Abstract: A spreader for dispersing particulate material onto a ground surface, the spreader broadly comprising a frame, a hopper, wheels, an impeller shaft, and an impeller. The hopper includes an opening to allow the particulate material to pass therethrough. The wheels are rotatable relative to the frame. The impeller shaft is rotatable relative to the hopper. The impeller is coupled to the impeller shaft and rotatable therewith. The impeller has opposing first and second sides and includes a plate with opposing first and second surfaces, a first set of vanes, and a second set of vanes. The impeller is shiftable between a first configuration in which the first side faces a first direction and the second side faces a second direction and a second configuration in which the first side faces the second direction and the second side faces the first direction.

Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with spatial distribution of laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: Systems and methods are described for executing tenant artificial intelligence pipelines by dynamically selecting service providers based on resource consumption. A server can poll a group of service providers and receive resource information that indicates compute, network, storage, and token requirements to perform an action. When the tenant AI pipeline executes, a pipeline engine can select a service provider to execute the action based on stored resource information. The service providers available in the group can also dynamically change based on terms of service.

Abstract: Sublingual or buccal dosage forms comprise at least one antioxidant compound, such as N-acetyl cysteine (NAC), or a pharmaceutically acceptable salt thereof. The sublingual or buccal dosage forms are administered for treating central nervous system (CNS) disorders, such as traumatic brain injury or stroke.

Abstract: Systems and methods are described for a connected AI agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple parties, such as a sending user of the electronic message and a recipient that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: Sublingual or buccal dosage forms comprise at least one antioxidant compound, such as N-acetyl cysteine (NAC), or a pharmaceutically acceptable salt thereof. The sublingual or buccal dosage forms are administered for treating central nervous system (CNS) disorders, such as traumatic brain injury or stroke.

Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: Systems and methods are described for a messaging agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple users, such as a sending user of the electronic message and a recipient user that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: Systems and methods are described for a connected AI agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple parties, such as a sending user of the electronic message and a recipient that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: Systems and methods are described for a connected AI agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple parties, such as a sending user of the electronic message and a recipient that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: Systems and methods are described for executing customer artificial intelligence pipelines by dynamically selecting service providers based on resource consumption. A server can poll a group of service providers and receive resource information that indicates compute, network, storage, and token requirements to perform an action. When the customer AI pipeline executes, a pipeline engine can select a service provider to execute the action based on stored resource information. The service providers available in the group can also dynamically change based on terms of service.

Abstract: Systems and methods are described for a messaging agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple users, such as a sending user of the electronic message and a recipient user that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: Systems and methods are described for executing tenant artificial intelligence pipelines by dynamically selecting service providers based on resource consumption. A server can poll a group of service providers and receive resource information that indicates compute, network, storage, and token requirements to perform an action. When the tenant AI pipeline executes, a pipeline engine can select a service provider to execute the action based on stored resource information. The service providers available in the group can also dynamically change based on terms of service.

Abstract: Systems and methods are described for a connected AI agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple parties, such as a sending user of the electronic message and a recipient that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: The invention includes a UI that allows addition of functional placeholders to an AI pipeline, and a rules engine that chooses pipeline objects during or before AI pipeline execution. The rules engine can select pipeline objects meeting the same function type and object rules of the functional placeholder. The rules engine also applies customizable security rules and artificial intelligence (AI) model routing to queries. Remedial actions are taken when the rule evaluation exceeds a threshold. The remedial actions include transforming the query by replacing sensitive information with a reversible placeholder. The actual result can be modified by reversing the placeholder and redacting additional sensitive information. The system can notify the user, an administrator, and a supervisor regarding the security evaluation and remedial actions. The evaluations can be logged for auditing purposes.

Abstract: Systems and methods are described for a messaging agent for managed multidimensional search based on an electronic message and management policies. A messaging application at a client device can send a new electronic message, such as an email, to a connector service. An attachment can be ingested and stored in a vector database. Then one or more artificial intelligence (“AI”) agents can be selected for responding to the body of the email, such as a query in the body. The responses can be formatted and sent to multiple users, such as a sending user of the electronic message and a recipient user that was copied or also sent the new electronic message. The AI agents can use different AI models, prompts, and vector databases depending on user permissions. This allows for building up vector databases with relevant content items and answering user questions based on those vector databases.

Abstract: This invention relates to an apparatus for obstructing the open end of vertical corner channel pieces of siding often used in residential building applications. Siding terminates at the corners of buildings into a vertical corner channel piece that is typically open on its top and bottom ends. This opening provides opportunity for small animals to enter and damage the building. This invention comprises an enclosing cap with a bottom surface to obstruct the opening of the vertical corner channel piece and two exterior surfaces along with two interior pinching surfaces that secure the apparatus onto the siding piece. This enclosing cap provides an attractive and inexpensive solution to the problem of small animals entering spaces located underneath siding.