Abstract: A disk drive holder and interconnection system comprises a case, a drive frame, a release mechanism and electrical coupling device. The case holds a plurality of disk drives. Each disk drive is mounted in the case with a drive frame that has a flush release mechanism and a retaining mechanism. The drive frame has guides that are received by slots on the case as the disk drive and frame slide in and out of the case. The release mechanism is used to force the frame away from the case for removal. The system also includes a plurality of electrical connectors and a bus. A first connector provides external access to the bus. The remaining connectors are mounted to a backplane for mating with connectors on the drive frames, thereby coupling the connectors to disk drives automatically as the drive frame slides into the case. The holder also includes an air filter, a fan, a power supply and a distribution system mounted inside the case.