Abstract: The invention relates to B-catenin, and to the use of compounds which can affect B-catenin translocation within the cell, for use in treating B-catenin/Wnt-signaling-related disorders, such as osteoporosis, cancer or diabetes. The invention extends to pharmaceutical formulations and compositions comprising such compounds.

Abstract: In at least one embodiment, a purge system for a fuel cell stack is provided. The system comprises a blower, a differential pressure sensor and a purge valve. The blower delivers a recirculated gas back to the stack at varying electrical power levels and blower speeds. The differential pressure sensor senses pressure of the recirculated gas across the blower. The purge valve purges the recirculated gas based on at least one of a blower power level, a blower speed, and the pressure of the recirculated gas.

Abstract: In at least one embodiment, a purge system for a fuel cell stack is provided. The system comprises a blower, a differential pressure sensor and a purge valve. The blower delivers a recirculated gas back to the stack at varying electrical power levels and blower speeds. The differential pressure sensor senses pressure of the recirculated gas across the blower. The purge valve purges the recirculated gas based on at least one of a blower power level, a blower speed, and the pressure of the recirculated gas.

Abstract: The present inventors have identified cancer associated mutations in plexinB1, which is a transmembrane receptor that mediates semaphorin signaling. The frequency of plexinB1 mutations, in particular in prostate and breast cancer, indicates that plexinB1 may be useful in the screening and diagnosis of cancer and as a drug target in the development of anti-cancer therapeutics.

Abstract: In at least one embodiment, a purge system for a fuel cell stack is provided. The system comprises a blower, a differential pressure sensor and a purge valve. The blower delivers a recirculated gas back to the stack at varying electrical power levels and blower speeds. The differential pressure sensor senses pressure of the recirculated gas across the blower. The purge valve purges the recirculated gas based on at least one of a blower power level, a blower speed, and the pressure of the recirculated gas.

Abstract: A baseball batting device includes an elongate lever arm having opposed proximate and distal ends. The device includes a fulcrum lowerly adjacent the lever arm for separating the proximate or distal end of the lever arm from a ground surface during use. The lever arm is rotatable about the fulcrum between a first position in which the distal end is adjacent a ground surface and a second position in which the distal end is separated from the ground surface. A downward force exerted on the proximate end moves the lever arm from the first position to the second position. The lever arm distal end is configured to support a baseball when the lever arm is at the first position and to release the baseball when the lever arm is at the second position. The fulcrum and distal end are adjustable so as to modify the path of a tossed ball.

Abstract: A light control system and method for a film viewer (10). The viewer (10) includes an infrared emitter (50) with an infrared detector (52) in communication with a microprocessor (34). When a radiograph (40) is inserted within the film viewer (10), the radiograph (10) is interposed between the emitter (50) and detector (52). The microprocessor (34) detects a change in the emissions sensed by the detector (52) and illuminates the viewer (10). The invention also provides a film holder (16) that includes a plurality of rollers (60) interposed between the holder (16) and the screen (14).

Abstract: A light control system and method for a film viewer (10). The viewer (10) includes an infrared emitter (50) with an infrared detector (52) in communication with a microprocessor (34). When a radiograph (40) is inserted within the film viewer (10), the radiograph (10) is interposed between the emitter (50) and detector (52). The microprocessor (34) detects a change in the emissions sensed by the detector (52) and illuminates the viewer (10). The invention also provides a film holder (16) that includes a plurality of rollers (60) interposed between the holder (16) and the screen (14).

Abstract: Compounds of the general formula (1) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

Abstract: The present inventors have identified cancer associated mutations in plexinB1, which is a transmembrane receptor that mediates semaphorin signaling. The frequency of plexinB1 mutations, in particular in prostate and breast cancer, indicates that plexinB1 may be useful in the screening and diagnosis of cancer and as a drug target in the development of anti-cancer therapeutics.

Abstract: N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.