Patents by Inventor John Martin Lally
John Martin Lally has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9804295Abstract: The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.Type: GrantFiled: May 2, 2006Date of Patent: October 31, 2017Assignee: Novartis AGInventors: Lynn Cook Winterton, John Martin Lally
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Publication number: 20170307780Abstract: The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.Type: ApplicationFiled: July 11, 2017Publication date: October 26, 2017Inventors: Lynn Cook Winterton, John Martin Lally
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Publication number: 20140112994Abstract: The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO? groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.Type: ApplicationFiled: December 20, 2013Publication date: April 24, 2014Applicant: Novartis AGInventors: Michael F. Rubner, Sung Yun Yang, Yongxing Qiu Qiu, Lynn Cook Winterton, John Martin Lally
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Patent number: 8637071Abstract: The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO? groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.Type: GrantFiled: October 10, 2012Date of Patent: January 28, 2014Assignee: Novartis AGInventors: Michael F. Rubner, Sung Yun Yang, Yongxing Qiu, Lynn Cook Winterton, John Martin Lally
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Publication number: 20130228943Abstract: The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.Type: ApplicationFiled: March 19, 2013Publication date: September 5, 2013Inventors: Yongxing Qiu, John Martin Lally, Manal M. Gabriel, Xinming Qian
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Patent number: 8425926Abstract: The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.Type: GrantFiled: July 14, 2004Date of Patent: April 23, 2013Inventors: Yongxing Qiu, John Martin Lally
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Patent number: 8398903Abstract: The invention is concerned with the problem that with known plastic casting molds, especially those of polypropylene, the lenses produced with these molds have a slippery surface. The invention solves this problem through the use of polymers which are notable for their very low oxygen permeability.Type: GrantFiled: October 15, 2010Date of Patent: March 19, 2013Assignee: Novartis AGInventors: Peter Hagmann, Axel Heinrich, Willi Hoerner, Robert Allen Janssen, John Martin Lally, Robert Earl Szokolay, Bernhard Seiferling
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Patent number: 8309117Abstract: The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO? groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.Type: GrantFiled: December 10, 2003Date of Patent: November 13, 2012Assignee: Novartis, AGInventors: Michael F. Rubner, Sung Yun Yang, Yongxing Qiu, Lynn Cook Winterton, John Martin Lally
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Publication number: 20120276278Abstract: The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Inventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Nicholas Kotov, Manal M. Gabriel, Xinming Qian
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Patent number: 8172395Abstract: The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.Type: GrantFiled: November 25, 2003Date of Patent: May 8, 2012Assignee: Novartis AGInventors: Fiona Patricia Carney, Manal M. Gabriel, Carol Ann Morris, John Martin Lally
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Publication number: 20110057337Abstract: The invention is concerned with the problem that with known plastic casting moulds, especially those of polypropylene, the lenses produced with these moulds have a slippery surface. The invention solves this problem through the use of polymers which are notable for their very low oxygen permeability.Type: ApplicationFiled: October 15, 2010Publication date: March 10, 2011Applicant: NOVARTIS AGInventors: Peter HAGMANN, Axel Heinrich, Willi Hoerner, Robert Allen Janssen, John Martin Lally, Robert Earl Szokolay, Bernhard Seiferling
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Patent number: 7901706Abstract: The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.Type: GrantFiled: October 31, 2007Date of Patent: March 8, 2011Assignee: Novartis AGInventors: John Martin Lally, Nicholas Kotov
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Patent number: 7875660Abstract: Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.Type: GrantFiled: March 17, 2010Date of Patent: January 25, 2011Assignee: Novartis AGInventors: Lynn Cook Winterton, Juergen Vogt, John Martin Lally, Friedrich Stockinger
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Patent number: 7845615Abstract: The invention is concerned with the problem that with known plastic casting moulds, especially those of polypropylene, the lenses produced with these moulds have a slippery surface. The invention solves this problem through the use of polymers which are notable for their very low oxygen permeability.Type: GrantFiled: September 14, 2004Date of Patent: December 7, 2010Assignee: Novartis AGInventors: Peter Hagmann, Axel Heinrich, Willi Hoerner, Robert Allen Janssen, John Martin Lally, Robert Earl Szokolay, Bernhard Seiferling
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Publication number: 20100242409Abstract: Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.Type: ApplicationFiled: March 17, 2010Publication date: September 30, 2010Inventors: Lynn Cook Winterton, Juergen Vogt, John Martin Lally, Friedrich Stockinger
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Patent number: 7798639Abstract: The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.Type: GrantFiled: March 9, 2005Date of Patent: September 21, 2010Assignee: Novartis AGInventors: Lynn Cook Winterton, Yongxing Qiu, John Martin Lally, Manal M. Gabriel
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Patent number: 7705067Abstract: Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.Type: GrantFiled: May 13, 2009Date of Patent: April 27, 2010Assignee: Novartis AGInventors: Lynn Cook Winterton, Juergen Vogt, John Martin Lally, Friedrich Stockinger
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Patent number: 7666461Abstract: The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.Type: GrantFiled: October 20, 2004Date of Patent: February 23, 2010Assignee: Novartis AGInventors: Yongxing Qiu, Fiona Patricia Carney, Nichola Kotov, John Martin Lally, Carol Ann Morris
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Publication number: 20090288369Abstract: Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.Type: ApplicationFiled: May 13, 2009Publication date: November 26, 2009Inventors: Lynn Cook Winterton, Juergen Vogt, John Martin Lally, Friedrich Stockinger
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Patent number: 7582327Abstract: The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.Type: GrantFiled: May 25, 2005Date of Patent: September 1, 2009Assignee: Novartis AGInventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally