15, 2001Date of Patent: October 1, 2002Assignee: Vion Pharmaceuticals, Inc.Inventors: Terrence W. Doyle, Srinivasa Karra, Zujin Li, Xu Lin, John Mao, Qi Qiao, Yang Xu
-
Publication number: 20020119955Abstract: The present invention relates to compounds according to the structure: 1Type: ApplicationFiled: October 15, 2001Publication date: August 29, 2002Inventors: Terrence W. Doyle, Srinivasa Karra, Zujin Li, Xu Lin, John Mao, Qi Qiao, Yang Xu