Abstract: An electronic instrument system is described herein. The electronic instrument system includes a display device including a graphical user interface (GUI) display screen displaying computer-generated images thereon and a controller operably coupled to the display device. The controller includes one or more processors programmed to execute an algorithm to display an animated sequence of computer-generated images on the GUI display screen including the steps of receiving a current parameter value and rendering a parameter display screen on the GUI display screen including a hybrid dynamic non-linear display displaying the current parameter value. The one or more processors render the hybrid dynamic non-linear display including a parameter display tape including a linear scale region displayed between a first non-linear scale region and a second non-linear scale region along a scale axis.

Abstract: Expression vectors for rapid and high-throughput cloning, expression and screening of chimeric antigen receptor (CAR) constructs are provided.

Abstract: Compositions and methods for inhibiting, treating, and/or preventing a B-cell neoplasm are provided.

Abstract: The neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis including the unmutated peptide QYNPIRTTF (SEQ ID NO: 1) discovered on HLA-A*24:02 which is derived from the neuroblastoma dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, peptide-centric chimeric antigen receptors (PC-CARs) were developed via a counter panning strategy using predicted potentially cross-reactive peptides. Informed by computational modeling, PHOX2B peptide¬ centric CARs were demonstrated to also recognize QYNPIRTTF (SEQ ID NO: 1) presented by HLA-A*23:01 and the highly divergent HLA-B*14:02. Potent and specific killing of neuroblastoma cells expressing these HEAs in vitro was shown along with complete tumor regression in mice.

Abstract: The present disclosure is directed to chimeric antigen receptors binding to Glypican 2, nucleic acids encoding the same, and cells expressing the same, and methods of using such cells to treat cancers that express or overexpress the Glypican 2 antigen.

Abstract: An airfoil performance monitor comprising a housing mounted on a low pressure face of an airfoil, and defining pitot and static pressure orifices; an airspeed-dependent sensor that senses airflow impinging on the pitot orifices and generates a digital airflow signal indicative of turbulence of the airflow; and a controller that derives a turbulence intensity ratio by filtering turbulence values calculated from the digital airflow signal.

Abstract: Compositions and methods for inhibiting, treating, and/or preventing a B-cell neoplasm are provided.

Abstract: Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. We performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases), and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing to determine the genetic basis for neuroblastoma. On average, each tumor had 19 somatic alterations in coding genes (range, 3-70). Chromosomal deletions and sequence alterations of chromatin remodeling genes, ARID1A and ARID1B, were identified in 8 of 71 neuroblastomas (11%), and these were associated with early treatment failure and decreased survival. These results highlight dysregulation of chromatin remodeling in pediatric tumorigenesis and provide new approaches for the management of neuroblastoma patients.

Abstract: A navigation procedure display is described. The navigational procedure display includes a dynamic information area, positioned within the flight procedure display, for displaying a current procedure instruction and at least one successive procedure instruction. The navigational procedure display also includes a moving map area, positioned within the procedure display, for displaying a current position indication in at least three dimensions and situational awareness symbols.

Abstract: A monitoring system includes one or more monitoring devices, positioned in sewer manholes, storm drains, etc., and a remote monitoring station that communicates wirelessly therewith. The monitoring device may be an integrated unit, including sensors, a two-way telemetry unit, a power supply, a processor, and supporting hardware, all located in an enclosed, waterproof housing. The monitoring device is placed within a manhole cavity to obtain depth (e.g., water level) measurements, images, and other data, and report the measurements back to the remote monitoring station, which analyzes the data and responds to alert messages when a dangerous water level is detected. An additional sensor may monitor the manhole cover for security purposes. A distributed mesh network of wireless nodes may be used to relay communications from the monitoring devices along alternative paths, through bridge nodes that may connect to a public wireless or cellular network.

Abstract: A method and apparatus is disclosed for displaying a dynamic parameter, the apparatus comprises a display unit receiving a display signal and displaying a scale that changes dynamically and non-linearly in accordance with a selected display algorithm, the display unit further displaying a pointer pointing to said scale in accordance with a reading of said dynamic parameter, thereby emphasizing a range of said reading of said dynamic parameter.

Abstract: A monitoring system includes one or more monitoring devices, positioned in sewer manholes, storm drains, etc., and a remote monitoring station that communicates wirelessly therewith. The monitoring device may be an integrated unit, including sensors, a two-way telemetry unit, a power supply, a processor, and supporting hardware, all located in an enclosed, waterproof housing. The monitoring device is placed within a manhole cavity to obtain depth (e.g., water level) measurements, images, and other data, and report the measurements back to the remote monitoring station, which analyzes the data and responds to alert messages when a dangerous water level is detected. An additional sensor may monitor the manhole cover for security purposes. A distributed mesh network of wireless nodes may be used to relay communications from the monitoring devices along alternative paths, through bridge nodes that may connect to a public wireless or cellular network.

Abstract: A monitoring system includes one or more monitoring devices, positioned in sewer manholes, storm drains, etc., and a remote monitoring station that communicates wirelessly therewith. The monitoring device may be an integrated unit, including sensors, a two-way telemetry unit, a power supply, a processor, and supporting hardware, all located in an enclosed, waterproof housing. The monitoring device is placed within a manhole cavity to obtain depth (e.g., water level) measurements, images, and other data, and report the measurements back to the remote monitoring station, which analyzes the data and responds to alert messages when a dangerous water level is detected. An additional sensor may monitor the manhole cover for security purposes. A distributed mesh network of wireless nodes may be used to relay communications from the monitoring devices along alternative paths, through bridge nodes that may connect to a public wireless or cellular network.

Abstract: A navigation procedure display is described. The navigational procedure display includes a dynamic information area, positioned within the flight procedure display, for displaying a current procedure instruction and at least one successive procedure instruction. The navigational procedure display also includes a moving map area, positioned within the procedure display, for displaying a current position indication in at least three dimensions and situational awareness symbols.

Abstract: A monitoring system includes one or more monitoring devices, positioned in sewer manholes, storm drains, etc., and a remote monitoring station that communicates wirelessly therewith. The monitoring device may be an integrated unit, including sensors, a two-way telemetry unit, a power supply, a processor, and supporting hardware, all located in an enclosed, waterproof housing. The monitoring device is placed within a manhole cavity to obtain depth (e.g., water level) measurements, images, and other data, and report the measurements back to the remote monitoring station, which analyzes the data and responds to alert messages when a dangerous water level is detected. An additional sensor may monitor the manhole cover for security purposes. A distributed mesh network of wireless nodes may be used to relay communications from the monitoring devices along alternative paths, through bridge nodes that may connect to a public wireless or cellular network.

Abstract: A method and apparatus is disclosed for displaying a dynamic parameter, the apparatus comprises a display unit receiving a display signal and displaying a scale that changes dynamically and non-linearly in accordance with a selected display algorithm, the display unit further displaying a pointer pointing to said scale in accordance with a reading of said dynamic parameter, thereby emphasizing a range of said reading of said dynamic parameter.

Abstract: A method and apparatus are disclosed for estimating a position of a target of interest using a plurality of position detection sensors wherein for at least one of the sensors, a corresponding time-variant detection probability profile is combined with the detection status received from the sensor and further wherein each of the corresponding detection probability profiles is combined to generate a global detection probability profile, wherein the combining comprises probabilistically adding a first given probability profile in the case where a first given corresponding indication comprises a target detection and probabilistically subtracting a second given probability profile in the case where a corresponding second given indication comprises a target non-detection and wherein the position of the target is estimated using the highest probability region(s) of the generated global detection probability profile.

Abstract: A method and apparatus is disclosed for displaying a dynamic parameter of an aircraft, the apparatus comprises a display unit receiving a display signal and displaying a scale that changes dynamically and non-linearly in accordance with a selected display algorithm, the display unit further displaying a pointer pointing to said scale in accordance with a reading of said dynamic parameter, thereby emphasizing a range of said reading of said dynamic parameter.