Abstract: A broadcast spreader broadly comprising a frame, a hopper, an impeller, a set of wheels, and an electric hub motor. The hopper is supported by the frame and configured to hold a particulate material. The impeller is rotatably connected below the hopper and is configured to receive the particulate material from the hopper and spread the particulate material over a surface. The wheels are rotatably connected to the frame for traversing the surface. The electric hub motor is at least partially positioned in one of the wheels and configured to drivably engage the one of the wheels to propel the hopper along the surface.

Abstract: The present disclosure generally relates to methods and formulations for treating central nervous system (CNS) disorders. The present disclosure involves intranasal delivery of at least one antioxidant compound, allowing for effective treatment of a central nervous system disorder such as traumatic brain injury or stroke.

Abstract: The present invention provides to compositions and methods useful in the treatment of neurological disorders including, but not limited to, Angelman syndrome, depression, traumatic brain injury, stroke, and Alzheimer's disease. CN2097, a rationally designed cyclic peptidomimetic drug that has been demonstrated to have effectiveness in preclinical models for the treatment of neurological disorders, is rapidly cleared and has a short half-life. The present invention provides a stable analog of CN2097.

Abstract: The invention includes a UI that allows addition of functional placeholders to an AI pipeline, and a rules engine that chooses pipeline objects during or before AI pipeline execution. The rules engine can select pipeline objects meeting the same function type and object rules of the functional placeholder. The rules engine also applies customizable security rules and artificial intelligence (AI) model routing to queries. Remedial actions are taken when the rule evaluation exceeds a threshold. The remedial actions include transforming the query by replacing sensitive information with a reversible placeholder. The actual result can be modified by reversing the placeholder and redacting additional sensitive information. The system can notify the user, an administrator, and a supervisor regarding the security evaluation and remedial actions. The evaluations can be logged for auditing purposes.

Abstract: Methods and systems are provided for generation of lower-frequency tactile energy (e.g., vibration) of a vehicle system based on audio signals. In one example, a method may include acquiring an audio signal from an audio system, generating a motor input command, and applying the motor input command to at least a first traction motor and a second traction motor to create a resultant vibrational force.

Abstract: A hands-free footwear and foot cleaning device which allows the user to clean the bottom or the sole of the footwear as well as the exterior surrounding sides of the footwear. The device can also be used to clean a user's bare foot. The device utilizes a plurality of rollers and a series of water line sprayers that are adapted to spray in a direction to contact one or more of the side portion, bottom portion, or top portion of the sole of a footwear or foot. The sprayers are activated by either a sensor or a pressure devise. The device may also include the option of incorporating additional elements for the purpose of cleaning bare feet rather than just the bottoms of the footwear.

Abstract: A particle spreader broadly comprising a hopper supported by a wheeled chassis, a rate plate, and a rate control gauge. The hopper presents a hopper discharge opening in fluid communication with a hopper chamber to permit flow of particles therefrom. The rate plate controls particle flow out of the hopper chamber and presents a plate discharge opening. The rate plate is shiftable between a closed position and a first open position in which the plate discharge opening is in at least partial registration with the hopper discharge opening. The rate control gauge is configured to engage the rate plate when the rate plate is in the first open position. The rate plate is biased toward the rate control gauge. The rate control gauge is adjustable to engage the rate plate when the rate plate is in a second open position.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: Disclosed are various embodiments for accessing resources when a client device complies with distribution rules. A client device receives distribution rules associated with resources that are accessible at a distribution service. The client device determines whether the client device complies with the distribution rules. The client device transmits an indication of compliance for the distribution to the distribution service. The client device receives the resource from the distribution service.

Abstract: Systems and methods described herein are optimized for cutting sealing elements on packages using optical radiation. Packages can pass through a cutting device that applies the optical radiation to damage, vaporize, or cut the sealing element (e.g., tape) on the package. The systems and methods control several aspects of the cutting process to adjust throughput, improve efficiency, and reduce line stoppages. Systems can include an in-feed conveyor that orients packages and rejects packages that are out of specification, which can lead to issues such as jamming or damage to the equipment. Systems can include a variable-speed cut conveyor controlled by a computing system to dynamically adjust the speed of packages based upon historical cut quality, environmental measurement data, and height data related to a vertical dimension of the package.

Abstract: A hands-free footwear and foot cleaning device which allows the user to clean the bottom or the sole of the footwear as well as the exterior surrounding sides of the footwear. The device can also be used to clean a user's bare foot. The device utilizes a plurality of rollers and a series of water line sprayers that are adapted to spray in a direction to contact one or more of the side portion, bottom portion, or top portion of the sole of a footwear or foot. The sprayers are activated by either a sensor or a pressure devise. The device may also include the option of incorporating additional elements for the purpose of cleaning bare feet rather than just the bottoms of the footwear.

Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: A traction battery assembly according to an exemplary aspect of the present disclosure includes a traction battery, an electric machine, an electrical harness assembly, a protrusion adjacent the electrical harness assembly. The protrusion is configured to move from a first position to a second position in response to a loading event. When the protrusion is in the first position, the electric machine is electrically coupled to the traction battery through the electrical harness assembly. When the protrusion is in the second position, the electric machine is electrically decoupled from the traction battery.

Abstract: Provided herein are compounds and compositions that are reversible agonists of the PDZ3 domain of PSD-95. Methods of their use in treating conditions of neural stress, inflammation, and viability are also provided.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: Techniques are presented for the detection of whether an EV is using a household or other user location for charging. A machine learning model is trained on a training population of user locations using historical usage data and a label for a some of the user locations, typically a small proportion, indicating that an EV charges there, where the labels can, for example, be provided by a utility or derived from the EVs' telematics. The trained model can then be applied to un-labeled user locations' electricity usage data to detect EV charging, both assigning a label and a confidence value to the label. If telematics are available, for user locations at which EV charging is detected, the EV charging can be disaggregated from other electricity usage of the user location.

Abstract: Disclosed are various embodiments for accessing resources when a client device complies with distribution rules. A client device receives distribution rules associated with resources that are accessible at a distribution service. The client device determines whether the client device complies with the distribution rules. The client device transmits an indication of compliance for the distribution to the distribution service. The client device receives the resource from the distribution service.

Abstract: Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) of the Formula I: represented by the following structural formula or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.